O18992 (CP2DJ_CALJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 2D19
EC=1.14.14.1

Alternative name(s):
CYPIID19
Cytochrome P450 CM2D-1

Gene names

Name:

CYP2D19

Organism

Callithrix jacchus (White-tufted-ear marmoset) [Reference proteome]

Taxonomic identifier

9483 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Platyrrhini › Cebidae › Callitrichinae › Callithrix

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	alkaloid catabolic process Inferred from electronic annotation. Source: Compara coumarin metabolic process Inferred from electronic annotation. Source: Compara drug catabolic process Inferred from electronic annotation. Source: Compara isoquinoline alkaloid metabolic process Inferred from electronic annotation. Source: Compara monoterpenoid metabolic process Inferred from electronic annotation. Source: Compara negative regulation of binding Inferred from electronic annotation. Source: Compara negative regulation of cellular organofluorine metabolic process Inferred from electronic annotation. Source: Compara oxidative demethylation Inferred from electronic annotation. Source: Compara steroid metabolic process Inferred from electronic annotation. Source: Compara
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from electronic annotation. Source: Compara
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC drug binding Inferred from electronic annotation. Source: Compara electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: Compara iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Cytochrome P450 2D19		PRO_0000051743
Sites
	Metal binding	443	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O18992 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: A482AEE71E4D6CAF	FASTA	497	55,912
	10 20 30 40 50 60 MGLDALVPLA VTVAIFVLLV DLMHRRQRWA ARYPPGPMPL PGLGNLLHVD FQNTPNSFNQ 70 80 90 100 110 120 LRRRFGDVFS LQLAWTPVVV LNGLEAVREA LVTRGEDTAD RPPVPITEML GFGPHSQGLF 130 140 150 160 170 180 LARYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEATYL CAAFADHAGR PFRPNGLLDK 190 200 210 220 230 240 AVSNVIASLT CRRRFEYNDP CLLRLLDLTM EGLKEESGLL REVLNAIPVL LRIPGLAGKV 250 260 270 280 290 300 LRSQKAFLAQ LDELLTEHRM TWDPAQPPRD LTEAFLAEME KTKGNPESSF NDENLHLVVA 310 320 330 340 350 360 DLFSAGMVTT SITLAWGLLL MILHPDVQRR VQQEIDDVIG RVRRPEMGDQ TYMPYTTAVI 370 380 390 400 410 420 HEVQRFADIV PLGVTHMTSR DIEVQGFLIP KGTTLFTNLS SVLKDEANWE KPFRFHPEHF 430 440 450 460 470 480 LDAQGRFVKP EAFLPFSAGR RACLGEPLAR MELFLFFTCL LQRFSFSVPA GQPRPSPHGV 490 FAFLVTPSPY ELCAVPR

References

[1]	"Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs." Igarashi T., Sakuma T., Isogai M., Nagata R., Kamataki T. Arch. Biochem. Biophys. 339:85-91(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D29822 mRNA. Translation: BAA22155.1.
RefSeq	NP_001191367.1. NM_001204438.1.
3D structure databases
ProteinModelPortal	O18992.
SMR	O18992. Positions 34-497.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100385343.
Organism-specific databases
CTD	100385343.
Phylogenomic databases
HOGENOM	HOG000036991.
HOVERGEN	HBG015789.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008069. Cyt_P450_E_grp-I_CYP2D-like. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01686. EP450ICYP2D. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP2DJ_CALJA

Accession

Primary (citable) accession number: O18992

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program