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Protein

Minor allergen Can f 2

Gene
N/A
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Minor allergen Can f 2
Alternative name(s):
Allergen Dog 2
Allergen: Can f 2
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei175 Can f 2
3170 Can f 2.0101

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001798119 – 180Minor allergen Can f 2Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi82 ↔ 1751 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO18874

Expressioni

Tissue specificityi

Tongue epithelial tissue and parotid gland.

Gene expression databases

BgeeiENSCAFG00000019749

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 33Combined sources4
Beta strandi38 – 46Combined sources9
Helixi47 – 49Combined sources3
Beta strandi59 – 66Combined sources8
Beta strandi69 – 77Combined sources9
Beta strandi79 – 91Combined sources13
Beta strandi97 – 114Combined sources18
Turni115 – 117Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi130 – 140Combined sources11
Helixi142 – 144Combined sources3
Turni145 – 148Combined sources4
Helixi149 – 158Combined sources10
Helixi163 – 165Combined sources3
Beta strandi166 – 168Combined sources3
Turni171 – 173Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L4RX-ray1.45A20-180[»]
ProteinModelPortaliO18874
SMRiO18874
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO18874

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEEW Eukaryota
ENOG411154J LUCA
GeneTreeiENSGT00530000063356
HOGENOMiHOG000202729
InParanoidiO18874
OMAiCENAAIS
OrthoDBiEOG091G10G9
TreeFamiTF338197

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002971 Maj_urinary
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01221 MAJORURINARY
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O18874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLLLLTVGL ALICGLQAQE GNHEEPQGGL EELSGRWHSV ALASNKSDLI
60 70 80 90 100
KPWGHFRVFI HSMSAKDGNL HGDILIPQDG QCEKVSLTAF KTATSNKFDL
110 120 130 140 150
EYWGHNDLYL AEVDPKSYLI LYMINQYNDD TSLVAHLMVR DLSRQQDFLP
160 170 180
AFESVCEDIG LHKDQIVVLS DDDRCQGSRD
Length:180
Mass (Da):20,230
Last modified:January 1, 1998 - v1
Checksum:i2DE17BE496248E28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027178 mRNA Translation: AAC48795.1
RefSeqiNP_001003189.1, NM_001003189.2

Genome annotation databases

EnsembliENSCAFT00000031406; ENSCAFP00000029233; ENSCAFG00000019749
GeneIDi403829
KEGGicfa:403829

Entry informationi

Entry nameiALL2_CANLF
AccessioniPrimary (citable) accession number: O18874
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: February 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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