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Protein

Minor allergen Can f 2

Gene
N/A
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Minor allergen Can f 2
Alternative name(s):
Allergen Dog 2
Allergen: Can f 2
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei175. Can f 2.
3170. Can f 2.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001798119 – 180Minor allergen Can f 2Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi82 ↔ 1751 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO18874.

Expressioni

Tissue specificityi

Tongue epithelial tissue and parotid gland.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 33Combined sources4
Beta strandi38 – 46Combined sources9
Helixi47 – 49Combined sources3
Beta strandi59 – 66Combined sources8
Beta strandi69 – 77Combined sources9
Beta strandi79 – 91Combined sources13
Beta strandi97 – 114Combined sources18
Turni115 – 117Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi130 – 140Combined sources11
Helixi142 – 144Combined sources3
Turni145 – 148Combined sources4
Helixi149 – 158Combined sources10
Helixi163 – 165Combined sources3
Beta strandi166 – 168Combined sources3
Turni171 – 173Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L4RX-ray1.45A20-180[»]
ProteinModelPortaliO18874.
SMRiO18874.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO18874.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEEW. Eukaryota.
ENOG411154J. LUCA.
GeneTreeiENSGT00530000063356.
HOGENOMiHOG000202729.
InParanoidiO18874.
OMAiYRKENIL.
OrthoDBiEOG091G10G9.
TreeFamiTF338197.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O18874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLLLLTVGL ALICGLQAQE GNHEEPQGGL EELSGRWHSV ALASNKSDLI
60 70 80 90 100
KPWGHFRVFI HSMSAKDGNL HGDILIPQDG QCEKVSLTAF KTATSNKFDL
110 120 130 140 150
EYWGHNDLYL AEVDPKSYLI LYMINQYNDD TSLVAHLMVR DLSRQQDFLP
160 170 180
AFESVCEDIG LHKDQIVVLS DDDRCQGSRD
Length:180
Mass (Da):20,230
Last modified:January 1, 1998 - v1
Checksum:i2DE17BE496248E28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027178 mRNA. Translation: AAC48795.1.
RefSeqiNP_001003189.1. NM_001003189.2.

Genome annotation databases

EnsembliENSCAFT00000031406; ENSCAFP00000029233; ENSCAFG00000019749.
GeneIDi403829.
KEGGicfa:403829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027178 mRNA. Translation: AAC48795.1.
RefSeqiNP_001003189.1. NM_001003189.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L4RX-ray1.45A20-180[»]
ProteinModelPortaliO18874.
SMRiO18874.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei175. Can f 2.
3170. Can f 2.0101.

Proteomic databases

PaxDbiO18874.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000031406; ENSCAFP00000029233; ENSCAFG00000019749.
GeneIDi403829.
KEGGicfa:403829.

Organism-specific databases

CTDi403829.

Phylogenomic databases

eggNOGiENOG410JEEW. Eukaryota.
ENOG411154J. LUCA.
GeneTreeiENSGT00530000063356.
HOGENOMiHOG000202729.
InParanoidiO18874.
OMAiYRKENIL.
OrthoDBiEOG091G10G9.
TreeFamiTF338197.

Miscellaneous databases

EvolutionaryTraceiO18874.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALL2_CANLF
AccessioniPrimary (citable) accession number: O18874
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.