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Protein

Interleukin-1 receptor antagonist protein

Gene

IL1RN

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor antagonist protein
Short name:
IL-1RN
Short name:
IL-1ra
Short name:
IRAP
Alternative name(s):
IL1 inhibitor
Gene namesi
Name:IL1RN
Synonyms:IL1RA
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525By similarityAdd
BLAST
Chaini26 – 177152Interleukin-1 receptor antagonist proteinPRO_0000015327Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi91 ↔ 141By similarity
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO18999.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000004056.

Structurei

3D structure databases

ProteinModelPortaliO18999.
SMRiO18999. Positions 27-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZQ4. Eukaryota.
ENOG41119SQ. LUCA.
HOGENOMiHOG000231506.
HOVERGENiHBG052099.
InParanoidiO18999.
KOiK05481.
OrthoDBiEOG7X6M1M.
TreeFamiTF300203.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR027166. IL-1RA.
IPR003297. IL-1RA/IL-36.
[Graphical view]
PANTHERiPTHR10078:SF21. PTHR10078:SF21. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01360. INTRLEUKIN1X.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O18999-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIRRRSVRH LISLLLFLFY SETACHPLGK RPCKMQAFRI WDVNQKTFYM
60 70 80 90 100
RNNQLVAGYL QESNTKLQEK IDVVPIEPDA LFLGLHGRKL CLACVKSGDE
110 120 130 140 150
IRFQLEAVNI TDLSKNKEEN KRFTFIRSNS GPTTSFESAA CPGWFLCTAQ
160 170
EADRPVSLTN KPKESFMVTK FYLQEDQ
Length:177
Mass (Da):20,460
Last modified:January 1, 1998 - v1
Checksum:i1ABC377F1F1CF80B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191F → L in AAC39257 (PubMed:9622739).Curated
Sequence conflicti66 – 661Missing in AAD04132 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83714 mRNA. Translation: BAA22529.1.
U92482 mRNA. Translation: AAC39257.1.
AF088186 mRNA. Translation: AAD04132.1.
RefSeqiNP_001075994.1. NM_001082525.2.
UniGeneiEca.13123.
Eca.18515.

Genome annotation databases

GeneIDi100034236.
KEGGiecb:100034236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83714 mRNA. Translation: BAA22529.1.
U92482 mRNA. Translation: AAC39257.1.
AF088186 mRNA. Translation: AAD04132.1.
RefSeqiNP_001075994.1. NM_001082525.2.
UniGeneiEca.13123.
Eca.18515.

3D structure databases

ProteinModelPortaliO18999.
SMRiO18999. Positions 27-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000004056.

Proteomic databases

PaxDbiO18999.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100034236.
KEGGiecb:100034236.

Organism-specific databases

CTDi3557.

Phylogenomic databases

eggNOGiENOG410IZQ4. Eukaryota.
ENOG41119SQ. LUCA.
HOGENOMiHOG000231506.
HOVERGENiHBG052099.
InParanoidiO18999.
KOiK05481.
OrthoDBiEOG7X6M1M.
TreeFamiTF300203.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR027166. IL-1RA.
IPR003297. IL-1RA/IL-36.
[Graphical view]
PANTHERiPTHR10078:SF21. PTHR10078:SF21. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01360. INTRLEUKIN1X.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and functional expression of equine interleukin-1 receptor antagonist."
    Kato H., Ohashi T., Matsushiro H., Watari T., Goitsuka R., Tsujimoto H., Hasegawa A.
    Vet. Immunol. Immunopathol. 56:221-231(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of equine interleukin-1 receptor antagonist and determination of its full-length cDNA sequence."
    Howard R.D., McIlwraith C.W., Trotter G.W., Nyborg J.K.
    Am. J. Vet. Res. 59:712-716(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular characterization of equine interleukin 1 receptor antagonist (IL-1ra) gene."
    Dhar A.K., Thompson M.S., Paradis M.R., Alcivar-Warren A.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-119.

Entry informationi

Entry nameiIL1RA_HORSE
AccessioniPrimary (citable) accession number: O18999
Secondary accession number(s): O77745, Q9TSJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.