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O19023 (CEL3B_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chymotrypsin-like elastase family member 3B
EC=3.4.21.70
Alternative name(s):
Elastase IIIB
Elastase-3B
Protease E
Gene names
Name:CELA3B
Synonyms:ELA3B
OrganismMacaca mulatta (Rhesus macaque)
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length257 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Efficient protease with alanine specificity but only little elastolytic activity By similarity.

Catalytic activity

Preferential cleavage: Ala-|-Xaa. Does not hydrolyze elastin.

Sequence similarities

Belongs to the peptidase S1 family. Elastase subfamily.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide‹1 – 2›2Or 3 Potential
Propeptide3 – 1513Activation peptide Potential
PRO_0000027701
Chain16 – ›257›242Chymotrypsin-like elastase family member 3B
PRO_0000027702

Regions

Domain16 – 255240Peptidase S1

Sites

Active site601Charge relay system By similarity
Active site1101Charge relay system By similarity
Active site2041Charge relay system By similarity

Amino acid modifications

Glycosylation381N-linked (GlcNAc...) Potential
Disulfide bond45 ↔ 61 By similarity
Disulfide bond104 ↔ 107 By similarity
Disulfide bond144 ↔ 210 By similarity
Disulfide bond175 ↔ 191 By similarity
Disulfide bond200 ↔ 231 By similarity

Experimental info

Non-terminal residue11
Non-terminal residue2571

Sequences

Sequence LengthMass (Da)Tools
O19023 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 4D443DB67233D8DC

FASTA25727,687
        10         20         30         40         50         60 
VASGYGPPSS HPSSRVVNGE DAVPYSWPWQ VSLQYEKNGS FHHTCGGSLI APDWVVTAGH 

        70         80         90        100        110        120 
CISSSLTYQV ALGDYNLAVK EGPEQVIPIN SGDLFVHPLW NRLCVACGND IALIKLSRSA 

       130        140        150        160        170        180 
QLGDAVQLAS LPPAGDILPN ETPCYITGWG RLYTNGPLPD KLQRALLPVV DYEHCSKWNW 

       190        200        210        220        230        240 
WGSTVKKTMV CAGGDIRSGC NGDSGGPLNC PTDDGGWQVH GVTSFVSSFG CNTQRKPTVF 

       250 
TRVSAFIDWI EETIASH

« Hide

References

[1]"Pancreatic elastase from rhesus monkey."
Sziegoleit A.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ000067 mRNA. Translation: CAA03899.1.
UniGeneMmu.3417.

3D structure databases

ProteinModelPortalO19023.
SMRO19023. Positions 10-257.
ModBaseSearch...

Protein family/group databases

MEROPSS01.154.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGprNOG05274.
GeneTreeENSGT00550000074117.
InParanoidO19023.
OrthoDBEOG4XPQGN.

Family and domain databases

InterProIPR009003. Pept_cys/ser_Trypsin-like.
IPR018114. Peptidase_S1/S6_AS.
IPR001254. Peptidase_S1_S6.
IPR001314. Peptidase_S1A.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. Pept_Ser_Cys. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCEL3B_MACMU
AccessionPrimary (citable) accession number: O19023
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 1, 1998
Last modified: November 16, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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