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O18993

- CP3AL_CALJA

UniProt

O18993 - CP3AL_CALJA

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Protein

Cytochrome P450 3A21

Gene

CYP3A21

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A21 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA21
Cytochrome P450 CM3A-10
Gene namesi
Name:CYP3A21
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
ProteomesiUP000008225: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytochrome P450 3A21PRO_0000051803Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliO18993.
SMRiO18993. Positions 30-496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiO18993.
OMAiDMECHKK.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18993-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFIPNLAVE TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGTV
60 70 80 90 100
LYYRQGFWKF DMECYKKYGK MWGIYDGRQP VLAITDPNII KTVLVKECYS
110 120 130 140 150
VFTNRRPFGP VGFMKSAISI AQDDEWKRIR SLLSPTFTSG KLKEMVPIIA
160 170 180 190 200
QYGEVLVRNL RREAEKGKPI NMKDIFGAYS MDVITGTSFG VNIDSLNNPQ
210 220 230 240 250
DPFVESTKKL LRFDFLDPFF LSITIFPFLT PILEALNISM FPRDSTSFLR
260 270 280 290 300
KSIKRIKESR LKDTHKHRVD FLQLMIDSQN SKETESDKAL SDLELVAQSI
310 320 330 340 350
IFIFAGYETT SSTLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPATYDTV
360 370 380 390 400
LQMEYLDMVV NETLRLFPLA MRLERVCKKD VEINGVFIPK GVVVMIPSYA
410 420 430 440 450
LHYDPKYWTE PEKFLPERFS KNNKDNIDPY IYTPFGTGPR NCIGMRFALM
460 470 480 490 500
NMKLALIRVL QNFSFKPCKE TQIPLKLRLG GLLQTEKPIV LKVEPRDGTV

SGA
Length:503
Mass (Da):57,564
Last modified:January 1, 1998 - v1
Checksum:i9BFD421D72C76D6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31921 mRNA. Translation: BAA22156.1.
RefSeqiNP_001191369.1. NM_001204440.1.

Genome annotation databases

EnsembliENSCJAT00000058932; ENSCJAP00000051348; ENSCJAG00000035708.
GeneIDi100404344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31921 mRNA. Translation: BAA22156.1 .
RefSeqi NP_001191369.1. NM_001204440.1.

3D structure databases

ProteinModelPortali O18993.
SMRi O18993. Positions 30-496.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCJAT00000058932 ; ENSCJAP00000051348 ; ENSCJAG00000035708 .
GeneIDi 100404344.

Organism-specific databases

CTDi 1576.

Phylogenomic databases

GeneTreei ENSGT00760000118816.
HOGENOMi HOG000039127.
HOVERGENi HBG108567.
InParanoidi O18993.
OMAi DMECHKK.
TreeFami TF105087.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs."
    Igarashi T., Sakuma T., Isogai M., Nagata R., Kamataki T.
    Arch. Biochem. Biophys. 339:85-91(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP3AL_CALJA
AccessioniPrimary (citable) accession number: O18993
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3