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Protein
Submitted name:

K-Cl cotransporter

Gene

SLC12A4

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
K-Cl cotransporterImported
Submitted name:
Solute carrier family 12 (Potassium/chloride transporters), member 4 tv1Imported
Gene namesi
Name:SLC12A4Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei119 – 141HelicalSequence analysisAdd BLAST23
Transmembranei153 – 176HelicalSequence analysisAdd BLAST24
Transmembranei253 – 272HelicalSequence analysisAdd BLAST20
Transmembranei279 – 300HelicalSequence analysisAdd BLAST22
Transmembranei410 – 435HelicalSequence analysisAdd BLAST26
Transmembranei456 – 482HelicalSequence analysisAdd BLAST27
Transmembranei502 – 520HelicalSequence analysisAdd BLAST19
Transmembranei556 – 574HelicalSequence analysisAdd BLAST19
Transmembranei580 – 601HelicalSequence analysisAdd BLAST22
Transmembranei613 – 630HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 300AA_permeaseInterPro annotationAdd BLAST178
Domaini418 – 695AA_permeaseInterPro annotationAdd BLAST278
Domaini709 – 827SLC12InterPro annotationAdd BLAST119
Domaini842 – 1086SLC12InterPro annotationAdd BLAST245

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG052852.
KOiK14427.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR000622. KCC1.
IPR000076. KCL_cotranspt.
IPR018491. SLC12_C.
IPR004842. SLC12A_fam.
[Graphical view]
PANTHERiPTHR11827:SF46. PTHR11827:SF46. 4 hits.
PfamiPF00324. AA_permease. 2 hits.
PF03522. SLC12. 2 hits.
[Graphical view]
PRINTSiPR01081. KCLTRNSPORT.
PR01082. KCLTRNSPORT1.
TIGRFAMsiTIGR00930. 2a30. 1 hit.

Sequencei

Sequence statusi: Complete.

O18887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RADREDSDGH GNQKESSPFL
60 70 80 90 100
CPMEASRGND YCDRNLALFE EELDIRPKVS SLLGKLVSYT NLTQGAKEHE
110 120 130 140 150
EAESGEGTRR RAAKAPSMGT LMGVYLPCLQ NIFGVILFLR LTWMVGTAGV
160 170 180 190 200
LQALLIVLIC CCCTLLTAIS MSAIATNGVV PAGGSYFMIS RSLGPEFGGA
210 220 230 240 250
VGLCFYLGTT FAAAMYILGA IEILLTYIAP PAAIFYPTGT HDTSSATLNN
260 270 280 290 300
MRVYGTIFLT FMTLVVFVGV KYVNKFASLF LACVIISILS IYAGGIKSIF
310 320 330 340 350
DPPVFPVCML GNRTLSRDQF DVCAKTVMVD NETVTTRLWS LFCHSPNLTA
360 370 380 390 400
DSCDPYFLLN NVTEIPGIPG AAASVLQENL WSAYLEKGEV VEKHGLPSTD
410 420 430 440 450
ALGLKESLPL YVVADIATSF TVLVGIFFPS VTGIMAGSNR SGDLRDAQKS
460 470 480 490 500
IPVGTILAII TTSLVYFSSV VLFGACIEGV VLRDKYGDGV SRNLVVGTLA
510 520 530 540 550
WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIAKDNIIP FLRVFGHGKA
560 570 580 590 600
NGEPTWALLL TALIAELGIL IASLDMVAPI LSMFFLMCYL FVNLACAVQT
610 620 630 640 650
LLRTPNWRPR FKYYHWALSF LGMSLCLALM FVSSWYYALV AMLIAGMIYK
660 670 680 690 700
YIEYQGAEKE WGDGIRGLSL SAARYALLRL EEGPPHTKNW RPQLLVLLKL
710 720 730 740 750
DEDLHVKYPR LLTFASQLKA GKGLTIVGSV IQGSFLESYG EAQAAEQTIK
760 770 780 790 800
NMMEIEKVKG FCQVVVASKV REGLAHLIQS CGLGGMRHNS VVLGWPYGWR
810 820 830 840 850
QSEDPRAWKT FIDTVRCTTA AHLALLVPKN IAFYPSNHER YLEGHIDVWW
860 870 880 890 900
IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQMDDNSIQ MKKDLAIFLY
910 920 930 940 950
HLRLEAEVEV VEMPNSDISA YTYERTLMME QRSQMLRQMR LTKTEREREA
960 970 980 990 1000
QLVKDRHSAL RLESLYSDEE DESVAGTDKI QMTWTRDKYM EAEPWDPSHT
1010 1020 1030 1040 1050
PDNFRELVHI KPDQSNVRRM HTAVKLNEVI VTRSHDARLV LLNMPGPPKN
1060 1070 1080
SEGDENYMEF LEVLTEGLER VLLVRGGGRE VITIYS
Length:1,086
Mass (Da):120,788
Last modified:January 1, 1998 - v1
Checksum:iB81A8A22BB9F4325
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028807 mRNA. Translation: AAB84137.1.
GACC01000408 mRNA. Translation: JAA74176.1.
PIRiT14114.
RefSeqiNP_999114.1. NM_213949.2.
UniGeneiSsc.4097.

Genome annotation databases

GeneIDi396992.
KEGGissc:396992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028807 mRNA. Translation: AAB84137.1.
GACC01000408 mRNA. Translation: JAA74176.1.
PIRiT14114.
RefSeqiNP_999114.1. NM_213949.2.
UniGeneiSsc.4097.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396992.
KEGGissc:396992.

Organism-specific databases

CTDi6560.

Phylogenomic databases

HOVERGENiHBG052852.
KOiK14427.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR000622. KCC1.
IPR000076. KCL_cotranspt.
IPR018491. SLC12_C.
IPR004842. SLC12A_fam.
[Graphical view]
PANTHERiPTHR11827:SF46. PTHR11827:SF46. 4 hits.
PfamiPF00324. AA_permease. 2 hits.
PF03522. SLC12. 2 hits.
[Graphical view]
PRINTSiPR01081. KCLTRNSPORT.
PR01082. KCLTRNSPORT1.
TIGRFAMsiTIGR00930. 2a30. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO18887_PIG
AccessioniPrimary (citable) accession number: O18887
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: January 20, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.