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O18917 (B3A3_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Anion exchange protein 3
Short name=AE 3
Short name=Anion exchanger 3
Alternative name(s):
Anion exchanger 3 brain isoform
Neuronal band 3-like protein
Solute carrier family 4 member 3
Gene names
Name:SLC4A3
Synonyms:AE3
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length1233 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plasma membrane anion exchange protein.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Neuronal.

Sequence similarities

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Ontologies

Keywords
   Biological processAnion exchange
Antiport
Ion transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
Lipoprotein
Palmitate
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioninorganic anion exchanger activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12331233Anion exchange protein 3
PRO_0000079221

Regions

Topological domain1 – 709709Cytoplasmic
Transmembrane710 – 73223Helical; Potential
Transmembrane738 – 77538Helical; Potential
Transmembrane795 – 81723Helical; Potential
Transmembrane827 – 84822Helical; Potential
Transmembrane894 – 91118Helical; Potential
Topological domain912 – 92615Cytoplasmic Potential
Transmembrane927 – 94721Helical; Potential
Transmembrane981 – 100323Helical; Potential
Transmembrane1029 – 105022Helical; Potential
Transmembrane1084 – 112946Helical; Potential
Transmembrane1156 – 119237Helical; Potential
Region710 – 1233524Membrane (anion exchange)
Compositional bias74 – 8310His-rich
Compositional bias136 – 15015Poly-Glu
Compositional bias203 – 2086Poly-Ser
Compositional bias309 – 3124Poly-Lys
Compositional bias443 – 4464Poly-Ser
Compositional bias1185 – 11884Poly-Leu

Amino acid modifications

Modified residue1711Phosphoserine By similarity
Modified residue1991Phosphoserine By similarity
Modified residue2981Phosphoserine By similarity
Lipidation11661S-palmitoyl cysteine By similarity
Glycosylation8741N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O18917 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: AE486423E9818583

FASTA1,233135,760
        10         20         30         40         50         60 
MANGVIPPPG GASPLPQVRV PLEEPPLSPD TEEEDDDLGK TLAVSRFGDL ISKPPAWDPE 

        70         80         90        100        110        120 
KPSRSFSERD FAFHRHISHH THHPLSARLP PPHKLRRLPP TFARHTRRKR KKEKTSAPPS 

       130        140        150        160        170        180 
EGTPPIQEEG GAGAHEGEEE EEEEEEGESE TEAVEPPPSG SPQKAKFSIG SDEDDSPGLP 

       190        200        210        220        230        240 
GKAAFTKPLP SVGPRSDKSP QRSVSSSSPR ARAPRVAGER SRPWSPSASY DLRERLCPGS 

       250        260        270        280        290        300 
ALGNPGGPEQ QVPTDEAEAQ MLGSADLDDM KSHRLEDNPG VRRHLVKEPS RVQGGRGSRG 

       310        320        330        340        350        360 
GLTPTLRRKK KKQQPDRRPH EVFVELNELM LDRSQEPHWR ETARWIKFEE DVEEETERWG 

       370        380        390        400        410        420 
KPHVASLSFR SLLELRRTIA HGAALLDLEQ TTLPGIAHLV VETMIVSDQI RPEDRASVLR 

       430        440        450        460        470        480 
TLLLKHCHPN DDKDCGSFPR NPSSSSVNSV LGNHHATPSH GPDGAVPTMA DDLGEPAPLW 

       490        500        510        520        530        540 
PHDPDAKERP LHMPGGDGHR GKSLKLLEKI PEDAEATVVL VGCVPFLEQP AAAFVRLSEA 

       550        560        570        580        590        600 
VLLESVLEVP VPVRFLFVML GPSHISTDYH ELGRSIATLM SDKLFHEAAY QADDRQDLLG 

       610        620        630        640        650        660 
AISEFLDGSI VIPPSEVEGR DLLRSVAAFQ RELLRKRRER EQTKVEMTTR GGYLAPGKEL 

       670        680        690        700        710        720 
ALELGGSDAA PEDDPLLRTG SVFGGLIRDV KRRYPHYPSD LRDALHSQCV AAVLFIYFAA 

       730        740        750        760        770        780 
LSPAITFGGL LGEKTEGLMG VSELIVSTAV LGVLFSLLGA QPLLVVGFSG PLLVFEGAFF 

       790        800        810        820        830        840 
KFCQAQDLEY LTGRVWVGLW LVVFVLALVG AEGTFLVRYI SPFTQEIFAF LISLIFIYET 

       850        860        870        880        890        900 
FHKLYKVFTE HPLLPFYPRE GALEGAPEAR LELNGSAPPP TEGPPGPRNQ PNTALLSLIL 

       910        920        930        940        950        960 
MLGTFLIAFF LRKFRNSRFL GGKARRIIGD FGIPISILLM VLVDYSITDT YTQKLTVPTG 

       970        980        990       1000       1010       1020 
LSVTSPHKRT WFIPPLGSAR PFPPWMMVAA AVPALLVLIL IFMETQITAL IVSQKARRLL 

      1030       1040       1050       1060       1070       1080 
KGSGFHLDLL LIGSLGGLCG LFGLPWLTAA TVRSVTHVNA LTVMRTAIAP GDKPQIQEVR 

      1090       1100       1110       1120       1130       1140 
EQRVTGVLIA SLVGLSIVMG AVLRRIPLAV LFGIFLYMGV TSLSGIQLSQ RLLLILMPAK 

      1150       1160       1170       1180       1190       1200 
HHPEQPYVTK VKTWRMHLFT CIQLACIALL WVVKSTAASL AFPFLLLLTV PLRRCLLPRL 

      1210       1220       1230 
FQDRELQALD SEDAEPNFDE DGQDEYNELH MPV

« Hide

References

[1]Abuladze N., Pushkin A., Kurtz I.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF031650 mRNA. Translation: AAB86859.1.
RefSeqNP_001075499.1. NM_001082030.1.
UniGeneOcu.2183.

3D structure databases

ProteinModelPortalO18917.
SMRO18917. Positions 693-734.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100008675.

Organism-specific databases

CTD6508.

Phylogenomic databases

eggNOGNOG268067.
HOGENOMHOG000280683.
HOVERGENHBG004326.
OrthoDBEOG4WDDB2.

Family and domain databases

Gene3D3.40.1100.10. 1 hit.
InterProIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
PfamPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMSSF55804. PTrfase/Anion_transptr. 1 hit.
TIGRFAMsTIGR00834. ae. 1 hit.
PROSITEPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3A3_RABIT
AccessionPrimary (citable) accession number: O18917
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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