ID   AOFA_SHEEP              Reviewed;          46 AA.
AC   O18851;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 47.
DE   RecName: Full=Amine oxidase [flavin-containing] A;
DE            EC=1.4.3.4;
DE   AltName: Full=Monoamine oxidase type A;
DE            Short=MAO-A;
DE   Flags: Fragment;
GN   Name=MAOA;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=98251499; PubMed=9589594;
RA   Cambridge L.M., Lumsden J.M., Sadhigi M., Galloway S.M.;
RT   "A ScaI polymorphism at the ovine monoamine oxidase A locus (MAOA).";
RL   Anim. Genet. 28:457-457(1997).
CC   -!- FUNCTION: Catalyzes the oxidative deamination of biogenic and
CC       xenobiotic amines and has important functions in the metabolism of
CC       neuroactive and vasoactive amines in the central nervous system
CC       and peripheral tissues. MAOA preferentially oxidizes biogenic
CC       amines such as 5-hydroxytryptamine (5-HT), norepinephrine and
CC       epinephrine (By similarity).
CC   -!- CATALYTIC ACTIVITY: RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) +
CC       H(2)O(2).
CC   -!- COFACTOR: FAD.
CC   -!- SUBUNIT: Monomer, homo- or heterodimer (containing two subunits of
CC       similar size). Each subunit contains a covalently bound flavin.
CC       Enzymatically active as monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane.
CC   -!- SIMILARITY: Belongs to the flavin monoamine oxidase family.
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DR   EMBL; AF023613; AAC16911.1; -; Genomic_DNA.
DR   HSSP; P27338; 1GOS.
DR   SMR; O18851; 1-46.
DR   HOVERGEN; O18851; -.
DR   BRENDA; 1.4.3.4; 271.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008131; F:amine oxidase activity; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0006584; P:catecholamine metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0042135; P:neurotransmitter catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002937; Amino_oxidase.
DR   Pfam; PF01593; Amino_oxidase; 1.
PE   3: Inferred from homology;
KW   Catecholamine metabolism; FAD; Flavoprotein; Membrane; Mitochondrion;
KW   Mitochondrion outer membrane; Neurotransmitter degradation;
KW   Oxidoreductase; Transmembrane.
FT   CHAIN        <1    >46       Amine oxidase [flavin-containing] A.
FT                                /FTId=PRO_0000099855.
FT   NON_TER       1      1
FT   NON_TER      46     46
SQ   SEQUENCE   46 AA;  5349 MW;  FD06EBDEE44F88BA CRC64;
     YVISAIPPTL TSKIHFRPEL PSERNQLIQR LPMGAIIKCM MYYKEA
//