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Protein

Serum amyloid P-component

Gene

APCS

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi77 – 771Calcium 1By similarity
Metal bindingi78 – 781Calcium 1By similarity
Metal bindingi155 – 1551Calcium 1By similarity
Metal bindingi155 – 1551Calcium 2By similarity
Metal bindingi156 – 1561Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi157 – 1571Calcium 1By similarity
Metal bindingi157 – 1571Calcium 2By similarity
Metal bindingi167 – 1671Calcium 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid P-component
Short name:
SAP
Gene namesi
Name:APCS
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Secreted

Pathology & Biotechi

Involvement in diseasei

SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 224205Serum amyloid P-componentPRO_0000023543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence analysis
Disulfide bondi55 ↔ 114By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.

Structurei

3D structure databases

ProteinModelPortaliO19063.
SMRiO19063. Positions 20-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 224205PentaxinAdd
BLAST

Sequence similaritiesi

Belongs to the pentaxin family.Curated
Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005405.
InParanoidiO19063.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O19063-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERLLLWVSV LASLPEAFAH RDLTGKVFVF PRESATDHVK LITKLEKPLQ
60 70 80 90 100
NFTLCFRAYS DLSRGYSLFS YNLQGKDNEL LVFKHRIGEY SLYIGKTKVT
110 120 130 140 150
FKVREVFPRP VHICTSWESS TGIAEFWING EPLVKKGLRQ GYSVGAYPRI
160 170 180 190 200
VLGQEQDSYG GGFDKTQSFV GEIGDLYMWG SVLSPNEIRL VYQGLSFPHP
210 220
TILDWQALNY EMNGYVVIKP RVWS
Length:224
Mass (Da):25,641
Last modified:January 1, 1998 - v1
Checksum:i9D1867691EBEDC66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005546 mRNA. Translation: BAA21474.1.
RefSeqiNP_999052.1. NM_213887.1.
UniGeneiSsc.14517.

Genome annotation databases

GeneIDi396921.
KEGGissc:396921.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005546 mRNA. Translation: BAA21474.1.
RefSeqiNP_999052.1. NM_213887.1.
UniGeneiSsc.14517.

3D structure databases

ProteinModelPortaliO19063.
SMRiO19063. Positions 20-223.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396921.
KEGGissc:396921.

Organism-specific databases

CTDi325.

Phylogenomic databases

HOVERGENiHBG005405.
InParanoidiO19063.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complementary DNA sequence of porcine serum amyloid P component (SAP)."
    Ozawa A., Matsumoto M., Kajikawa M., Hanazono M., Yasue H.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Landrace.
    Tissue: Liver.

Entry informationi

Entry nameiSAMP_PIG
AccessioniPrimary (citable) accession number: O19063
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 1, 1998
Last modified: December 9, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.