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Protein

Anion exchange protein 3

Gene

SLC4A3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plasma membrane anion exchange protein.

GO - Molecular functioni

  1. inorganic anion exchanger activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 3
Short name:
AE 3
Short name:
Anion exchanger 3
Alternative name(s):
Anion exchanger 3 brain isoform
Neuronal band 3-like protein
Solute carrier family 4 member 3
Gene namesi
Name:SLC4A3
Synonyms:AE3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 709709CytoplasmicAdd
BLAST
Transmembranei710 – 73223HelicalSequence AnalysisAdd
BLAST
Transmembranei738 – 77538HelicalSequence AnalysisAdd
BLAST
Transmembranei795 – 81723HelicalSequence AnalysisAdd
BLAST
Transmembranei827 – 84822HelicalSequence AnalysisAdd
BLAST
Transmembranei894 – 91118HelicalSequence AnalysisAdd
BLAST
Topological domaini912 – 92615CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei927 – 94721HelicalSequence AnalysisAdd
BLAST
Transmembranei981 – 100323HelicalSequence AnalysisAdd
BLAST
Transmembranei1029 – 105022HelicalSequence AnalysisAdd
BLAST
Transmembranei1084 – 112946HelicalSequence AnalysisAdd
BLAST
Transmembranei1156 – 119237HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12331233Anion exchange protein 3PRO_0000079221Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi874 – 8741N-linked (GlcNAc...)Sequence Analysis
Lipidationi1166 – 11661S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Expressioni

Tissue specificityi

Neuronal.

Structurei

3D structure databases

ProteinModelPortaliO18917.
SMRiO18917. Positions 693-734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni710 – 1233524Membrane (anion exchange)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi74 – 8310His-rich
Compositional biasi136 – 15015Poly-GluAdd
BLAST
Compositional biasi203 – 2086Poly-Ser
Compositional biasi309 – 3124Poly-Lys
Compositional biasi443 – 4464Poly-Ser
Compositional biasi1185 – 11884Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268067.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiO18917.
KOiK13856.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANGVIPPPG GASPLPQVRV PLEEPPLSPD TEEEDDDLGK TLAVSRFGDL
60 70 80 90 100
ISKPPAWDPE KPSRSFSERD FAFHRHISHH THHPLSARLP PPHKLRRLPP
110 120 130 140 150
TFARHTRRKR KKEKTSAPPS EGTPPIQEEG GAGAHEGEEE EEEEEEGESE
160 170 180 190 200
TEAVEPPPSG SPQKAKFSIG SDEDDSPGLP GKAAFTKPLP SVGPRSDKSP
210 220 230 240 250
QRSVSSSSPR ARAPRVAGER SRPWSPSASY DLRERLCPGS ALGNPGGPEQ
260 270 280 290 300
QVPTDEAEAQ MLGSADLDDM KSHRLEDNPG VRRHLVKEPS RVQGGRGSRG
310 320 330 340 350
GLTPTLRRKK KKQQPDRRPH EVFVELNELM LDRSQEPHWR ETARWIKFEE
360 370 380 390 400
DVEEETERWG KPHVASLSFR SLLELRRTIA HGAALLDLEQ TTLPGIAHLV
410 420 430 440 450
VETMIVSDQI RPEDRASVLR TLLLKHCHPN DDKDCGSFPR NPSSSSVNSV
460 470 480 490 500
LGNHHATPSH GPDGAVPTMA DDLGEPAPLW PHDPDAKERP LHMPGGDGHR
510 520 530 540 550
GKSLKLLEKI PEDAEATVVL VGCVPFLEQP AAAFVRLSEA VLLESVLEVP
560 570 580 590 600
VPVRFLFVML GPSHISTDYH ELGRSIATLM SDKLFHEAAY QADDRQDLLG
610 620 630 640 650
AISEFLDGSI VIPPSEVEGR DLLRSVAAFQ RELLRKRRER EQTKVEMTTR
660 670 680 690 700
GGYLAPGKEL ALELGGSDAA PEDDPLLRTG SVFGGLIRDV KRRYPHYPSD
710 720 730 740 750
LRDALHSQCV AAVLFIYFAA LSPAITFGGL LGEKTEGLMG VSELIVSTAV
760 770 780 790 800
LGVLFSLLGA QPLLVVGFSG PLLVFEGAFF KFCQAQDLEY LTGRVWVGLW
810 820 830 840 850
LVVFVLALVG AEGTFLVRYI SPFTQEIFAF LISLIFIYET FHKLYKVFTE
860 870 880 890 900
HPLLPFYPRE GALEGAPEAR LELNGSAPPP TEGPPGPRNQ PNTALLSLIL
910 920 930 940 950
MLGTFLIAFF LRKFRNSRFL GGKARRIIGD FGIPISILLM VLVDYSITDT
960 970 980 990 1000
YTQKLTVPTG LSVTSPHKRT WFIPPLGSAR PFPPWMMVAA AVPALLVLIL
1010 1020 1030 1040 1050
IFMETQITAL IVSQKARRLL KGSGFHLDLL LIGSLGGLCG LFGLPWLTAA
1060 1070 1080 1090 1100
TVRSVTHVNA LTVMRTAIAP GDKPQIQEVR EQRVTGVLIA SLVGLSIVMG
1110 1120 1130 1140 1150
AVLRRIPLAV LFGIFLYMGV TSLSGIQLSQ RLLLILMPAK HHPEQPYVTK
1160 1170 1180 1190 1200
VKTWRMHLFT CIQLACIALL WVVKSTAASL AFPFLLLLTV PLRRCLLPRL
1210 1220 1230
FQDRELQALD SEDAEPNFDE DGQDEYNELH MPV
Length:1,233
Mass (Da):135,760
Last modified:January 1, 1998 - v1
Checksum:iAE486423E9818583
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031650 mRNA. Translation: AAB86859.1.
RefSeqiNP_001075499.1. NM_001082030.1.
UniGeneiOcu.2183.

Genome annotation databases

GeneIDi100008675.
KEGGiocu:100008675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031650 mRNA. Translation: AAB86859.1.
RefSeqiNP_001075499.1. NM_001082030.1.
UniGeneiOcu.2183.

3D structure databases

ProteinModelPortaliO18917.
SMRiO18917. Positions 693-734.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008675.
KEGGiocu:100008675.

Organism-specific databases

CTDi6508.

Phylogenomic databases

eggNOGiNOG268067.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiO18917.
KOiK13856.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Abuladze N., Pushkin A., Kurtz I.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiB3A3_RABIT
AccessioniPrimary (citable) accession number: O18917
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: February 4, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.