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O18809

- CP2F3_CAPHI

UniProt

O18809 - CP2F3_CAPHI

Protein

Cytochrome P450 2F3

Gene

CYP2F3

Organism
Capra hircus (Goat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. Stereoselectively catalyzes the formation of the 1R,2S-oxide from naphthalene. Lack activity with other common P450 substrates including 7-ethoxycoumarin.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi436 – 4361Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. oxygen binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2F3 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIF3
    Gene namesi
    Name:CYP2F3
    OrganismiCapra hircus (Goat)
    Taxonomic identifieri9925 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Cytochrome P450 2F3PRO_0000051762Add
    BLAST

    Expressioni

    Tissue specificityi

    Lung specific.

    Structurei

    3D structure databases

    ProteinModelPortaliO18809.
    SMRiO18809. Positions 27-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG015789.
    KOiK07416.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR020469. Cyt_P450_CYP2_fam.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01957. EP450ICYP2F.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O18809-1 [UniParc]FASTAAdd to Basket

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    MDSISTAILL LILALICLLL TTSSKGKGRL PPGPRALPFL GNLLQLRSQD    50
    MLTSLTKLSK EFGAVYTVYL GPRRVVVLSG YQAVKEALVD QAEEFSGRGD 100
    YPAFFNFTKG NGIAFSNGDR WKALRKYSLQ ILRNFGMGKR TIEERILEEG 150
    HFLLEELRKT QGKPFDPTFV VSRSVSNIIC SVIFGSRFDY DDDRLLTIIH 200
    LINENFQIMS SPWGEMYNIF PNLLDWVPGP HRRLFKNYGR MKNLIARSVR 250
    EHQASLDPNS PRDFIDCFLT KMAQEKQDPL SHFFMDTLLM TTHNLLFGGT 300
    ETVGTTLRHA FRLLMKYPEV QVRVQEEIDR VVGRERLPTV EDRAEMPYTD 350
    AVIHEVQRFA DIIPMSLPHR VTRDTNFRGF TIPRGTDVIT LLNTVHYDPS 400
    QFLKPKEFNP EHFLDANMSF KKSPAFMPFS AGRRLCLGEA LARMELFLYL 450
    TAILQSFSLQ PLGAPEDIDL TPLSSGLGNV PRPYQLCVRA R 491
    Length:491
    Mass (Da):55,962
    Last modified:January 1, 1998 - v1
    Checksum:iD5713A214372E541
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016293 mRNA. Translation: AAB81719.1.
    RefSeqiNP_001274499.1. NM_001287570.1.
    XP_005692483.1. XM_005692426.1.
    XP_005692484.1. XM_005692427.1.
    UniGeneiChi.21605.

    Genome annotation databases

    GeneIDi102191547.
    KEGGichx:102191547.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016293 mRNA. Translation: AAB81719.1 .
    RefSeqi NP_001274499.1. NM_001287570.1.
    XP_005692483.1. XM_005692426.1.
    XP_005692484.1. XM_005692427.1.
    UniGenei Chi.21605.

    3D structure databases

    ProteinModelPortali O18809.
    SMRi O18809. Positions 27-491.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 102191547.
    KEGGi chx:102191547.

    Phylogenomic databases

    HOVERGENi HBG015789.
    KOi K07416.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR020469. Cyt_P450_CYP2_fam.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01957. EP450ICYP2F.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of CYP2F3, a cytochrome P450 that bioactivates the selective pneumotoxins 3-methylindole and naphthalene."
      Wang H., Lanza D.L., Yost G.S.
      Arch. Biochem. Biophys. 349:329-340(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiCP2F3_CAPHI
    AccessioniPrimary (citable) accession number: O18809
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3