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O18956

- ENTP1_BOVIN

UniProt

O18956 - ENTP1_BOVIN

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Protein

Ectonucleoside triphosphate diphosphohydrolase 1

Gene
ENTPD1, CD39
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Catalytic activityi

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

Cofactori

Ca2+ or Mg2+ By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei174 – 1741Proton acceptor By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 1 (EC:3.6.1.5)
Short name:
NTPDase 1
Alternative name(s):
Ecto-ATP diphosphohydrolase 1
Short name:
Ecto-ATPDase 1
Short name:
Ecto-ATPase 1
Ecto-apyrase
Lymphoid cell activation antigen
CD_antigen: CD39
Gene namesi
Name:ENTPD1
Synonyms:CD39
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei17 – 3721Helical; Reviewed predictionAdd
BLAST
Topological domaini38 – 481444Extracellular Reviewed predictionAdd
BLAST
Transmembranei482 – 50221Helical; Reviewed predictionAdd
BLAST
Topological domaini503 – 51311Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Ectonucleoside triphosphate diphosphohydrolase 1PRO_0000209901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi227 – 2271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi245 – 2451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi255 ↔ 300 By similarity
Disulfide bondi281 ↔ 327 By similarity
Glycosylationi307 – 3071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi336 – 3361N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi340 ↔ 345 By similarity
Glycosylationi373 – 3731N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi393 ↔ 416 By similarity
Glycosylationi460 – 4601N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO18956.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045026.

Structurei

3D structure databases

ProteinModelPortaliO18956.

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5371.
HOGENOMiHOG000059572.
HOVERGENiHBG018982.
KOiK01510.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 1 hit.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18956-1 [UniParc]FASTAAdd to Basket

« Hide

MEDRRESELK VFCSKNILSI LGFSCIIAVI ALLALGLTQN KALPENVKFG    50
IVLDAGSSHT SLYIYRWPAE KENDTGVVTQ IEESNVKGPG ISGFAKKVNE 100
INVYLTACME RAQKVIPSIQ HMETPVYLGA TAGMRLLRME NKQMADKILA 150
AVASSISEYP FDFQGARIIS GQEEGAYGWI TVNYLLGKFT QKLSWFNLKP 200
SKDDTQETYG ALDLGGASTQ ITFVPQNETT ESPNNNLYFR LYGKNYSVYT 250
HSFLCYGKDQ ALLQKLALGL QGTNGIIHEP CFHSRYMRKI KMSVLNEGFC 300
TKRHELNSSF YPLVDIEIRG AGNFQRCRQS IIQLFNTSYC PYSSCSFNGV 350
FLPPLHGQFG AFSAFYYVME FLNLTSEESV SVEQLTEKLE EFCAQRWEEV 400
QKNFGEVKEK YLSEYCFSGT YILVLLLNGY HFTAESWKNI HFMNKVRSTD 450
VGWTLGYMLN LTNKIPAEEP MSPPLPHSTY VFLMVLFSLI LLAVIIVGIV 500
VFHKPSYFWK DMV 513
Length:513
Mass (Da):58,114
Last modified:January 1, 1998 - v1
Checksum:i20FE98F27B6D2F96
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971K → N AA sequence 1 Publication
Sequence conflicti101 – 1033INV → CGF AA sequence 1 Publication
Sequence conflicti464 – 4641K → V AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005940 mRNA. Translation: AAB62382.1.
RefSeqiNP_776961.1. NM_174536.2.
UniGeneiBt.4117.

Genome annotation databases

GeneIDi282223.
KEGGibta:282223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005940 mRNA. Translation: AAB62382.1 .
RefSeqi NP_776961.1. NM_174536.2.
UniGenei Bt.4117.

3D structure databases

ProteinModelPortali O18956.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000045026.

Chemistry

BindingDBi O18956.
ChEMBLi CHEMBL2766.

Proteomic databases

PRIDEi O18956.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 282223.
KEGGi bta:282223.

Organism-specific databases

CTDi 953.

Phylogenomic databases

eggNOGi COG5371.
HOGENOMi HOG000059572.
HOVERGENi HBG018982.
KOi K01510.

Miscellaneous databases

NextBioi 20806045.

Family and domain databases

InterProi IPR000407. GDA1_CD39_NTPase.
[Graphical view ]
PANTHERi PTHR11782. PTHR11782. 1 hit.
Pfami PF01150. GDA1_CD39. 1 hit.
[Graphical view ]
PROSITEi PS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Chang A.S., Garcia R.L., Chang S.M., Schilling W.P.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aortic endothelium.
  2. "Identification and characterization of CD39/vascular ATP diphosphohydrolase."
    Kaczmarek E., Koziak K., Sevigny J., Siegel J.B., Anrather J., Beaudoin A.R., Bach F.H., Robson S.C.
    J. Biol. Chem. 271:33116-33122(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 97-103; 123-133; 136-140; 145-168 AND 459-471.
    Tissue: Aorta.

Entry informationi

Entry nameiENTP1_BOVIN
AccessioniPrimary (citable) accession number: O18956
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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