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O19015

- BGAL_FELCA

UniProt

O19015 - BGAL_FELCA

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Protein
Beta-galactosidase
Gene
GLB1, BGAL
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei189 – 1891Proton donor By similarity
Active sitei269 – 2691Nucleophile Reviewed prediction

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Alternative name(s):
Acid beta-galactosidase
Short name:
Lactase
Gene namesi
Name:GLB1
Synonyms:BGAL
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Propeptidei25 – 295 By similarity
PRO_0000012183
Chaini30 – 669640Beta-galactosidase
PRO_0000012184Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi248 – 2481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi465 – 4651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi499 – 4991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi547 – 5471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi557 – 5571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PRIDEiO19015.

Structurei

3D structure databases

ProteinModelPortaliO19015.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004841.
KOiK12309.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR026283. B-gal_1-like.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF13364. BetaGal_dom4_5. 1 hit.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O19015-1 [UniParc]FASTAAdd to Basket

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MDFPGAARLL SLLLVPLLLG PARGLRNASQ RTFKIDYGHN RFLKDGQPFR    50
YISGSIHYFR VPRFYWKDRL LKMKMAGLNA IQTYVPWNFH EPQPGQYQFS 100
GEHDVEYFLK LAHELGLLVI LRPGPYICAE WDMGGLPAWL LLKESIILRS 150
SDPDYLAAVD KWLGVLLPKM KPLLYQNGGP IITVQVENEY GSYFTCDYDY 200
LRFLQRRFRD HLGGDVLLFT TDGAHEKFLQ CGALQGIYAT VDFGPDANIT 250
AAFQIQRKSE PRGPLVNSEF YTGWLDHWGQ PHSRVRTEVV ASSLHDVLAH 300
GANVNLYMFI GGTNFAYWNG ANIPYQPQPT SYDYDAPLSE AGDLTDKYFA 350
LRDVIRKFEK VPEGFIPPST PKFAYGKVAL QKLKTVEDAL NVLCPAGPIK 400
SLYPLTFIQV KQYFGFVLYR TTLPQDCSNP TPLSSPLNGV RDRAYVAVDG 450
VPQGVLERSY VITLNITGQA GATLDLLVEN MGRVNYGRYI NDFKGLISNL 500
TLGSSVLTDW MIFPLDTEDA VRSHLGGWHG RNHGRQDNKA FAHHSSNYTL 550
PAFYAGNFSI PSGIPDLPQD TFIQFSGWTK GQVWINGFNL GRYWPGRGPQ 600
VTLFVPRHIL VTSAPNTIMV LELERAPCDD NGPELCTVEF VDRPLISATP 650
TSSHPLPDLS DRDSGWDRV 669
Length:669
Mass (Da):75,230
Last modified:January 1, 1998 - v1
Checksum:i35B84933BB5E2F76
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti483 – 4831R → P in AAB86405. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006749 mRNA. Translation: AAB81350.1.
AF029974 mRNA. Translation: AAB86405.1.
RefSeqiNP_001009860.1. NM_001009860.1.

Genome annotation databases

GeneIDi493927.
KEGGifca:493927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006749 mRNA. Translation: AAB81350.1 .
AF029974 mRNA. Translation: AAB86405.1 .
RefSeqi NP_001009860.1. NM_001009860.1.

3D structure databases

ProteinModelPortali O19015.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2331052.

Protein family/group databases

CAZyi GH35. Glycoside Hydrolase Family 35.

Proteomic databases

PRIDEi O19015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 493927.
KEGGi fca:493927.

Organism-specific databases

CTDi 2720.

Phylogenomic databases

HOVERGENi HBG004841.
KOi K12309.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR026283. B-gal_1-like.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF13364. BetaGal_dom4_5. 1 hit.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PIRSFi PIRSF006336. B-gal. 1 hit.
PRINTSi PR00742. GLHYDRLASE35.
SUPFAMi SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEi PS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of feline lysosomal beta-galactosidase."
    Varadarajan G.S., Smith B.F., Foureman P., Martin D.R., Varadarajan U., Georgeson M., Baker H.J.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The mutation in feline beta-galactosidase deficiency (GM1 gangliosidosis)."
    Smith B.F., Foureman P., Georgeson M., Martin D.R., Baker H.J.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiBGAL_FELCA
AccessioniPrimary (citable) accession number: O19015
Secondary accession number(s): O18898
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: December 11, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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