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O18842

- MT_BALMY

UniProt

O18842 - MT_BALMY

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Protein

Metallothionein

Gene
N/A
Organism
Balaena mysticetus (Bowhead whale)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Divalent metal cation; cluster BBy similarity
Metal bindingi7 – 71Divalent metal cation; cluster BBy similarity
Metal bindingi13 – 131Divalent metal cation; cluster BBy similarity
Metal bindingi15 – 151Divalent metal cation; cluster BBy similarity
Metal bindingi19 – 191Divalent metal cation; cluster BBy similarity
Metal bindingi21 – 211Divalent metal cation; cluster BBy similarity
Metal bindingi24 – 241Divalent metal cation; cluster BBy similarity
Metal bindingi26 – 261Divalent metal cation; cluster BBy similarity
Metal bindingi29 – 291Divalent metal cation; cluster BBy similarity
Metal bindingi33 – 331Divalent metal cation; cluster ABy similarity
Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
Metal bindingi36 – 361Divalent metal cation; cluster ABy similarity
Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
Metal bindingi41 – 411Divalent metal cation; cluster ABy similarity
Metal bindingi44 – 441Divalent metal cation; cluster ABy similarity
Metal bindingi48 – 481Divalent metal cation; cluster ABy similarity
Metal bindingi50 – 501Divalent metal cation; cluster ABy similarity
Metal bindingi57 – 571Divalent metal cation; cluster ABy similarity
Metal bindingi59 – 591Divalent metal cation; cluster ABy similarity
Metal bindingi60 – 601Divalent metal cation; cluster ABy similarity

GO - Molecular functioni

  1. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cellular response to zinc ion Source: UniProtKB
  2. negative regulation of growth Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein
Short name:
MT
OrganismiBalaena mysticetus (Bowhead whale)
Taxonomic identifieri27602 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaMysticetiBalaenidaeBalaena

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6161MetallothioneinPRO_0000197257Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO18842.
SMRiO18842. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929BetaAdd
BLAST
Regioni30 – 6132AlphaAdd
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG009063.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18842-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPNCSCAAG GSCTCAGSCK CKECKCTSCK KSCCSCCPPG CTKCAQGCVC
60
KGASDKCNCC A
Length:61
Mass (Da):6,025
Last modified:January 1, 1998 - v1
Checksum:i4D0A7C5E1D23A4A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022117 mRNA. Translation: AAB72006.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022117 mRNA. Translation: AAB72006.1 .

3D structure databases

ProteinModelPortali O18842.
SMRi O18842. Positions 1-61.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG009063.

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00860. MTVERTEBRATE.
SUPFAMi SSF57868. SSF57868. 1 hit.
PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Kaysen J., O'Hara T., Goodwin T., Linnehan R., Hammond T.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiMT_BALMY
AccessioniPrimary (citable) accession number: O18842
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3