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O18879

- GSTA2_BOVIN

UniProt

O18879 - GSTA2_BOVIN

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Protein
Glutathione S-transferase A2
Gene
GSTA2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Glutathione By similarity
Binding sitei45 – 451Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A2 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha member 2
Glutathione S-transferase alpha-2
Gene namesi
Name:GSTA2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 23

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 223222Glutathione S-transferase A2
PRO_0000185781Add
BLAST

Proteomic databases

PaxDbiO18879.
PRIDEiO18879.

Expressioni

Tissue specificityi

Expressed in corpus luteum, adrenal gland, testis, liver, lung, thyroid and kidney.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043661.

Structurei

3D structure databases

ProteinModelPortaliO18879.
SMRiO18879. Positions 2-221.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8381GST N-terminal
Add
BLAST
Domaini85 – 208124GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 552Glutathione binding By similarity
Regioni67 – 682Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.

Phylogenomic databases

eggNOGiNOG266414.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiO18879.
KOiK00799.
OMAiNIRGRME.
OrthoDBiEOG79CZ0K.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O18879-1 [UniParc]FASTAAdd to Basket

« Hide

MAGKPKLHYF NGRGRMECIR WLLAAAGVEF EEKFIEQPED LDKLRNDGSL    50
MFQQVPMVEI DGMKLVQTRA ILNYIATKYN LYGKDMKERA LIDMYSEGVE 100
DLGEMIMHLP LCPPDQKDAK IAQIKERTTN RYFPAFEKVL KNHGQDYLVG 150
NKLSKADIHL VELLYYVEEL DPSLLANFPL LKGLKARVSS LPAVKKFLQP 200
GSQRKPPMDE KNLEEAKRIF RIK 223
Length:223
Mass (Da):25,717
Last modified:January 23, 2007 - v4
Checksum:iD61050D129901EB7
GO

Sequence cautioni

The sequence AAB83995.1 differs from that shown. Reason: Frameshift at positions 64 and 80.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027386 mRNA. Translation: AAB83995.1. Frameshift.
BC114835 mRNA. Translation: AAI14836.1.
RefSeqiNP_803481.1. NM_177515.2.
UniGeneiBt.62641.

Genome annotation databases

EnsembliENSBTAT00000046354; ENSBTAP00000043661; ENSBTAG00000006546.
GeneIDi281805.
KEGGibta:281805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027386 mRNA. Translation: AAB83995.1 . Frameshift.
BC114835 mRNA. Translation: AAI14836.1 .
RefSeqi NP_803481.1. NM_177515.2.
UniGenei Bt.62641.

3D structure databases

ProteinModelPortali O18879.
SMRi O18879. Positions 2-221.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000043661.

Proteomic databases

PaxDbi O18879.
PRIDEi O18879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000046354 ; ENSBTAP00000043661 ; ENSBTAG00000006546 .
GeneIDi 281805.
KEGGi bta:281805.

Organism-specific databases

CTDi 2939.

Phylogenomic databases

eggNOGi NOG266414.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115734.
HOVERGENi HBG053749.
InParanoidi O18879.
KOi K00799.
OMAi NIRGRME.
OrthoDBi EOG79CZ0K.
TreeFami TF105321.

Miscellaneous databases

NextBioi 20805718.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01266. GSTRNSFRASEA.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High expression of bovine alpha glutathione S-transferase (GSTA1, GSTA2) subunits is mainly associated with steroidogenically active cells and regulated by gonadotropins in bovine ovarian follicles."
    Rabahi F., Brule S., Sirois J., Beckers J.-F.M.P., Silversides D.W., Lussier J.G.
    Endocrinology 140:3507-3517(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Holstein.
    Tissue: Corpus luteum.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiGSTA2_BOVIN
AccessioniPrimary (citable) accession number: O18879
Secondary accession number(s): Q1RML3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 100 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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