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Protein

Cysteine-rich secretory protein 3

Gene

CRISP3

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • fertilization Source: UniProtKB
  • single organismal cell-cell adhesion Source: UniProtKB
  • spermatogenesis Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich secretory protein 3
Short name:
CRISP-3
Alternative name(s):
Acidic epididymal glycoprotein 2
Short name:
AEG2
Gene namesi
Name:CRISP3
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

  • Secreted By similarity

  • Note: In neutrophils, localized in specific granules.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 245223Cysteine-rich secretory protein 3PRO_0000006267Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi191 ↔ 198PROSITE-ProRule annotation
Disulfide bondi194 ↔ 203PROSITE-ProRule annotation
Disulfide bondi207 ↔ 240PROSITE-ProRule annotation
Disulfide bondi216 ↔ 234PROSITE-ProRule annotation
Disulfide bondi225 ↔ 238PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO19010.

Expressioni

Tissue specificityi

Expressed in the salivary gland, in the ampulla and the seminal vesicle.2 Publications

Interactioni

Subunit structurei

Interacts with A1BG.1 Publication

Protein-protein interaction databases

STRINGi9796.ENSECAP00000005000.

Structurei

3D structure databases

ProteinModelPortaliO19010.
SMRiO19010. Positions 36-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 171130SCPAdd
BLAST
Domaini207 – 24034ShKTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated
Contains 1 ShKT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
HOGENOMiHOG000236338.
HOVERGENiHBG004184.
InParanoidiO19010.
KOiK19919.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O19010-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLPVLLFL AAVLLPFFPA SGQDPGFAAL SITKSEVQKE IVNKHNDLRR
60 70 80 90 100
TVSPLASNML KMQWDSKTAT NAQNWANKCL LQHSKAEDRA VGTMKCGENL
110 120 130 140 150
FMSSIPNSWS DAIQNWHDEV HDFKYGVGPK TPNAVVGHYT QVVWYSSYRV
160 170 180 190 200
GCGIAYCPKQ GTLKYYYVCQ YCPAGNYVNK INTPYEQGTP CARCPGNCDN
210 220 230 240
GLCTNSCEYE DLVSNCDSLK KIAGCEHELL KENCKTTCQC ENKIY
Length:245
Mass (Da):27,308
Last modified:January 1, 1998 - v1
Checksum:i893A4E87F402BA22
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti236 – 2361T → A in CAD31227 (PubMed:12459257).Curated
Sequence conflicti236 – 2361T → A in CAD31228 (PubMed:12459257).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001400 mRNA. Translation: CAA04729.1.
AJ459964 mRNA. Translation: CAD31227.1.
AJ459965 Genomic DNA. Translation: CAD31228.1.
RefSeqiNP_001075343.1. NM_001081874.1.
UniGeneiEca.12456.

Genome annotation databases

GeneIDi100033965.
KEGGiecb:100033965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001400 mRNA. Translation: CAA04729.1.
AJ459964 mRNA. Translation: CAD31227.1.
AJ459965 Genomic DNA. Translation: CAD31228.1.
RefSeqiNP_001075343.1. NM_001081874.1.
UniGeneiEca.12456.

3D structure databases

ProteinModelPortaliO19010.
SMRiO19010. Positions 36-245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000005000.

Proteomic databases

PaxDbiO19010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100033965.
KEGGiecb:100033965.

Organism-specific databases

CTDi10321.

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
HOGENOMiHOG000236338.
HOVERGENiHBG004184.
InParanoidiO19010.
KOiK19919.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRIS3_HORSE
AccessioniPrimary (citable) accession number: O19010
Secondary accession number(s): Q8HXA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.