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Protein

Cytochrome P450 2E1

Gene

CYP2E1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites.By similarity

Catalytic activityi

4-nitrophenol + NADPH + O2 = 4-nitrocatechol + NADP+ + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi437Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2E1 (EC:1.14.13.-)
Alternative name(s):
4-nitrophenol 2-hydroxylase (EC:1.14.13.n7)
CYPIIE1
Gene namesi
Name:CYP2E1
Synonyms:CYP2E
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517501 – 495Cytochrome P450 2E1Add BLAST495

Proteomic databases

PaxDbiO18963.
PeptideAtlasiO18963.
PRIDEiO18963.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024437.

Structurei

3D structure databases

ProteinModelPortaliO18963.
SMRiO18963.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni298 – 303Substrate bindingBy similarity6

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiO18963.
KOiK07415.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008070. Cyt_P450_E_grp-I_CYP2E-like.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01687. EP450ICYP2E.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

O18963-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALGITVAL LVWMATLLFI SIWKHIYSSW KLPPGPFPLP IIGNLLQLDI
60 70 80 90 100
KNIPKSFTRL AERYGPVFTL YLGSQRAVVV HGYKPVKEVL LDYKNEFSGR
110 120 130 140 150
GENPGFQMHK NNGIIFNNGS TWRDTRRFSL TTLRDLGMGK QGNEQRIQRE
160 170 180 190 200
AHFLLEVLRK TQGQPFDPTF VVGFAPYNVI SDILFHKRFD YKDQTSLRLM
210 220 230 240 250
SLFNENFYLL SSPWIQLYNN FPDYLQYLPG SHRKLLKNVS EVKSYALERV
260 270 280 290 300
KDHQKSLEPS CPRGFLDTML IEMAKERHSV DPMYTLENIA VTVADLLFAG
310 320 330 340 350
TETTSTTLRY GLLILMKYPE VEEKLHEEID RVIGPSRIPA VKDRLDMPYL
360 370 380 390 400
DAVVHEIQRF IDLLPSNLLH EATQDTVFRG YVIPKGTVVI PTLDSVLHDR
410 420 430 440 450
QEFPEPEKFK PEHFLNENGK FKYSDHFKAF SAGKRVCVGE GLARMELFLL
460 470 480 490
LAAILQHFNL KSLVDPKDID LSPIAIGFGK IPPRYKLCLI PRSKV
Length:495
Mass (Da):56,827
Last modified:January 1, 1998 - v1
Checksum:i0055EB5EB6FCE1AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001715 mRNA. Translation: CAA04948.1.
DQ058608 mRNA. Translation: AAY83882.1.
DQ058605 Genomic DNA. Translation: AAY83880.1.
RefSeqiNP_776955.2. NM_174530.3.
UniGeneiBt.5532.

Genome annotation databases

GeneIDi282213.
KEGGibta:282213.

Similar proteinsi

Entry informationi

Entry nameiCP2E1_BOVIN
AccessioniPrimary (citable) accession number: O18963
Secondary accession number(s): Q4PS78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families