SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O18993

- CP3AL_CALJA

UniProt

O18993 - CP3AL_CALJA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome P450 3A21
Gene
CYP3A21
Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A21 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA21
Cytochrome P450 CM3A-10
Gene namesi
Name:CYP3A21
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
ProteomesiUP000008225: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytochrome P450 3A21
PRO_0000051803Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliO18993.
SMRiO18993. Positions 30-496.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

GeneTreeiENSGT00730000110610.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
OMAiDMECHKK.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18993-1 [UniParc]FASTAAdd to Basket

« Hide

MDFIPNLAVE TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGTV    50
LYYRQGFWKF DMECYKKYGK MWGIYDGRQP VLAITDPNII KTVLVKECYS 100
VFTNRRPFGP VGFMKSAISI AQDDEWKRIR SLLSPTFTSG KLKEMVPIIA 150
QYGEVLVRNL RREAEKGKPI NMKDIFGAYS MDVITGTSFG VNIDSLNNPQ 200
DPFVESTKKL LRFDFLDPFF LSITIFPFLT PILEALNISM FPRDSTSFLR 250
KSIKRIKESR LKDTHKHRVD FLQLMIDSQN SKETESDKAL SDLELVAQSI 300
IFIFAGYETT SSTLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPATYDTV 350
LQMEYLDMVV NETLRLFPLA MRLERVCKKD VEINGVFIPK GVVVMIPSYA 400
LHYDPKYWTE PEKFLPERFS KNNKDNIDPY IYTPFGTGPR NCIGMRFALM 450
NMKLALIRVL QNFSFKPCKE TQIPLKLRLG GLLQTEKPIV LKVEPRDGTV 500
SGA 503
Length:503
Mass (Da):57,564
Last modified:January 1, 1998 - v1
Checksum:i9BFD421D72C76D6A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31921 mRNA. Translation: BAA22156.1.
RefSeqiNP_001191369.1. NM_001204440.1.

Genome annotation databases

EnsembliENSCJAT00000058932; ENSCJAP00000051348; ENSCJAG00000035708.
GeneIDi100404344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31921 mRNA. Translation: BAA22156.1 .
RefSeqi NP_001191369.1. NM_001204440.1.

3D structure databases

ProteinModelPortali O18993.
SMRi O18993. Positions 30-496.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCJAT00000058932 ; ENSCJAP00000051348 ; ENSCJAG00000035708 .
GeneIDi 100404344.

Organism-specific databases

CTDi 1576.

Phylogenomic databases

GeneTreei ENSGT00730000110610.
HOGENOMi HOG000039127.
HOVERGENi HBG108567.
OMAi DMECHKK.
TreeFami TF105087.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs."
    Igarashi T., Sakuma T., Isogai M., Nagata R., Kamataki T.
    Arch. Biochem. Biophys. 339:85-91(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP3AL_CALJA
AccessioniPrimary (citable) accession number: O18993
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi