Reviewed,
UniProtKB/Swiss-Prot O18851 (AOFA_SHEEP)
Last modified
November 24, 2009.
Version 48.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (1) |
 Third-party data |
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Names and origin
| Protein names | Recommended name: Amine oxidase [flavin-containing] A EC=1.4.3.4 Alternative name(s): Monoamine oxidase type A Short name=MAO-A | ||
| Gene names |
| ||
| Organism | Ovis aries (Sheep) | ||
| Taxonomic identifier | 9940 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis |
Protein attributes
| Sequence length | 46 AA. |
| Sequence status | Fragment. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity. |
| Catalytic activity | RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2. |
| Cofactor | FAD. |
| Subunit structure | Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the flavin monoamine oxidase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Catecholamine metabolism Neurotransmitter degradation |
| Cellular component | Membrane Mitochondrion Mitochondrion outer membrane |
| Domain | Transmembrane |
| Ligand | FAD Flavoprotein |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | catecholamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW neurotransmitter catabolic processInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | amine oxidase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| [1] | "A ScaI polymorphism at the ovine monoamine oxidase A locus (MAOA)." Cambridge L.M., Lumsden J.M., Sadhigi M., Galloway S.M. Anim. Genet. 28:457-457(1997) [PubMed: 9589594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF023613 Genomic DNA. Translation: AAC16911.1. |
3D structure databases | |
| SMR | O18851. Positions 1-46. |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | O18851. |
Enzyme and pathway databases | |
| BRENDA | 1.4.3.4. 271. |
Family and domain databases | |
| InterPro | IPR002937. Amino_oxidase. [Graphical view] |
| Pfam | PF01593. Amino_oxidase. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AOFA_SHEEP | ||||||||
| Accession | Primary (citable) accession number: O18851 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
