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Protein

Serum amyloid P-component

Gene

APCS

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi77Calcium 1PROSITE-ProRule annotation1
Metal bindingi78Calcium 1PROSITE-ProRule annotation1
Metal bindingi155Calcium 1PROSITE-ProRule annotation1
Metal bindingi155Calcium 2PROSITE-ProRule annotation1
Metal bindingi156Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi157Calcium 1PROSITE-ProRule annotation1
Metal bindingi157Calcium 2PROSITE-ProRule annotation1
Metal bindingi167Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid P-component
Short name:
SAP
Gene namesi
Name:APCS
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Secreted

Pathology & Biotechi

Involvement in diseasei

SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002354320 – 224Serum amyloid P-componentAdd BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi55 ↔ 114PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiO19063
PRIDEiO19063

Interactioni

Subunit structurei

Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO19063
SMRiO19063
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 224Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST201

Sequence similaritiesi

Belongs to the pentraxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00760000119128
HOVERGENiHBG005405
InParanoidiO19063

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O19063-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERLLLWVSV LASLPEAFAH RDLTGKVFVF PRESATDHVK LITKLEKPLQ
60 70 80 90 100
NFTLCFRAYS DLSRGYSLFS YNLQGKDNEL LVFKHRIGEY SLYIGKTKVT
110 120 130 140 150
FKVREVFPRP VHICTSWESS TGIAEFWING EPLVKKGLRQ GYSVGAYPRI
160 170 180 190 200
VLGQEQDSYG GGFDKTQSFV GEIGDLYMWG SVLSPNEIRL VYQGLSFPHP
210 220
TILDWQALNY EMNGYVVIKP RVWS
Length:224
Mass (Da):25,641
Last modified:January 1, 1998 - v1
Checksum:i9D1867691EBEDC66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005546 mRNA Translation: BAA21474.1
RefSeqiNP_999052.1, NM_213887.1
UniGeneiSsc.14517

Genome annotation databases

EnsembliENSSSCT00000044230; ENSSSCP00000035458; ENSSSCG00000037268
GeneIDi396921
KEGGissc:396921

Similar proteinsi

Entry informationi

Entry nameiSAMP_PIG
AccessioniPrimary (citable) accession number: O19063
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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