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Protein

Cytochrome P450 3A21

Gene

CYP3A21

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi442Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A21 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA21
Cytochrome P450 CM3A-10
Gene namesi
Name:CYP3A21
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518031 – 503Cytochrome P450 3A21Add BLAST503

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000051348

Structurei

3D structure databases

ProteinModelPortaliO18993
SMRiO18993
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140779
HOGENOMiHOG000039127
HOVERGENiHBG108567
InParanoidiO18993
KOiK07424
OMAiMAFEDIQ
OrthoDBiEOG091G0JNC
TreeFamiTF105087

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

O18993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFIPNLAVE TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGTV
60 70 80 90 100
LYYRQGFWKF DMECYKKYGK MWGIYDGRQP VLAITDPNII KTVLVKECYS
110 120 130 140 150
VFTNRRPFGP VGFMKSAISI AQDDEWKRIR SLLSPTFTSG KLKEMVPIIA
160 170 180 190 200
QYGEVLVRNL RREAEKGKPI NMKDIFGAYS MDVITGTSFG VNIDSLNNPQ
210 220 230 240 250
DPFVESTKKL LRFDFLDPFF LSITIFPFLT PILEALNISM FPRDSTSFLR
260 270 280 290 300
KSIKRIKESR LKDTHKHRVD FLQLMIDSQN SKETESDKAL SDLELVAQSI
310 320 330 340 350
IFIFAGYETT SSTLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPATYDTV
360 370 380 390 400
LQMEYLDMVV NETLRLFPLA MRLERVCKKD VEINGVFIPK GVVVMIPSYA
410 420 430 440 450
LHYDPKYWTE PEKFLPERFS KNNKDNIDPY IYTPFGTGPR NCIGMRFALM
460 470 480 490 500
NMKLALIRVL QNFSFKPCKE TQIPLKLRLG GLLQTEKPIV LKVEPRDGTV

SGA
Length:503
Mass (Da):57,564
Last modified:January 1, 1998 - v1
Checksum:i9BFD421D72C76D6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31921 mRNA Translation: BAA22156.1
RefSeqiNP_001191369.1, NM_001204440.1

Genome annotation databases

EnsembliENSCJAT00000058932; ENSCJAP00000051348; ENSCJAG00000035708
GeneIDi100404344
KEGGicjc:100404344

Similar proteinsi

Entry informationi

Entry nameiCP3AL_CALJA
AccessioniPrimary (citable) accession number: O18993
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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