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O18873

- ALL1_CANFA

UniProt

O18873 - ALL1_CANFA

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Protein

Major allergen Can f 1

Gene
N/A
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Major allergen Can f 1
Alternative name(s):
Allergen Dog 1
Allergen: Can f 1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei174. Can f 1.
3169. Can f 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 174156Major allergen Can f 1PRO_0000017980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 169 By similarity
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Tongue epithelial tissue.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000029242.

Structurei

3D structure databases

ProteinModelPortaliO18873.
SMRiO18873. Positions 31-166.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG29410.
HOGENOMiHOG000231562.
HOVERGENiHBG101411.
InParanoidiO18873.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002450. von_Ebner_gland.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01175. VNEBNERGLAND.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O18873-1 [UniParc]FASTAAdd to Basket

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MKTLLLTIGF SLIAILQAQD TPALGKDTVA VSGKWYLKAM TADQEVPEKP    50
DSVTPMILKA QKGGNLEAKI TMLTNGQCQN ITVVLHKTSE PGKYTAYEGQ 100
RVVFIQPSPV RDHYILYCEG ELHGRQIRMA KLLGRDPEQS QEALEDFREF 150
SRAKGLNQEI LELAQSETCS PGGQ 174
Length:174
Mass (Da):19,248
Last modified:January 1, 1998 - v1
Checksum:i091A3025660806D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027177 mRNA. Translation: AAC48794.1.
RefSeqiNP_001003190.1. NM_001003190.1.
UniGeneiCfa.3693.

Genome annotation databases

GeneIDi403830.
KEGGicfa:403830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027177 mRNA. Translation: AAC48794.1 .
RefSeqi NP_001003190.1. NM_001003190.1.
UniGenei Cfa.3693.

3D structure databases

ProteinModelPortali O18873.
SMRi O18873. Positions 31-166.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000029242.

Protein family/group databases

Allergomei 174. Can f 1.
3169. Can f 1.0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403830.
KEGGi cfa:403830.

Organism-specific databases

CTDi 3933.

Phylogenomic databases

eggNOGi NOG29410.
HOGENOMi HOG000231562.
HOVERGENi HBG101411.
InParanoidi O18873.

Miscellaneous databases

NextBioi 20817326.

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002450. von_Ebner_gland.
[Graphical view ]
Pfami PF00061. Lipocalin. 1 hit.
[Graphical view ]
PRINTSi PR01175. VNEBNERGLAND.
SUPFAMi SSF50814. SSF50814. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The major dog allergens, Can f 1 and Can f 2, are salivary lipocalin proteins: cloning and immunological characterization of the recombinant forms."
    Konieczny A., Morgenstern J.P., Bizinkauskas C.B., Lilley C.H., Brauer A.W., Bond J.F., Aalberse R.C., Wallner B.P., Kasaian M.T.
    Immunology 92:577-586(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.

Entry informationi

Entry nameiALL1_CANFA
AccessioniPrimary (citable) accession number: O18873
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: March 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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