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Protein
Submitted name:

Na-K-Cl cotransporter

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Na-K-Cl cotransporterImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei277 – 298HelicalSequence analysisAdd BLAST22
Transmembranei310 – 339HelicalSequence analysisAdd BLAST30
Transmembranei359 – 380HelicalSequence analysisAdd BLAST22
Transmembranei401 – 420HelicalSequence analysisAdd BLAST20
Transmembranei426 – 449HelicalSequence analysisAdd BLAST24
Transmembranei478 – 497HelicalSequence analysisAdd BLAST20
Transmembranei517 – 537HelicalSequence analysisAdd BLAST21
Transmembranei647 – 667HelicalSequence analysisAdd BLAST21
Transmembranei673 – 691HelicalSequence analysisAdd BLAST19
Transmembranei703 – 722HelicalSequence analysisAdd BLAST20
Transmembranei728 – 743HelicalSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiO18978

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini194 – 247AA_permease_NInterPro annotationAdd BLAST54
Domaini282 – 784AA_permeaseInterPro annotationAdd BLAST503
Domaini793 – 1201SLC12InterPro annotationAdd BLAST409

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2083 Eukaryota
COG0531 LUCA
HOGENOMiHOG000062855
HOVERGENiHBG052851
KOiK10951

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR013612 AA_permease_N
IPR002443 Na/K/Cl_cotranspt
IPR002444 NKCC1
IPR018491 SLC12_C
IPR004842 SLC12A_fam
PANTHERiPTHR11827:SF58 PTHR11827:SF58, 1 hit
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PF08403 AA_permease_N, 1 hit
PF03522 SLC12, 1 hit
PRINTSiPR01207 NAKCLTRNSPRT
PR01208 NAKCLTRSPRT1
TIGRFAMsiTIGR00930 2a30, 1 hit

Sequencei

Sequence statusi: Complete.

O18978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGPTAPSS GAPRLAGVGE TPPVAPLAAA GMDLPGTAVP SVPEDAAAVS
60 70 80 90 100
RGGGGVRGEG AAAAGDGLGR PLGPTPSQSR FQVDLVSENA GRAAAAAASA
110 120 130 140 150
GAGGKETPAD GKASVESGQA KASEEAKGRF RVNFVDPAAS SSADESVSDA
160 170 180 190 200
AGIGGDGPNV SFQNGGDTVL SEGSSLHSGG GGGGSGHHQH YYYDTHTNTY
210 220 230 240 250
YLRTFGHNTM DAVPRIDHYR HTAAQLGEKL LRPSLAELHD ELEKEPFEDG
260 270 280 290 300
FANGEESTPT REAVVTYTAE SKGVVKFGWI KGVLVRCMLN IWGVMLFIRL
310 320 330 340 350
SWIVGQAGIG LSVIVIAMAT VVTTITGLST SAIATNGFVR GGGAYYLISR
360 370 380 390 400
SLGPEFGGAI GLIFAFANAV AVAMYVVGFA ETVVELLKEH SILMIDEIND
410 420 430 440 450
IRIIGAITVV ILLGISVAGM EWEAKAQIVL LVILLLAIAD FVIGTFIPLE
460 470 480 490 500
SKKPKGFFGY KYEIFSENFG PDFREEETFF SVFAIFFPAA TGILAGANIS
510 520 530 540 550
GDLADPQSAI PKGTPLAILI TTLVYIGIAV SVGSCVVRDA TGNVNDTIVT
560 570 580 590 600
ELTNCTSAAC KLNFDFSSCE TNPCSYGLMN NFQVMSMVSG FAPLISAGIF
610 620 630 640 650
SATLSSALAS LVSAPKIFQA LCKDNIYPAF QMFAKGYGKN NEPLRGYILT
660 670 680 690 700
FLIALGFILI AELNVIAPII SNFFLASYAL INFSVFHASL AKSPGWRPAF
710 720 730 740 750
KYYNMWISLL GAILCCIVMF VINWWAALLT YVIVLGLYIY VTYKKPDVNW
760 770 780 790 800
GSSTQALTYL NALQHSIRLS GVEDHVKNFR PQCLVMTGAP NSRPALLHLV
810 820 830 840 850
HDFTKNVGLM ICGHVHMGPR RQAMKEMSID QAKYQRWLIK NKMKAFYAPV
860 870 880 890 900
HADDLREGAQ YLMQAAGLGR MKPNTLVLGF KKDWLQADMR DVDMYINLFH
910 920 930 940 950
DAFDIQYGVV VIRLQEGLDI SHLQGQEELL SSQEKSPGVK DVVLSVEYSK
960 970 980 990 1000
KSDLDTSKPS SEKSITHKED GKTPIQPLLK KESKGPAVPL NVADQKLLEA
1010 1020 1030 1040 1050
STQFQKKQGK NTIDVWWLFD DGGLTLLIPY LLTTKKKWKD CKIRVFIGGK
1060 1070 1080 1090 1100
INRIDHDRRA MPTLLTKFRI DFSDIMVLGD INTKPKKENI VAFDEMIEPY
1110 1120 1130 1140 1150
RLHEDDKEQD IADKMKEDEP WRITDNELEL YKTKTYRQIR LNELLKEHSN
1160 1170 1180 1190 1200
TANIIVMSLP VARKGAVSSA LYMAWLEALS KDLPPILLVR GNHQSVLTFY

S
Length:1,201
Mass (Da):130,394
Last modified:January 1, 1998 - v1
Checksum:iA3EBE1E79D2A50B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70138 mRNA Translation: AAC48754.1
RefSeqiNP_777207.1, NM_174782.3
UniGeneiBt.4793

Genome annotation databases

GeneIDi286845
KEGGibta:286845

Similar proteinsi

Entry informationi

Entry nameiO18978_BOVIN
AccessioniPrimary (citable) accession number: O18978
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health