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Protein
Submitted name:

Thiazide-sensitive sodium chloride cotransporter

Gene

NCCT

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Thiazide-sensitive sodium chloride cotransporterImported
Gene namesi
Name:NCCTImported
OrganismiOryctolagus cuniculus (Rabbit)Imported
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei167 – 19327HelicalSequence analysisAdd
BLAST
Transmembranei213 – 23725HelicalSequence analysisAdd
BLAST
Transmembranei258 – 27720HelicalSequence analysisAdd
BLAST
Transmembranei283 – 30422HelicalSequence analysisAdd
BLAST
Transmembranei338 – 35619HelicalSequence analysisAdd
BLAST
Transmembranei376 – 39621HelicalSequence analysisAdd
BLAST
Transmembranei451 – 47525HelicalSequence analysisAdd
BLAST
Transmembranei504 – 52320HelicalSequence analysisAdd
BLAST
Transmembranei530 – 55021HelicalSequence analysisAdd
BLAST
Transmembranei570 – 60334HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 11569AA_permease_NInterPro annotationAdd
BLAST
Domaini139 – 644506AA_permeaseInterPro annotationAdd
BLAST
Domaini653 – 788136SLC12InterPro annotationAdd
BLAST
Domaini823 – 1027205SLC12InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG052851.
KOiK14426.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR013612. AA_permease_N.
IPR018491. SLC12_C.
IPR002948. SLC12A3.
IPR004842. SLC12A_fam.
[Graphical view]
PANTHERiPTHR11827:SF9. PTHR11827:SF9. 3 hits.
PfamiPF00324. AA_permease. 1 hit.
PF08403. AA_permease_N. 1 hit.
PF03522. SLC12. 2 hits.
[Graphical view]
PRINTSiPR01230. NACLTRNSPORT.
TIGRFAMsiTIGR00930. 2a30. 1 hit.

Sequencei

Sequence statusi: Complete.

O18886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELPASETP GDPALCSGRF TISTLLVGDE PPPSAAYDGS HASHVTLGSS
60 70 80 90 100
LYMRTFGYNT IDVVPAYEHY ANSTLPGEPR KLRPTLADLH SFLKEGSPLH
110 120 130 140 150
VLALDSRPSH EMTDGLVEDE AGAGGEKPGE PVRFGWVKGV MIRCMLNIWG
160 170 180 190 200
VILYLRLPWI TAQAGIVLTW VIILLSVLVT SITGLSISAI STNGKVKSGG
210 220 230 240 250
TYFLISRSLG PELGGSIGLI FSFANAVGVA MHTVGFAETV RDLLQEYGTP
260 270 280 290 300
IVDPINDIRI IGVVTVTVLL AISLAGMEWE SKAQVLFFLV IMVSFTNYLV
310 320 330 340 350
GTLIPPSEDK ASKGFFSYRG DIFVQNLVPD WRGVDGSFFG MFSIFFPSAT
360 370 380 390 400
GILAGANISG DLKDPAVAIP KGTLMAIFWT TVSYLAISAT IGACVVRDAS
410 420 430 440 450
GNLNDTVTPG LGACEGLACG YGWNFTECAQ RHSCRYGLIN YYQTMSMVSG
460 470 480 490 500
FAPLITAGIF GATLSSALAC LVSAAKVFQC LCEDQLYPLI GFFGKGYGKN
510 520 530 540 550
NEPVRGYLLA YAIAVAFIII AELNTIAPII SNFFLCSYAL INFSCFHASI
560 570 580 590 600
TNSPGWRPSF RYYSKWSALF GAVVSVVIMF LLTWWAALIA IGVILFLLLY
610 620 630 640 650
VIYKKPEVNW GSSVQAGSYN LALSYAVGLN EVEDHIKNYR PQCLVLTGPP
660 670 680 690 700
NFRPALVDFV GTFTQNLSLM ICGHVLIGPR KQRMPELRLI ASGHTKWLNK
710 720 730 740 750
RKIKAFYSDV AAEDLRSGVQ SLMQASGLGR MKPNILVVGF KKNWQAAHPA
760 770 780 790 800
TVEDYIGILH DAFDLSYGVC VMRMREGLNV SEVMQAHINP TFDPAEDGKA
810 820 830 840 850
ASTGGARPAV SGAAEPETLA REEQASTVFQ LEQGKKTIDI YWLFDDGGLT
860 870 880 890 900
LLIPYLLGRK KRWSRCKIRV FVGGQINRMD QERKAMVSLL SKFRLGFHEV
910 920 930 940 950
HVLPDINQKP RAEHTKRFED MIAPFRLNDG FKDEATVAEM RRDCPWKISD
960 970 980 990 1000
EEINKNRIKS LRQVRLNEIL LDYSRDAALV VITLPIGRKG KCPSSLYMAW
1010 1020
LETLSQDLRP PVILIRGNQE NVLTFYCQ
Length:1,028
Mass (Da):112,782
Last modified:January 1, 1998 - v1
Checksum:iFEC6C84B94411A5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028241 mRNA. Translation: AAC33139.1.
RefSeqiNP_001076118.1. NM_001082649.1.
UniGeneiOcu.2215.

Genome annotation databases

GeneIDi100009348.
KEGGiocu:100009348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028241 mRNA. Translation: AAC33139.1.
RefSeqiNP_001076118.1. NM_001082649.1.
UniGeneiOcu.2215.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009348.
KEGGiocu:100009348.

Organism-specific databases

CTDi6559.

Phylogenomic databases

HOVERGENiHBG052851.
KOiK14426.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR013612. AA_permease_N.
IPR018491. SLC12_C.
IPR002948. SLC12A3.
IPR004842. SLC12A_fam.
[Graphical view]
PANTHERiPTHR11827:SF9. PTHR11827:SF9. 3 hits.
PfamiPF00324. AA_permease. 1 hit.
PF08403. AA_permease_N. 1 hit.
PF03522. SLC12. 2 hits.
[Graphical view]
PRINTSiPR01230. NACLTRNSPORT.
TIGRFAMsiTIGR00930. 2a30. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Rabbit distal convoluted tubule coexpresses NaCl cotransporter and 11 beta-hydroxysteroid dehydrogenase II mRNA."
    Velazquez H., Naray-Fejes-Toth A., Silva T., Andujar E., Reilly R.F., Desir G.V., Ellison D.H.
    Kidney Int. 54:464-472(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO18886_RABIT
AccessioniPrimary (citable) accession number: O18886
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: December 9, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.