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O18873

- ALL1_CANFA

UniProt

O18873 - ALL1_CANFA

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Protein

Major allergen Can f 1

Gene
N/A
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Major allergen Can f 1
Alternative name(s):
Allergen Dog 1
Allergen: Can f 1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei174. Can f 1.
3169. Can f 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 174156Major allergen Can f 1PRO_0000017980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 169By similarity
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Tongue epithelial tissue.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000029242.

Structurei

3D structure databases

ProteinModelPortaliO18873.
SMRiO18873. Positions 31-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG29410.
HOGENOMiHOG000231562.
HOVERGENiHBG101411.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002450. von_Ebner_gland.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01175. VNEBNERGLAND.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O18873-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTLLLTIGF SLIAILQAQD TPALGKDTVA VSGKWYLKAM TADQEVPEKP
60 70 80 90 100
DSVTPMILKA QKGGNLEAKI TMLTNGQCQN ITVVLHKTSE PGKYTAYEGQ
110 120 130 140 150
RVVFIQPSPV RDHYILYCEG ELHGRQIRMA KLLGRDPEQS QEALEDFREF
160 170
SRAKGLNQEI LELAQSETCS PGGQ
Length:174
Mass (Da):19,248
Last modified:January 1, 1998 - v1
Checksum:i091A3025660806D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027177 mRNA. Translation: AAC48794.1.
RefSeqiNP_001003190.1. NM_001003190.1.
UniGeneiCfa.3693.

Genome annotation databases

GeneIDi403830.
KEGGicfa:403830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027177 mRNA. Translation: AAC48794.1 .
RefSeqi NP_001003190.1. NM_001003190.1.
UniGenei Cfa.3693.

3D structure databases

ProteinModelPortali O18873.
SMRi O18873. Positions 31-166.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000029242.

Protein family/group databases

Allergomei 174. Can f 1.
3169. Can f 1.0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403830.
KEGGi cfa:403830.

Organism-specific databases

CTDi 3933.

Phylogenomic databases

eggNOGi NOG29410.
HOGENOMi HOG000231562.
HOVERGENi HBG101411.

Miscellaneous databases

NextBioi 20817326.

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002450. von_Ebner_gland.
[Graphical view ]
Pfami PF00061. Lipocalin. 1 hit.
[Graphical view ]
PRINTSi PR01175. VNEBNERGLAND.
SUPFAMi SSF50814. SSF50814. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The major dog allergens, Can f 1 and Can f 2, are salivary lipocalin proteins: cloning and immunological characterization of the recombinant forms."
    Konieczny A., Morgenstern J.P., Bizinkauskas C.B., Lilley C.H., Brauer A.W., Bond J.F., Aalberse R.C., Wallner B.P., Kasaian M.T.
    Immunology 92:577-586(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.

Entry informationi

Entry nameiALL1_CANFA
AccessioniPrimary (citable) accession number: O18873
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3