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Protein

Scavenger receptor class B member 1

Gene

SCARB1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-BTA-3000471 Scavenging by Class B Receptors
R-BTA-8964011 HDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Scavenger receptor class B member 1
Short name:
SRB1
Alternative name(s):
SR-BI
Gene namesi
Name:SCARB1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Organism-specific databases

VGNCiVGNC:34324 SCARB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 440ExtracellularSequence analysisAdd BLAST408
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 509CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441581 – 509Scavenger receptor class B member 1Add BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi251 ↔ 384By similarity
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity
The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO18824
PRIDEiO18824

Expressioni

Gene expression databases

BgeeiENSBTAG00000014269
ExpressionAtlasiO18824 baseline

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018959

Structurei

3D structure databases

SMRiO18824
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3776 Eukaryota
ENOG410XS17 LUCA
GeneTreeiENSGT00530000062927
HOGENOMiHOG000252951
HOVERGENiHBG106577
InParanoidiO18824
KOiK13885
OMAiSQEKCYL
OrthoDBiEOG091G0CH9
TreeFamiTF317925

Family and domain databases

InterProiView protein in InterPro
IPR002159 CD36_fam
PANTHERiPTHR11923 PTHR11923, 1 hit
PfamiView protein in Pfam
PF01130 CD36, 1 hit
PRINTSiPR01609 CD36FAMILY

Sequencei

Sequence statusi: Complete.

O18824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNLSRARRV TAALGFIGLL FAVLGIIMIV MVPSIIKQQV LKNVRIDPNS
60 70 80 90 100
LSFNMWKEIP VPFYLSVYFF NIVNPEGIIQ GQKPQVQEHG PYVYREFRHK
110 120 130 140 150
SNITFNNNDT VSFLEYRSYQ FQPDKSRGQE SDYIVMPNIL VLSASMMMEN
160 170 180 190 200
RPGLLKLMMT LAFSTLGQRA FMNRTVGEIM WGYDDPLIHL INQYFPNSLP
210 220 230 240 250
FKGKFGLFAE LNNSDSGLFT VFTGVKNFSR IHLVDKWNGV SKVNYWHSDQ
260 270 280 290 300
CNMINGTSGQ MWAPFMTPES SLEFYSPEAC RSMKLVYKEQ GVFGGIPTFR
310 320 330 340 350
FVAPSTLFAN GSVYPPNEGF CPCRESGIQN VSTCRFNAPL FLSHPHFYNA
360 370 380 390 400
DPVLAEAVSG LHPNPKEHSL FLDIHPVTGI PMNCSVKLQL SLFVKSVKGI
410 420 430 440 450
GQTGNIQPVV LPLMWFEESG AMEGETLETF YIQLVLMPKV LHYAQYVLLA
460 470 480 490 500
LGCVLLLIPI IYQIRSQEKC YLFWISFKKG SKDKEAVQAY SEFLMTSAPK

GTVLQEARL
Length:509
Mass (Da):57,610
Last modified:January 1, 1998 - v1
Checksum:iB3B7FD368C22C12F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019384 mRNA Translation: AAB70920.1
RefSeqiNP_777022.1, NM_174597.2
UniGeneiBt.4520

Genome annotation databases

EnsembliENSBTAT00000018959; ENSBTAP00000018959; ENSBTAG00000014269
GeneIDi282346
KEGGibta:282346

Similar proteinsi

Entry informationi

Entry nameiSCRB1_BOVIN
AccessioniPrimary (citable) accession number: O18824
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health