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O18956 (ENTP1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ectonucleoside triphosphate diphosphohydrolase 1

Short name=NTPDase 1
EC=3.6.1.5
Alternative name(s):
Ecto-ATP diphosphohydrolase 1
Short name=Ecto-ATPDase 1
Short name=Ecto-ATPase 1
Ecto-apyrase
Lymphoid cell activation antigen
CD_antigen=CD39
Gene names
Name:ENTPD1
Synonyms:CD39
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Catalytic activity

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

Cofactor

Ca2+ or Mg2+ By similarity.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the GDA1/CD39 NTPase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Ectonucleoside triphosphate diphosphohydrolase 1
PRO_0000209901

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 3721Helical; Potential
Topological domain38 – 481444Extracellular Potential
Transmembrane482 – 50221Helical; Potential
Topological domain503 – 51311Cytoplasmic Potential

Sites

Active site1741Proton acceptor By similarity

Amino acid modifications

Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation2271N-linked (GlcNAc...) Potential
Glycosylation2451N-linked (GlcNAc...) Potential
Glycosylation3071N-linked (GlcNAc...) Potential
Glycosylation3361N-linked (GlcNAc...) Potential
Glycosylation3731N-linked (GlcNAc...) Potential
Glycosylation4601N-linked (GlcNAc...) Potential
Disulfide bond255 ↔ 300 By similarity
Disulfide bond281 ↔ 327 By similarity
Disulfide bond340 ↔ 345 By similarity
Disulfide bond393 ↔ 416 By similarity

Experimental info

Sequence conflict971K → N AA sequence Ref.2
Sequence conflict101 – 1033INV → CGF AA sequence Ref.2
Sequence conflict4641K → V AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
O18956 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 20FE98F27B6D2F96

FASTA51358,114
        10         20         30         40         50         60 
MEDRRESELK VFCSKNILSI LGFSCIIAVI ALLALGLTQN KALPENVKFG IVLDAGSSHT 

        70         80         90        100        110        120 
SLYIYRWPAE KENDTGVVTQ IEESNVKGPG ISGFAKKVNE INVYLTACME RAQKVIPSIQ 

       130        140        150        160        170        180 
HMETPVYLGA TAGMRLLRME NKQMADKILA AVASSISEYP FDFQGARIIS GQEEGAYGWI 

       190        200        210        220        230        240 
TVNYLLGKFT QKLSWFNLKP SKDDTQETYG ALDLGGASTQ ITFVPQNETT ESPNNNLYFR 

       250        260        270        280        290        300 
LYGKNYSVYT HSFLCYGKDQ ALLQKLALGL QGTNGIIHEP CFHSRYMRKI KMSVLNEGFC 

       310        320        330        340        350        360 
TKRHELNSSF YPLVDIEIRG AGNFQRCRQS IIQLFNTSYC PYSSCSFNGV FLPPLHGQFG 

       370        380        390        400        410        420 
AFSAFYYVME FLNLTSEESV SVEQLTEKLE EFCAQRWEEV QKNFGEVKEK YLSEYCFSGT 

       430        440        450        460        470        480 
YILVLLLNGY HFTAESWKNI HFMNKVRSTD VGWTLGYMLN LTNKIPAEEP MSPPLPHSTY 

       490        500        510 
VFLMVLFSLI LLAVIIVGIV VFHKPSYFWK DMV 

« Hide

References

[1]Chang A.S., Garcia R.L., Chang S.M., Schilling W.P.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Aortic endothelium.
[2]"Identification and characterization of CD39/vascular ATP diphosphohydrolase."
Kaczmarek E., Koziak K., Sevigny J., Siegel J.B., Anrather J., Beaudoin A.R., Bach F.H., Robson S.C.
J. Biol. Chem. 271:33116-33122(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 97-103; 123-133; 136-140; 145-168 AND 459-471.
Tissue: Aorta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF005940 mRNA. Translation: AAB62382.1.
RefSeqNP_776961.1. NM_174536.2.
UniGeneBt.4117.

3D structure databases

ProteinModelPortalO18956.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000045026.

Chemistry

BindingDBO18956.
ChEMBLCHEMBL2766.

Proteomic databases

PRIDEO18956.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID282223.
KEGGbta:282223.

Organism-specific databases

CTD953.

Phylogenomic databases

eggNOGCOG5371.
HOGENOMHOG000059572.
HOVERGENHBG018982.
KOK01510.

Family and domain databases

InterProIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERPTHR11782. PTHR11782. 1 hit.
PfamPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806045.

Entry information

Entry nameENTP1_BOVIN
AccessionPrimary (citable) accession number: O18956
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families