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O18873

- ALL1_CANFA

UniProt

O18873 - ALL1_CANFA

Protein

Major allergen Can f 1

Gene
N/A
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major allergen Can f 1
    Alternative name(s):
    Allergen Dog 1
    Allergen: Can f 1
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.1 Publication

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei174. Can f 1.
    3169. Can f 1.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 174156Major allergen Can f 1PRO_0000017980Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi78 ↔ 169By similarity
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Tongue epithelial tissue.

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000029242.

    Structurei

    3D structure databases

    ProteinModelPortaliO18873.
    SMRiO18873. Positions 31-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the calycin superfamily. Lipocalin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG29410.
    HOGENOMiHOG000231562.
    HOVERGENiHBG101411.
    InParanoidiO18873.

    Family and domain databases

    Gene3Di2.40.128.20. 1 hit.
    InterProiIPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    IPR002450. von_Ebner_gland.
    [Graphical view]
    PfamiPF00061. Lipocalin. 1 hit.
    [Graphical view]
    PRINTSiPR01175. VNEBNERGLAND.
    SUPFAMiSSF50814. SSF50814. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O18873-1 [UniParc]FASTAAdd to Basket

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    MKTLLLTIGF SLIAILQAQD TPALGKDTVA VSGKWYLKAM TADQEVPEKP    50
    DSVTPMILKA QKGGNLEAKI TMLTNGQCQN ITVVLHKTSE PGKYTAYEGQ 100
    RVVFIQPSPV RDHYILYCEG ELHGRQIRMA KLLGRDPEQS QEALEDFREF 150
    SRAKGLNQEI LELAQSETCS PGGQ 174
    Length:174
    Mass (Da):19,248
    Last modified:January 1, 1998 - v1
    Checksum:i091A3025660806D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027177 mRNA. Translation: AAC48794.1.
    RefSeqiNP_001003190.1. NM_001003190.1.
    UniGeneiCfa.3693.

    Genome annotation databases

    GeneIDi403830.
    KEGGicfa:403830.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027177 mRNA. Translation: AAC48794.1 .
    RefSeqi NP_001003190.1. NM_001003190.1.
    UniGenei Cfa.3693.

    3D structure databases

    ProteinModelPortali O18873.
    SMRi O18873. Positions 31-166.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000029242.

    Protein family/group databases

    Allergomei 174. Can f 1.
    3169. Can f 1.0101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403830.
    KEGGi cfa:403830.

    Organism-specific databases

    CTDi 3933.

    Phylogenomic databases

    eggNOGi NOG29410.
    HOGENOMi HOG000231562.
    HOVERGENi HBG101411.
    InParanoidi O18873.

    Miscellaneous databases

    NextBioi 20817326.

    Family and domain databases

    Gene3Di 2.40.128.20. 1 hit.
    InterProi IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    IPR002450. von_Ebner_gland.
    [Graphical view ]
    Pfami PF00061. Lipocalin. 1 hit.
    [Graphical view ]
    PRINTSi PR01175. VNEBNERGLAND.
    SUPFAMi SSF50814. SSF50814. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The major dog allergens, Can f 1 and Can f 2, are salivary lipocalin proteins: cloning and immunological characterization of the recombinant forms."
      Konieczny A., Morgenstern J.P., Bizinkauskas C.B., Lilley C.H., Brauer A.W., Bond J.F., Aalberse R.C., Wallner B.P., Kasaian M.T.
      Immunology 92:577-586(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.

    Entry informationi

    Entry nameiALL1_CANFA
    AccessioniPrimary (citable) accession number: O18873
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3