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O18809 (CP2F3_CAPHI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2F3

EC=1.14.14.1
Alternative name(s):
CYPIIF3
Gene names
Name:CYP2F3
OrganismCapra hircus (Goat)
Taxonomic identifier9925 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. Stereoselectively catalyzes the formation of the 1R,2S-oxide from naphthalene. Lack activity with other common P450 substrates including 7-ethoxycoumarin.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Lung specific.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Cytochrome P450 2F3
PRO_0000051762

Sites

Metal binding4361Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O18809 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: D5713A214372E541

FASTA49155,962
        10         20         30         40         50         60 
MDSISTAILL LILALICLLL TTSSKGKGRL PPGPRALPFL GNLLQLRSQD MLTSLTKLSK 

        70         80         90        100        110        120 
EFGAVYTVYL GPRRVVVLSG YQAVKEALVD QAEEFSGRGD YPAFFNFTKG NGIAFSNGDR 

       130        140        150        160        170        180 
WKALRKYSLQ ILRNFGMGKR TIEERILEEG HFLLEELRKT QGKPFDPTFV VSRSVSNIIC 

       190        200        210        220        230        240 
SVIFGSRFDY DDDRLLTIIH LINENFQIMS SPWGEMYNIF PNLLDWVPGP HRRLFKNYGR 

       250        260        270        280        290        300 
MKNLIARSVR EHQASLDPNS PRDFIDCFLT KMAQEKQDPL SHFFMDTLLM TTHNLLFGGT 

       310        320        330        340        350        360 
ETVGTTLRHA FRLLMKYPEV QVRVQEEIDR VVGRERLPTV EDRAEMPYTD AVIHEVQRFA 

       370        380        390        400        410        420 
DIIPMSLPHR VTRDTNFRGF TIPRGTDVIT LLNTVHYDPS QFLKPKEFNP EHFLDANMSF 

       430        440        450        460        470        480 
KKSPAFMPFS AGRRLCLGEA LARMELFLYL TAILQSFSLQ PLGAPEDIDL TPLSSGLGNV 

       490 
PRPYQLCVRA R 

« Hide

References

[1]"Cloning and expression of CYP2F3, a cytochrome P450 that bioactivates the selective pneumotoxins 3-methylindole and naphthalene."
Wang H., Lanza D.L., Yost G.S.
Arch. Biochem. Biophys. 349:329-340(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF016293 mRNA. Translation: AAB81719.1.
RefSeqNP_001274499.1. NM_001287570.1.
XP_005692483.1. XM_005692426.1.
XP_005692484.1. XM_005692427.1.
UniGeneChi.21605.

3D structure databases

ProteinModelPortalO18809.
SMRO18809. Positions 27-491.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102191547.
KEGGchx:102191547.

Phylogenomic databases

HOVERGENHBG015789.
KOK07416.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR020469. Cyt_P450_CYP2_fam.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01957. EP450ICYP2F.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2F3_CAPHI
AccessionPrimary (citable) accession number: O18809
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families