Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O18992 (CP2DJ_CALJA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2D19

EC=1.14.14.1
Alternative name(s):
CYPIID19
Cytochrome P450 CM2D-1
Gene names
Name:CYP2D19
OrganismCallithrix jacchus (White-tufted-ear marmoset) [Reference proteome]
Taxonomic identifier9483 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Cytochrome P450 2D19
PRO_0000051743

Sites

Metal binding4431Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O18992 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: A482AEE71E4D6CAF

FASTA49755,912
        10         20         30         40         50         60 
MGLDALVPLA VTVAIFVLLV DLMHRRQRWA ARYPPGPMPL PGLGNLLHVD FQNTPNSFNQ 

        70         80         90        100        110        120 
LRRRFGDVFS LQLAWTPVVV LNGLEAVREA LVTRGEDTAD RPPVPITEML GFGPHSQGLF 

       130        140        150        160        170        180 
LARYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEATYL CAAFADHAGR PFRPNGLLDK 

       190        200        210        220        230        240 
AVSNVIASLT CRRRFEYNDP CLLRLLDLTM EGLKEESGLL REVLNAIPVL LRIPGLAGKV 

       250        260        270        280        290        300 
LRSQKAFLAQ LDELLTEHRM TWDPAQPPRD LTEAFLAEME KTKGNPESSF NDENLHLVVA 

       310        320        330        340        350        360 
DLFSAGMVTT SITLAWGLLL MILHPDVQRR VQQEIDDVIG RVRRPEMGDQ TYMPYTTAVI 

       370        380        390        400        410        420 
HEVQRFADIV PLGVTHMTSR DIEVQGFLIP KGTTLFTNLS SVLKDEANWE KPFRFHPEHF 

       430        440        450        460        470        480 
LDAQGRFVKP EAFLPFSAGR RACLGEPLAR MELFLFFTCL LQRFSFSVPA GQPRPSPHGV 

       490 
FAFLVTPSPY ELCAVPR 

« Hide

References

[1]"Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs."
Igarashi T., Sakuma T., Isogai M., Nagata R., Kamataki T.
Arch. Biochem. Biophys. 339:85-91(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D29822 mRNA. Translation: BAA22155.1.
RefSeqNP_001191367.1. NM_001204438.1.

3D structure databases

ProteinModelPortalO18992.
SMRO18992. Positions 34-497.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100385343.

Organism-specific databases

CTD100385343.

Phylogenomic databases

HOGENOMHOG000036991.
HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2DJ_CALJA
AccessionPrimary (citable) accession number: O18992
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: December 11, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families