Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O18993

- CP3AL_CALJA

UniProt

O18993 - CP3AL_CALJA

Protein

Cytochrome P450 3A21

Gene

CYP3A21

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. monooxygenase activity Source: UniProtKB

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A21 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA21
    Cytochrome P450 CM3A-10
    Gene namesi
    Name:CYP3A21
    OrganismiCallithrix jacchus (White-tufted-ear marmoset)
    Taxonomic identifieri9483 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
    ProteomesiUP000008225: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Cytochrome P450 3A21PRO_0000051803Add
    BLAST

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Structurei

    3D structure databases

    ProteinModelPortaliO18993.
    SMRiO18993. Positions 30-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00730000110610.
    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.
    OMAiDMECHKK.
    TreeFamiTF105087.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O18993-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFIPNLAVE TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGTV    50
    LYYRQGFWKF DMECYKKYGK MWGIYDGRQP VLAITDPNII KTVLVKECYS 100
    VFTNRRPFGP VGFMKSAISI AQDDEWKRIR SLLSPTFTSG KLKEMVPIIA 150
    QYGEVLVRNL RREAEKGKPI NMKDIFGAYS MDVITGTSFG VNIDSLNNPQ 200
    DPFVESTKKL LRFDFLDPFF LSITIFPFLT PILEALNISM FPRDSTSFLR 250
    KSIKRIKESR LKDTHKHRVD FLQLMIDSQN SKETESDKAL SDLELVAQSI 300
    IFIFAGYETT SSTLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPATYDTV 350
    LQMEYLDMVV NETLRLFPLA MRLERVCKKD VEINGVFIPK GVVVMIPSYA 400
    LHYDPKYWTE PEKFLPERFS KNNKDNIDPY IYTPFGTGPR NCIGMRFALM 450
    NMKLALIRVL QNFSFKPCKE TQIPLKLRLG GLLQTEKPIV LKVEPRDGTV 500
    SGA 503
    Length:503
    Mass (Da):57,564
    Last modified:January 1, 1998 - v1
    Checksum:i9BFD421D72C76D6A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31921 mRNA. Translation: BAA22156.1.
    RefSeqiNP_001191369.1. NM_001204440.1.

    Genome annotation databases

    EnsembliENSCJAT00000058932; ENSCJAP00000051348; ENSCJAG00000035708.
    GeneIDi100404344.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31921 mRNA. Translation: BAA22156.1 .
    RefSeqi NP_001191369.1. NM_001204440.1.

    3D structure databases

    ProteinModelPortali O18993.
    SMRi O18993. Positions 30-496.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCJAT00000058932 ; ENSCJAP00000051348 ; ENSCJAG00000035708 .
    GeneIDi 100404344.

    Organism-specific databases

    CTDi 1576.

    Phylogenomic databases

    GeneTreei ENSGT00730000110610.
    HOGENOMi HOG000039127.
    HOVERGENi HBG108567.
    OMAi DMECHKK.
    TreeFami TF105087.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs."
      Igarashi T., Sakuma T., Isogai M., Nagata R., Kamataki T.
      Arch. Biochem. Biophys. 339:85-91(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP3AL_CALJA
    AccessioniPrimary (citable) accession number: O18993
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3