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Protein
Submitted name:

Na-K-Cl cotransporter

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Na-K-Cl cotransporterImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei277 – 29822HelicalSequence analysisAdd
BLAST
Transmembranei310 – 33930HelicalSequence analysisAdd
BLAST
Transmembranei359 – 38022HelicalSequence analysisAdd
BLAST
Transmembranei401 – 42020HelicalSequence analysisAdd
BLAST
Transmembranei426 – 44924HelicalSequence analysisAdd
BLAST
Transmembranei478 – 49720HelicalSequence analysisAdd
BLAST
Transmembranei517 – 53721HelicalSequence analysisAdd
BLAST
Transmembranei647 – 66721HelicalSequence analysisAdd
BLAST
Transmembranei673 – 69119HelicalSequence analysisAdd
BLAST
Transmembranei703 – 72220HelicalSequence analysisAdd
BLAST
Transmembranei728 – 74316HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO18978.
PRIDEiO18978.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012701.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini194 – 25360AA_permease_NInterPro annotationAdd
BLAST
Domaini282 – 784503AA_permeaseInterPro annotationAdd
BLAST
Domaini793 – 1201409SLC12InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2083. Eukaryota.
COG0531. LUCA.
HOGENOMiHOG000062855.
HOVERGENiHBG052851.
KOiK10951.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR013612. AA_permease_N.
IPR002443. Na/K/Cl_cotranspt.
IPR002444. NKCC1.
IPR018491. SLC12_C.
IPR004842. SLC12A_fam.
[Graphical view]
PfamiPF00324. AA_permease. 1 hit.
PF08403. AA_permease_N. 1 hit.
PF03522. SLC12. 1 hit.
[Graphical view]
PRINTSiPR01207. NAKCLTRNSPRT.
PR01208. NAKCLTRSPRT1.
TIGRFAMsiTIGR00930. 2a30. 1 hit.

Sequencei

Sequence statusi: Complete.

O18978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGPTAPSS GAPRLAGVGE TPPVAPLAAA GMDLPGTAVP SVPEDAAAVS
60 70 80 90 100
RGGGGVRGEG AAAAGDGLGR PLGPTPSQSR FQVDLVSENA GRAAAAAASA
110 120 130 140 150
GAGGKETPAD GKASVESGQA KASEEAKGRF RVNFVDPAAS SSADESVSDA
160 170 180 190 200
AGIGGDGPNV SFQNGGDTVL SEGSSLHSGG GGGGSGHHQH YYYDTHTNTY
210 220 230 240 250
YLRTFGHNTM DAVPRIDHYR HTAAQLGEKL LRPSLAELHD ELEKEPFEDG
260 270 280 290 300
FANGEESTPT REAVVTYTAE SKGVVKFGWI KGVLVRCMLN IWGVMLFIRL
310 320 330 340 350
SWIVGQAGIG LSVIVIAMAT VVTTITGLST SAIATNGFVR GGGAYYLISR
360 370 380 390 400
SLGPEFGGAI GLIFAFANAV AVAMYVVGFA ETVVELLKEH SILMIDEIND
410 420 430 440 450
IRIIGAITVV ILLGISVAGM EWEAKAQIVL LVILLLAIAD FVIGTFIPLE
460 470 480 490 500
SKKPKGFFGY KYEIFSENFG PDFREEETFF SVFAIFFPAA TGILAGANIS
510 520 530 540 550
GDLADPQSAI PKGTPLAILI TTLVYIGIAV SVGSCVVRDA TGNVNDTIVT
560 570 580 590 600
ELTNCTSAAC KLNFDFSSCE TNPCSYGLMN NFQVMSMVSG FAPLISAGIF
610 620 630 640 650
SATLSSALAS LVSAPKIFQA LCKDNIYPAF QMFAKGYGKN NEPLRGYILT
660 670 680 690 700
FLIALGFILI AELNVIAPII SNFFLASYAL INFSVFHASL AKSPGWRPAF
710 720 730 740 750
KYYNMWISLL GAILCCIVMF VINWWAALLT YVIVLGLYIY VTYKKPDVNW
760 770 780 790 800
GSSTQALTYL NALQHSIRLS GVEDHVKNFR PQCLVMTGAP NSRPALLHLV
810 820 830 840 850
HDFTKNVGLM ICGHVHMGPR RQAMKEMSID QAKYQRWLIK NKMKAFYAPV
860 870 880 890 900
HADDLREGAQ YLMQAAGLGR MKPNTLVLGF KKDWLQADMR DVDMYINLFH
910 920 930 940 950
DAFDIQYGVV VIRLQEGLDI SHLQGQEELL SSQEKSPGVK DVVLSVEYSK
960 970 980 990 1000
KSDLDTSKPS SEKSITHKED GKTPIQPLLK KESKGPAVPL NVADQKLLEA
1010 1020 1030 1040 1050
STQFQKKQGK NTIDVWWLFD DGGLTLLIPY LLTTKKKWKD CKIRVFIGGK
1060 1070 1080 1090 1100
INRIDHDRRA MPTLLTKFRI DFSDIMVLGD INTKPKKENI VAFDEMIEPY
1110 1120 1130 1140 1150
RLHEDDKEQD IADKMKEDEP WRITDNELEL YKTKTYRQIR LNELLKEHSN
1160 1170 1180 1190 1200
TANIIVMSLP VARKGAVSSA LYMAWLEALS KDLPPILLVR GNHQSVLTFY

S
Length:1,201
Mass (Da):130,394
Last modified:January 1, 1998 - v1
Checksum:iA3EBE1E79D2A50B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70138 mRNA. Translation: AAC48754.1.
RefSeqiNP_777207.1. NM_174782.3.
UniGeneiBt.4793.

Genome annotation databases

GeneIDi286845.
KEGGibta:286845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70138 mRNA. Translation: AAC48754.1.
RefSeqiNP_777207.1. NM_174782.3.
UniGeneiBt.4793.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012701.

Proteomic databases

PaxDbiO18978.
PRIDEiO18978.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi286845.
KEGGibta:286845.

Organism-specific databases

CTDi6558.

Phylogenomic databases

eggNOGiKOG2083. Eukaryota.
COG0531. LUCA.
HOGENOMiHOG000062855.
HOVERGENiHBG052851.
KOiK10951.

Miscellaneous databases

NextBioi20806496.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR013612. AA_permease_N.
IPR002443. Na/K/Cl_cotranspt.
IPR002444. NKCC1.
IPR018491. SLC12_C.
IPR004842. SLC12A_fam.
[Graphical view]
PfamiPF00324. AA_permease. 1 hit.
PF08403. AA_permease_N. 1 hit.
PF03522. SLC12. 1 hit.
[Graphical view]
PRINTSiPR01207. NAKCLTRNSPRT.
PR01208. NAKCLTRSPRT1.
TIGRFAMsiTIGR00930. 2a30. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of the Na-K-Cl cotransporter of bovine aortic endothelial cells."
    Yerby T.R., Vibat C.R.T., Sun D., Payne J.A., O'Donnell M.E.
    Am. J. Physiol. 273:0-0(1997)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: AortaImported.

Entry informationi

Entry nameiO18978_BOVIN
AccessioniPrimary (citable) accession number: O18978
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: March 16, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.