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O18993 (CP3AL_CALJA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A21

EC=1.14.14.1
Alternative name(s):
CYPIIIA21
Cytochrome P450 CM3A-10
Gene names
Name:CYP3A21
OrganismCallithrix jacchus (White-tufted-ear marmoset) [Reference proteome]
Taxonomic identifier9483 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Cytochrome P450 3A21
PRO_0000051803

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O18993 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9BFD421D72C76D6A

FASTA50357,564
        10         20         30         40         50         60 
MDFIPNLAVE TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGTV LYYRQGFWKF 

        70         80         90        100        110        120 
DMECYKKYGK MWGIYDGRQP VLAITDPNII KTVLVKECYS VFTNRRPFGP VGFMKSAISI 

       130        140        150        160        170        180 
AQDDEWKRIR SLLSPTFTSG KLKEMVPIIA QYGEVLVRNL RREAEKGKPI NMKDIFGAYS 

       190        200        210        220        230        240 
MDVITGTSFG VNIDSLNNPQ DPFVESTKKL LRFDFLDPFF LSITIFPFLT PILEALNISM 

       250        260        270        280        290        300 
FPRDSTSFLR KSIKRIKESR LKDTHKHRVD FLQLMIDSQN SKETESDKAL SDLELVAQSI 

       310        320        330        340        350        360 
IFIFAGYETT SSTLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPATYDTV LQMEYLDMVV 

       370        380        390        400        410        420 
NETLRLFPLA MRLERVCKKD VEINGVFIPK GVVVMIPSYA LHYDPKYWTE PEKFLPERFS 

       430        440        450        460        470        480 
KNNKDNIDPY IYTPFGTGPR NCIGMRFALM NMKLALIRVL QNFSFKPCKE TQIPLKLRLG 

       490        500 
GLLQTEKPIV LKVEPRDGTV SGA 

« Hide

References

[1]"Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs."
Igarashi T., Sakuma T., Isogai M., Nagata R., Kamataki T.
Arch. Biochem. Biophys. 339:85-91(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D31921 mRNA. Translation: BAA22156.1.
RefSeqNP_001191369.1. NM_001204440.1.

3D structure databases

ProteinModelPortalO18993.
SMRO18993. Positions 30-496.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCJAT00000058932; ENSCJAP00000051348; ENSCJAG00000035708.
GeneID100404344.

Organism-specific databases

CTD1576.

Phylogenomic databases

GeneTreeENSGT00730000110610.
HOGENOMHOG000039127.
HOVERGENHBG108567.
OMADMECHKK.
TreeFamTF105087.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP3AL_CALJA
AccessionPrimary (citable) accession number: O18993
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families