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Protein

Scavenger receptor class B member 1

Gene

SCARB1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (By similarity). Plays an important role in the uptake of HDL cholesteryl ester (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-BTA-194223. HDL-mediated lipid transport.
R-BTA-3000471. Scavenging by Class B Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Scavenger receptor class B member 1
Short name:
SRB1
Alternative name(s):
SR-BI
Gene namesi
Name:SCARB1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 440ExtracellularSequence analysisAdd BLAST408
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 509CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441581 – 509Scavenger receptor class B member 1Add BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Glycosylationi212N-linked (GlcNAc...)Sequence analysis1
Glycosylationi227N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi251 ↔ 384By similarity
Glycosylationi255N-linked (GlcNAc...)Sequence analysis1
Glycosylationi310N-linked (GlcNAc...)Sequence analysis1
Glycosylationi330N-linked (GlcNAc...)Sequence analysis1
Glycosylationi383N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity
The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO18824.
PRIDEiO18824.

Expressioni

Gene expression databases

BgeeiENSBTAG00000014269.
ExpressionAtlasiO18824. differential.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018959.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
GeneTreeiENSGT00530000062927.
HOGENOMiHOG000252951.
HOVERGENiHBG106577.
InParanoidiO18824.
KOiK13885.
OMAiMWKEIPI.
OrthoDBiEOG091G0CH9.
TreeFamiTF317925.

Family and domain databases

InterProiIPR002159. CD36_fam.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01609. CD36FAMILY.

Sequencei

Sequence statusi: Complete.

O18824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNLSRARRV TAALGFIGLL FAVLGIIMIV MVPSIIKQQV LKNVRIDPNS
60 70 80 90 100
LSFNMWKEIP VPFYLSVYFF NIVNPEGIIQ GQKPQVQEHG PYVYREFRHK
110 120 130 140 150
SNITFNNNDT VSFLEYRSYQ FQPDKSRGQE SDYIVMPNIL VLSASMMMEN
160 170 180 190 200
RPGLLKLMMT LAFSTLGQRA FMNRTVGEIM WGYDDPLIHL INQYFPNSLP
210 220 230 240 250
FKGKFGLFAE LNNSDSGLFT VFTGVKNFSR IHLVDKWNGV SKVNYWHSDQ
260 270 280 290 300
CNMINGTSGQ MWAPFMTPES SLEFYSPEAC RSMKLVYKEQ GVFGGIPTFR
310 320 330 340 350
FVAPSTLFAN GSVYPPNEGF CPCRESGIQN VSTCRFNAPL FLSHPHFYNA
360 370 380 390 400
DPVLAEAVSG LHPNPKEHSL FLDIHPVTGI PMNCSVKLQL SLFVKSVKGI
410 420 430 440 450
GQTGNIQPVV LPLMWFEESG AMEGETLETF YIQLVLMPKV LHYAQYVLLA
460 470 480 490 500
LGCVLLLIPI IYQIRSQEKC YLFWISFKKG SKDKEAVQAY SEFLMTSAPK

GTVLQEARL
Length:509
Mass (Da):57,610
Last modified:January 1, 1998 - v1
Checksum:iB3B7FD368C22C12F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019384 mRNA. Translation: AAB70920.1.
RefSeqiNP_777022.1. NM_174597.2.
UniGeneiBt.4520.

Genome annotation databases

EnsembliENSBTAT00000018959; ENSBTAP00000018959; ENSBTAG00000014269.
GeneIDi282346.
KEGGibta:282346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019384 mRNA. Translation: AAB70920.1.
RefSeqiNP_777022.1. NM_174597.2.
UniGeneiBt.4520.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018959.

Proteomic databases

PaxDbiO18824.
PRIDEiO18824.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018959; ENSBTAP00000018959; ENSBTAG00000014269.
GeneIDi282346.
KEGGibta:282346.

Organism-specific databases

CTDi949.

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
GeneTreeiENSGT00530000062927.
HOGENOMiHOG000252951.
HOVERGENiHBG106577.
InParanoidiO18824.
KOiK13885.
OMAiMWKEIPI.
OrthoDBiEOG091G0CH9.
TreeFamiTF317925.

Enzyme and pathway databases

ReactomeiR-BTA-194223. HDL-mediated lipid transport.
R-BTA-3000471. Scavenging by Class B Receptors.

Gene expression databases

BgeeiENSBTAG00000014269.
ExpressionAtlasiO18824. differential.

Family and domain databases

InterProiIPR002159. CD36_fam.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01609. CD36FAMILY.
ProtoNetiSearch...

Entry informationi

Entry nameiSCRB1_BOVIN
AccessioniPrimary (citable) accession number: O18824
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.