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O18917

- B3A3_RABIT

UniProt

O18917 - B3A3_RABIT

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Protein

Anion exchange protein 3

Gene
SLC4A3, AE3
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plasma membrane anion exchange protein.

GO - Molecular functioni

  1. inorganic anion exchanger activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 3
Short name:
AE 3
Short name:
Anion exchanger 3
Alternative name(s):
Anion exchanger 3 brain isoform
Neuronal band 3-like protein
Solute carrier family 4 member 3
Gene namesi
Name:SLC4A3
Synonyms:AE3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 709709CytoplasmicAdd
BLAST
Transmembranei710 – 73223Helical; Reviewed predictionAdd
BLAST
Transmembranei738 – 77538Helical; Reviewed predictionAdd
BLAST
Transmembranei795 – 81723Helical; Reviewed predictionAdd
BLAST
Transmembranei827 – 84822Helical; Reviewed predictionAdd
BLAST
Transmembranei894 – 91118Helical; Reviewed predictionAdd
BLAST
Topological domaini912 – 92615Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei927 – 94721Helical; Reviewed predictionAdd
BLAST
Transmembranei981 – 100323Helical; Reviewed predictionAdd
BLAST
Transmembranei1029 – 105022Helical; Reviewed predictionAdd
BLAST
Transmembranei1084 – 112946Helical; Reviewed predictionAdd
BLAST
Transmembranei1156 – 119237Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12331233Anion exchange protein 3PRO_0000079221Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi874 – 8741N-linked (GlcNAc...) Reviewed prediction
Lipidationi1166 – 11661S-palmitoyl cysteine By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Expressioni

Tissue specificityi

Neuronal.

Structurei

3D structure databases

ProteinModelPortaliO18917.
SMRiO18917. Positions 693-734.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni710 – 1233524Membrane (anion exchange)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi74 – 8310His-rich
Compositional biasi136 – 15015Poly-GluAdd
BLAST
Compositional biasi203 – 2086Poly-Ser
Compositional biasi309 – 3124Poly-Lys
Compositional biasi443 – 4464Poly-Ser
Compositional biasi1185 – 11884Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268067.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18917-1 [UniParc]FASTAAdd to Basket

« Hide

MANGVIPPPG GASPLPQVRV PLEEPPLSPD TEEEDDDLGK TLAVSRFGDL     50
ISKPPAWDPE KPSRSFSERD FAFHRHISHH THHPLSARLP PPHKLRRLPP 100
TFARHTRRKR KKEKTSAPPS EGTPPIQEEG GAGAHEGEEE EEEEEEGESE 150
TEAVEPPPSG SPQKAKFSIG SDEDDSPGLP GKAAFTKPLP SVGPRSDKSP 200
QRSVSSSSPR ARAPRVAGER SRPWSPSASY DLRERLCPGS ALGNPGGPEQ 250
QVPTDEAEAQ MLGSADLDDM KSHRLEDNPG VRRHLVKEPS RVQGGRGSRG 300
GLTPTLRRKK KKQQPDRRPH EVFVELNELM LDRSQEPHWR ETARWIKFEE 350
DVEEETERWG KPHVASLSFR SLLELRRTIA HGAALLDLEQ TTLPGIAHLV 400
VETMIVSDQI RPEDRASVLR TLLLKHCHPN DDKDCGSFPR NPSSSSVNSV 450
LGNHHATPSH GPDGAVPTMA DDLGEPAPLW PHDPDAKERP LHMPGGDGHR 500
GKSLKLLEKI PEDAEATVVL VGCVPFLEQP AAAFVRLSEA VLLESVLEVP 550
VPVRFLFVML GPSHISTDYH ELGRSIATLM SDKLFHEAAY QADDRQDLLG 600
AISEFLDGSI VIPPSEVEGR DLLRSVAAFQ RELLRKRRER EQTKVEMTTR 650
GGYLAPGKEL ALELGGSDAA PEDDPLLRTG SVFGGLIRDV KRRYPHYPSD 700
LRDALHSQCV AAVLFIYFAA LSPAITFGGL LGEKTEGLMG VSELIVSTAV 750
LGVLFSLLGA QPLLVVGFSG PLLVFEGAFF KFCQAQDLEY LTGRVWVGLW 800
LVVFVLALVG AEGTFLVRYI SPFTQEIFAF LISLIFIYET FHKLYKVFTE 850
HPLLPFYPRE GALEGAPEAR LELNGSAPPP TEGPPGPRNQ PNTALLSLIL 900
MLGTFLIAFF LRKFRNSRFL GGKARRIIGD FGIPISILLM VLVDYSITDT 950
YTQKLTVPTG LSVTSPHKRT WFIPPLGSAR PFPPWMMVAA AVPALLVLIL 1000
IFMETQITAL IVSQKARRLL KGSGFHLDLL LIGSLGGLCG LFGLPWLTAA 1050
TVRSVTHVNA LTVMRTAIAP GDKPQIQEVR EQRVTGVLIA SLVGLSIVMG 1100
AVLRRIPLAV LFGIFLYMGV TSLSGIQLSQ RLLLILMPAK HHPEQPYVTK 1150
VKTWRMHLFT CIQLACIALL WVVKSTAASL AFPFLLLLTV PLRRCLLPRL 1200
FQDRELQALD SEDAEPNFDE DGQDEYNELH MPV 1233
Length:1,233
Mass (Da):135,760
Last modified:January 1, 1998 - v1
Checksum:iAE486423E9818583
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031650 mRNA. Translation: AAB86859.1.
RefSeqiNP_001075499.1. NM_001082030.1.
UniGeneiOcu.2183.

Genome annotation databases

GeneIDi100008675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031650 mRNA. Translation: AAB86859.1 .
RefSeqi NP_001075499.1. NM_001082030.1.
UniGenei Ocu.2183.

3D structure databases

ProteinModelPortali O18917.
SMRi O18917. Positions 693-734.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100008675.

Organism-specific databases

CTDi 6508.

Phylogenomic databases

eggNOGi NOG268067.
HOGENOMi HOG000280683.
HOVERGENi HBG004326.

Family and domain databases

Gene3Di 3.40.1100.10. 1 hit.
InterProi IPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
Pfami PF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view ]
PRINTSi PR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMi SSF55804. SSF55804. 2 hits.
TIGRFAMsi TIGR00834. ae. 1 hit.
PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Abuladze N., Pushkin A., Kurtz I.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiB3A3_RABIT
AccessioniPrimary (citable) accession number: O18917
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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