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O18992

- CP2DJ_CALJA

UniProt

O18992 - CP2DJ_CALJA

Protein

Cytochrome P450 2D19

Gene

CYP2D19

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi443 – 4431Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2D19 (EC:1.14.14.1)
    Alternative name(s):
    CYPIID19
    Cytochrome P450 CM2D-1
    Gene namesi
    Name:CYP2D19
    OrganismiCallithrix jacchus (White-tufted-ear marmoset)
    Taxonomic identifieri9483 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
    ProteomesiUP000008225: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Cytochrome P450 2D19PRO_0000051743Add
    BLAST

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Structurei

    3D structure databases

    ProteinModelPortaliO18992.
    SMRiO18992. Positions 34-497.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O18992-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLDALVPLA VTVAIFVLLV DLMHRRQRWA ARYPPGPMPL PGLGNLLHVD    50
    FQNTPNSFNQ LRRRFGDVFS LQLAWTPVVV LNGLEAVREA LVTRGEDTAD 100
    RPPVPITEML GFGPHSQGLF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE 150
    QWVTEEATYL CAAFADHAGR PFRPNGLLDK AVSNVIASLT CRRRFEYNDP 200
    CLLRLLDLTM EGLKEESGLL REVLNAIPVL LRIPGLAGKV LRSQKAFLAQ 250
    LDELLTEHRM TWDPAQPPRD LTEAFLAEME KTKGNPESSF NDENLHLVVA 300
    DLFSAGMVTT SITLAWGLLL MILHPDVQRR VQQEIDDVIG RVRRPEMGDQ 350
    TYMPYTTAVI HEVQRFADIV PLGVTHMTSR DIEVQGFLIP KGTTLFTNLS 400
    SVLKDEANWE KPFRFHPEHF LDAQGRFVKP EAFLPFSAGR RACLGEPLAR 450
    MELFLFFTCL LQRFSFSVPA GQPRPSPHGV FAFLVTPSPY ELCAVPR 497
    Length:497
    Mass (Da):55,912
    Last modified:January 1, 1998 - v1
    Checksum:iA482AEE71E4D6CAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D29822 mRNA. Translation: BAA22155.1.
    RefSeqiNP_001191367.1. NM_001204438.1.

    Genome annotation databases

    GeneIDi100385343.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D29822 mRNA. Translation: BAA22155.1 .
    RefSeqi NP_001191367.1. NM_001204438.1.

    3D structure databases

    ProteinModelPortali O18992.
    SMRi O18992. Positions 34-497.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100385343.

    Organism-specific databases

    CTDi 100385343.

    Phylogenomic databases

    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs."
      Igarashi T., Sakuma T., Isogai M., Nagata R., Kamataki T.
      Arch. Biochem. Biophys. 339:85-91(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2DJ_CALJA
    AccessioniPrimary (citable) accession number: O18992
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3