ID   CP2DJ_CALJA             Reviewed;         497 AA.
AC   O18992;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   27-MAR-2024, entry version 119.
DE   RecName: Full=Cytochrome P450 2D19;
DE            EC=1.14.14.1;
DE   AltName: Full=CYPIID19;
DE   AltName: Full=Cytochrome P450 CM2D-1;
GN   Name=CYP2D19;
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=9056237; DOI=10.1006/abbi.1996.9852;
RA   Igarashi T., Sakuma T., Isogai M., Nagata R., Kamataki T.;
RT   "Marmoset liver cytochrome P450s: study for expression and molecular
RT   cloning of their cDNAs.";
RL   Arch. Biochem. Biophys. 339:85-91(1997).
CC   -!- FUNCTION: Responsible for the metabolism of many drugs and
CC       environmental chemicals that it oxidizes.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein
CC         reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
CC         reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC         COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC         ChEBI:CHEBI:142491; EC=1.14.14.1;
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
CC       membrane protein. Microsome membrane; Peripheral membrane protein.
CC   -!- INDUCTION: P450 can be induced to high levels in liver and other
CC       tissues by various foreign compounds, including drugs, pesticides, and
CC       carcinogens.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; D29822; BAA22155.1; -; mRNA.
DR   RefSeq; NP_001191367.1; NM_001204438.1.
DR   AlphaFoldDB; O18992; -.
DR   SMR; O18992; -.
DR   STRING; 9483.ENSCJAP00000004200; -.
DR   Ensembl; ENSCJAT00000004428.5; ENSCJAP00000004200.3; ENSCJAG00000002321.6.
DR   GeneID; 100385343; -.
DR   KEGG; cjc:100385343; -.
DR   CTD; 100385343; -.
DR   eggNOG; KOG0156; Eukaryota.
DR   GeneTree; ENSGT00940000153331; -.
DR   HOGENOM; CLU_001570_22_0_1; -.
DR   InParanoid; O18992; -.
DR   OMA; RYGHVWK; -.
DR   OrthoDB; 2900138at2759; -.
DR   Proteomes; UP000008225; Chromosome 1.
DR   Bgee; ENSCJAG00000002321; Expressed in liver and 4 other cell types or tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   CDD; cd20663; CYP2D; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR008069; Cyt_P450_E_grp-I_CYP2D-like.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   PANTHER; PTHR24300:SF1; CYTOCHROME P450 2D6-RELATED; 1.
DR   PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR01686; EP450ICYP2D.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase; Reference proteome.
FT   CHAIN           1..497
FT                   /note="Cytochrome P450 2D19"
FT                   /id="PRO_0000051743"
FT   BINDING         443
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   497 AA;  55912 MW;  A482AEE71E4D6CAF CRC64;
     MGLDALVPLA VTVAIFVLLV DLMHRRQRWA ARYPPGPMPL PGLGNLLHVD FQNTPNSFNQ
     LRRRFGDVFS LQLAWTPVVV LNGLEAVREA LVTRGEDTAD RPPVPITEML GFGPHSQGLF
     LARYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEATYL CAAFADHAGR PFRPNGLLDK
     AVSNVIASLT CRRRFEYNDP CLLRLLDLTM EGLKEESGLL REVLNAIPVL LRIPGLAGKV
     LRSQKAFLAQ LDELLTEHRM TWDPAQPPRD LTEAFLAEME KTKGNPESSF NDENLHLVVA
     DLFSAGMVTT SITLAWGLLL MILHPDVQRR VQQEIDDVIG RVRRPEMGDQ TYMPYTTAVI
     HEVQRFADIV PLGVTHMTSR DIEVQGFLIP KGTTLFTNLS SVLKDEANWE KPFRFHPEHF
     LDAQGRFVKP EAFLPFSAGR RACLGEPLAR MELFLFFTCL LQRFSFSVPA GQPRPSPHGV
     FAFLVTPSPY ELCAVPR
//