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Protein

Cytochrome P450 2D19

Gene

CYP2D19

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi443 – 4431Iron (heme axial ligand)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D19 (EC:1.14.14.1)
Alternative name(s):
CYPIID19
Cytochrome P450 CM2D-1
Gene namesi
Name:CYP2D19
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
ProteomesiUP000008225 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Cytochrome P450 2D19PRO_0000051743Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliO18992.
SMRiO18992. Positions 34-497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiO18992.
KOiK07414.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLDALVPLA VTVAIFVLLV DLMHRRQRWA ARYPPGPMPL PGLGNLLHVD
60 70 80 90 100
FQNTPNSFNQ LRRRFGDVFS LQLAWTPVVV LNGLEAVREA LVTRGEDTAD
110 120 130 140 150
RPPVPITEML GFGPHSQGLF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE
160 170 180 190 200
QWVTEEATYL CAAFADHAGR PFRPNGLLDK AVSNVIASLT CRRRFEYNDP
210 220 230 240 250
CLLRLLDLTM EGLKEESGLL REVLNAIPVL LRIPGLAGKV LRSQKAFLAQ
260 270 280 290 300
LDELLTEHRM TWDPAQPPRD LTEAFLAEME KTKGNPESSF NDENLHLVVA
310 320 330 340 350
DLFSAGMVTT SITLAWGLLL MILHPDVQRR VQQEIDDVIG RVRRPEMGDQ
360 370 380 390 400
TYMPYTTAVI HEVQRFADIV PLGVTHMTSR DIEVQGFLIP KGTTLFTNLS
410 420 430 440 450
SVLKDEANWE KPFRFHPEHF LDAQGRFVKP EAFLPFSAGR RACLGEPLAR
460 470 480 490
MELFLFFTCL LQRFSFSVPA GQPRPSPHGV FAFLVTPSPY ELCAVPR
Length:497
Mass (Da):55,912
Last modified:January 1, 1998 - v1
Checksum:iA482AEE71E4D6CAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29822 mRNA. Translation: BAA22155.1.
RefSeqiNP_001191367.1. NM_001204438.1.

Genome annotation databases

GeneIDi100385343.
KEGGicjc:100385343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29822 mRNA. Translation: BAA22155.1.
RefSeqiNP_001191367.1. NM_001204438.1.

3D structure databases

ProteinModelPortaliO18992.
SMRiO18992. Positions 34-497.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100385343.
KEGGicjc:100385343.

Organism-specific databases

CTDi100385343.

Phylogenomic databases

HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiO18992.
KOiK07414.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs."
    Igarashi T., Sakuma T., Isogai M., Nagata R., Kamataki T.
    Arch. Biochem. Biophys. 339:85-91(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP2DJ_CALJA
AccessioniPrimary (citable) accession number: O18992
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: April 29, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.