Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O18917

- B3A3_RABIT

UniProt

O18917 - B3A3_RABIT

Protein

Anion exchange protein 3

Gene

SLC4A3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plasma membrane anion exchange protein.

    GO - Molecular functioni

    1. inorganic anion exchanger activity Source: InterPro

    Keywords - Biological processi

    Anion exchange, Antiport, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anion exchange protein 3
    Short name:
    AE 3
    Short name:
    Anion exchanger 3
    Alternative name(s):
    Anion exchanger 3 brain isoform
    Neuronal band 3-like protein
    Solute carrier family 4 member 3
    Gene namesi
    Name:SLC4A3
    Synonyms:AE3
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12331233Anion exchange protein 3PRO_0000079221Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi874 – 8741N-linked (GlcNAc...)Sequence Analysis
    Lipidationi1166 – 11661S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Expressioni

    Tissue specificityi

    Neuronal.

    Structurei

    3D structure databases

    ProteinModelPortaliO18917.
    SMRiO18917. Positions 693-734.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 709709CytoplasmicAdd
    BLAST
    Topological domaini912 – 92615CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei710 – 73223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei738 – 77538HelicalSequence AnalysisAdd
    BLAST
    Transmembranei795 – 81723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei827 – 84822HelicalSequence AnalysisAdd
    BLAST
    Transmembranei894 – 91118HelicalSequence AnalysisAdd
    BLAST
    Transmembranei927 – 94721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei981 – 100323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1029 – 105022HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1084 – 112946HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1156 – 119237HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni710 – 1233524Membrane (anion exchange)Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi74 – 8310His-rich
    Compositional biasi136 – 15015Poly-GluAdd
    BLAST
    Compositional biasi203 – 2086Poly-Ser
    Compositional biasi309 – 3124Poly-Lys
    Compositional biasi443 – 4464Poly-Ser
    Compositional biasi1185 – 11884Poly-Leu

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG268067.
    HOGENOMiHOG000280683.
    HOVERGENiHBG004326.

    Family and domain databases

    Gene3Di3.40.1100.10. 1 hit.
    InterProiIPR001717. Anion_exchange.
    IPR002979. Anion_exchange_3.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF15. PTHR11453:SF15. 1 hit.
    PfamiPF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view]
    PRINTSiPR00165. ANIONEXCHNGR.
    PR01189. ANIONEXHNGR3.
    PR01231. HCO3TRNSPORT.
    SUPFAMiSSF55804. SSF55804. 2 hits.
    TIGRFAMsiTIGR00834. ae. 1 hit.
    PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O18917-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANGVIPPPG GASPLPQVRV PLEEPPLSPD TEEEDDDLGK TLAVSRFGDL     50
    ISKPPAWDPE KPSRSFSERD FAFHRHISHH THHPLSARLP PPHKLRRLPP 100
    TFARHTRRKR KKEKTSAPPS EGTPPIQEEG GAGAHEGEEE EEEEEEGESE 150
    TEAVEPPPSG SPQKAKFSIG SDEDDSPGLP GKAAFTKPLP SVGPRSDKSP 200
    QRSVSSSSPR ARAPRVAGER SRPWSPSASY DLRERLCPGS ALGNPGGPEQ 250
    QVPTDEAEAQ MLGSADLDDM KSHRLEDNPG VRRHLVKEPS RVQGGRGSRG 300
    GLTPTLRRKK KKQQPDRRPH EVFVELNELM LDRSQEPHWR ETARWIKFEE 350
    DVEEETERWG KPHVASLSFR SLLELRRTIA HGAALLDLEQ TTLPGIAHLV 400
    VETMIVSDQI RPEDRASVLR TLLLKHCHPN DDKDCGSFPR NPSSSSVNSV 450
    LGNHHATPSH GPDGAVPTMA DDLGEPAPLW PHDPDAKERP LHMPGGDGHR 500
    GKSLKLLEKI PEDAEATVVL VGCVPFLEQP AAAFVRLSEA VLLESVLEVP 550
    VPVRFLFVML GPSHISTDYH ELGRSIATLM SDKLFHEAAY QADDRQDLLG 600
    AISEFLDGSI VIPPSEVEGR DLLRSVAAFQ RELLRKRRER EQTKVEMTTR 650
    GGYLAPGKEL ALELGGSDAA PEDDPLLRTG SVFGGLIRDV KRRYPHYPSD 700
    LRDALHSQCV AAVLFIYFAA LSPAITFGGL LGEKTEGLMG VSELIVSTAV 750
    LGVLFSLLGA QPLLVVGFSG PLLVFEGAFF KFCQAQDLEY LTGRVWVGLW 800
    LVVFVLALVG AEGTFLVRYI SPFTQEIFAF LISLIFIYET FHKLYKVFTE 850
    HPLLPFYPRE GALEGAPEAR LELNGSAPPP TEGPPGPRNQ PNTALLSLIL 900
    MLGTFLIAFF LRKFRNSRFL GGKARRIIGD FGIPISILLM VLVDYSITDT 950
    YTQKLTVPTG LSVTSPHKRT WFIPPLGSAR PFPPWMMVAA AVPALLVLIL 1000
    IFMETQITAL IVSQKARRLL KGSGFHLDLL LIGSLGGLCG LFGLPWLTAA 1050
    TVRSVTHVNA LTVMRTAIAP GDKPQIQEVR EQRVTGVLIA SLVGLSIVMG 1100
    AVLRRIPLAV LFGIFLYMGV TSLSGIQLSQ RLLLILMPAK HHPEQPYVTK 1150
    VKTWRMHLFT CIQLACIALL WVVKSTAASL AFPFLLLLTV PLRRCLLPRL 1200
    FQDRELQALD SEDAEPNFDE DGQDEYNELH MPV 1233
    Length:1,233
    Mass (Da):135,760
    Last modified:January 1, 1998 - v1
    Checksum:iAE486423E9818583
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031650 mRNA. Translation: AAB86859.1.
    RefSeqiNP_001075499.1. NM_001082030.1.
    UniGeneiOcu.2183.

    Genome annotation databases

    GeneIDi100008675.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031650 mRNA. Translation: AAB86859.1 .
    RefSeqi NP_001075499.1. NM_001082030.1.
    UniGenei Ocu.2183.

    3D structure databases

    ProteinModelPortali O18917.
    SMRi O18917. Positions 693-734.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100008675.

    Organism-specific databases

    CTDi 6508.

    Phylogenomic databases

    eggNOGi NOG268067.
    HOGENOMi HOG000280683.
    HOVERGENi HBG004326.

    Family and domain databases

    Gene3Di 3.40.1100.10. 1 hit.
    InterProi IPR001717. Anion_exchange.
    IPR002979. Anion_exchange_3.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF15. PTHR11453:SF15. 1 hit.
    Pfami PF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view ]
    PRINTSi PR00165. ANIONEXCHNGR.
    PR01189. ANIONEXHNGR3.
    PR01231. HCO3TRNSPORT.
    SUPFAMi SSF55804. SSF55804. 2 hits.
    TIGRFAMsi TIGR00834. ae. 1 hit.
    PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Abuladze N., Pushkin A., Kurtz I.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiB3A3_RABIT
    AccessioniPrimary (citable) accession number: O18917
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3