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O19015 (BGAL_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-galactosidase

EC=3.2.1.23
Alternative name(s):
Acid beta-galactosidase
Short name=Lactase
Gene names
Name:GLB1
Synonyms:BGAL
OrganismFelis catus (Cat) (Felis silvestris catus) [Reference proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length669 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subcellular location

Lysosome.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Propeptide25 – 295 By similarity
PRO_0000012183
Chain30 – 669640Beta-galactosidase
PRO_0000012184

Sites

Active site1891Proton donor By similarity
Active site2691Nucleophile Potential

Amino acid modifications

Glycosylation271N-linked (GlcNAc...) Potential
Glycosylation2481N-linked (GlcNAc...) Potential
Glycosylation4651N-linked (GlcNAc...) Potential
Glycosylation4991N-linked (GlcNAc...) Potential
Glycosylation5471N-linked (GlcNAc...) Potential
Glycosylation5571N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict4831R → P in AAB86405. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O19015 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 35B84933BB5E2F76

FASTA66975,230
        10         20         30         40         50         60 
MDFPGAARLL SLLLVPLLLG PARGLRNASQ RTFKIDYGHN RFLKDGQPFR YISGSIHYFR 

        70         80         90        100        110        120 
VPRFYWKDRL LKMKMAGLNA IQTYVPWNFH EPQPGQYQFS GEHDVEYFLK LAHELGLLVI 

       130        140        150        160        170        180 
LRPGPYICAE WDMGGLPAWL LLKESIILRS SDPDYLAAVD KWLGVLLPKM KPLLYQNGGP 

       190        200        210        220        230        240 
IITVQVENEY GSYFTCDYDY LRFLQRRFRD HLGGDVLLFT TDGAHEKFLQ CGALQGIYAT 

       250        260        270        280        290        300 
VDFGPDANIT AAFQIQRKSE PRGPLVNSEF YTGWLDHWGQ PHSRVRTEVV ASSLHDVLAH 

       310        320        330        340        350        360 
GANVNLYMFI GGTNFAYWNG ANIPYQPQPT SYDYDAPLSE AGDLTDKYFA LRDVIRKFEK 

       370        380        390        400        410        420 
VPEGFIPPST PKFAYGKVAL QKLKTVEDAL NVLCPAGPIK SLYPLTFIQV KQYFGFVLYR 

       430        440        450        460        470        480 
TTLPQDCSNP TPLSSPLNGV RDRAYVAVDG VPQGVLERSY VITLNITGQA GATLDLLVEN 

       490        500        510        520        530        540 
MGRVNYGRYI NDFKGLISNL TLGSSVLTDW MIFPLDTEDA VRSHLGGWHG RNHGRQDNKA 

       550        560        570        580        590        600 
FAHHSSNYTL PAFYAGNFSI PSGIPDLPQD TFIQFSGWTK GQVWINGFNL GRYWPGRGPQ 

       610        620        630        640        650        660 
VTLFVPRHIL VTSAPNTIMV LELERAPCDD NGPELCTVEF VDRPLISATP TSSHPLPDLS 


DRDSGWDRV 

« Hide

References

[1]"The sequence of feline lysosomal beta-galactosidase."
Varadarajan G.S., Smith B.F., Foureman P., Martin D.R., Varadarajan U., Georgeson M., Baker H.J.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The mutation in feline beta-galactosidase deficiency (GM1 gangliosidosis)."
Smith B.F., Foureman P., Georgeson M., Martin D.R., Baker H.J.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF006749 mRNA. Translation: AAB81350.1.
AF029974 mRNA. Translation: AAB86405.1.
RefSeqNP_001009860.1. NM_001009860.1.

3D structure databases

ProteinModelPortalO19015.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2331052.

Protein family/group databases

CAZyGH35. Glycoside Hydrolase Family 35.

Proteomic databases

PRIDEO19015.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID493927.
KEGGfca:493927.

Organism-specific databases

CTD2720.

Phylogenomic databases

HOVERGENHBG004841.
KOK12309.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProIPR026283. B-gal_1-like.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF13364. BetaGal_dom4_5. 1 hit.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFPIRSF006336. B-gal. 1 hit.
PRINTSPR00742. GLHYDRLASE35.
SUPFAMSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGAL_FELCA
AccessionPrimary (citable) accession number: O19015
Secondary accession number(s): O18898
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: December 11, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries