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O18956

- ENTP1_BOVIN

UniProt

O18956 - ENTP1_BOVIN

Protein

Ectonucleoside triphosphate diphosphohydrolase 1

Gene

ENTPD1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

    Catalytic activityi

    A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

    Cofactori

    Ca2+ or Mg2+.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei174 – 1741Proton acceptorBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Calcium, Magnesium, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 1 (EC:3.6.1.5)
    Short name:
    NTPDase 1
    Alternative name(s):
    Ecto-ATP diphosphohydrolase 1
    Short name:
    Ecto-ATPDase 1
    Short name:
    Ecto-ATPase 1
    Ecto-apyrase
    Lymphoid cell activation antigen
    CD_antigen: CD39
    Gene namesi
    Name:ENTPD1
    Synonyms:CD39
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Ectonucleoside triphosphate diphosphohydrolase 1PRO_0000209901Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi255 ↔ 300By similarity
    Disulfide bondi281 ↔ 327By similarity
    Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi340 ↔ 345By similarity
    Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi393 ↔ 416By similarity
    Glycosylationi460 – 4601N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO18956.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000045026.

    Structurei

    3D structure databases

    ProteinModelPortaliO18956.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini38 – 481444ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini503 – 51311CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei482 – 50221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GDA1/CD39 NTPase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5371.
    HOGENOMiHOG000059572.
    HOVERGENiHBG018982.
    KOiK01510.

    Family and domain databases

    InterProiIPR000407. GDA1_CD39_NTPase.
    [Graphical view]
    PANTHERiPTHR11782. PTHR11782. 1 hit.
    PfamiPF01150. GDA1_CD39. 1 hit.
    [Graphical view]
    PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O18956-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDRRESELK VFCSKNILSI LGFSCIIAVI ALLALGLTQN KALPENVKFG    50
    IVLDAGSSHT SLYIYRWPAE KENDTGVVTQ IEESNVKGPG ISGFAKKVNE 100
    INVYLTACME RAQKVIPSIQ HMETPVYLGA TAGMRLLRME NKQMADKILA 150
    AVASSISEYP FDFQGARIIS GQEEGAYGWI TVNYLLGKFT QKLSWFNLKP 200
    SKDDTQETYG ALDLGGASTQ ITFVPQNETT ESPNNNLYFR LYGKNYSVYT 250
    HSFLCYGKDQ ALLQKLALGL QGTNGIIHEP CFHSRYMRKI KMSVLNEGFC 300
    TKRHELNSSF YPLVDIEIRG AGNFQRCRQS IIQLFNTSYC PYSSCSFNGV 350
    FLPPLHGQFG AFSAFYYVME FLNLTSEESV SVEQLTEKLE EFCAQRWEEV 400
    QKNFGEVKEK YLSEYCFSGT YILVLLLNGY HFTAESWKNI HFMNKVRSTD 450
    VGWTLGYMLN LTNKIPAEEP MSPPLPHSTY VFLMVLFSLI LLAVIIVGIV 500
    VFHKPSYFWK DMV 513
    Length:513
    Mass (Da):58,114
    Last modified:January 1, 1998 - v1
    Checksum:i20FE98F27B6D2F96
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 971K → N AA sequence (PubMed:8955160)Curated
    Sequence conflicti101 – 1033INV → CGF AA sequence (PubMed:8955160)Curated
    Sequence conflicti464 – 4641K → V AA sequence (PubMed:8955160)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF005940 mRNA. Translation: AAB62382.1.
    RefSeqiNP_776961.1. NM_174536.2.
    UniGeneiBt.4117.

    Genome annotation databases

    GeneIDi282223.
    KEGGibta:282223.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF005940 mRNA. Translation: AAB62382.1 .
    RefSeqi NP_776961.1. NM_174536.2.
    UniGenei Bt.4117.

    3D structure databases

    ProteinModelPortali O18956.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000045026.

    Chemistry

    BindingDBi O18956.
    ChEMBLi CHEMBL2766.

    Proteomic databases

    PRIDEi O18956.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 282223.
    KEGGi bta:282223.

    Organism-specific databases

    CTDi 953.

    Phylogenomic databases

    eggNOGi COG5371.
    HOGENOMi HOG000059572.
    HOVERGENi HBG018982.
    KOi K01510.

    Miscellaneous databases

    NextBioi 20806045.

    Family and domain databases

    InterProi IPR000407. GDA1_CD39_NTPase.
    [Graphical view ]
    PANTHERi PTHR11782. PTHR11782. 1 hit.
    Pfami PF01150. GDA1_CD39. 1 hit.
    [Graphical view ]
    PROSITEi PS01238. GDA1_CD39_NTPASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Chang A.S., Garcia R.L., Chang S.M., Schilling W.P.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Aortic endothelium.
    2. "Identification and characterization of CD39/vascular ATP diphosphohydrolase."
      Kaczmarek E., Koziak K., Sevigny J., Siegel J.B., Anrather J., Beaudoin A.R., Bach F.H., Robson S.C.
      J. Biol. Chem. 271:33116-33122(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 97-103; 123-133; 136-140; 145-168 AND 459-471.
      Tissue: Aorta.

    Entry informationi

    Entry nameiENTP1_BOVIN
    AccessioniPrimary (citable) accession number: O18956
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3