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Protein

Beta-hexosaminidase

Gene

HEXB

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei297Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationImported, Hydrolase

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
Gene namesi
Name:HEXBImported
OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000016100.

Structurei

3D structure databases

ProteinModelPortaliO18795.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 120Glycohydro_20b2InterPro annotationAdd BLAST119
Domaini142 – 458Glyco_hydro_20InterPro annotationAdd BLAST317

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2499. Eukaryota.
COG3525. LUCA.
HOVERGENiHBG005961.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view]
PfamiPF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view]
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

O18795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSVKTSPR LLHLSRDNFS IGYGPSSTAG PTCSLLQEAF RRYHEYIFGF
60 70 80 90 100
DKRQRRPAKP NSAIELQQLL VTVVLDSECD LFPNITSDES YTLLVKEPVA
110 120 130 140 150
FLKANRVWGV LRGLETFSQL IYQDSYGTFT VNESDIIDSP RFPHRGILID
160 170 180 190 200
TARHFLPVKS ILKTLDAMAF NKFNVLHWHI VDDQSFPYQS VTFPELSNKG
210 220 230 240 250
SYSLSHVYTP NDVHTVIEYA RLRGIRVIPE FDSPGHTQSW GKGQKDLLTP
260 270 280 290 300
CYNEHKQSGT FGPINPILNS TYNFLSQFFK EVSMVFPDHF VHLGGDEVEF
310 320 330 340 350
QCWESNPEIQ GFMKQKGFGK DFRRLESFYL QKLLGIVSTV KKGSIVWQEV
360 370 380 390 400
FDDHVKLLPG TIVQVWKNQV YTEELREVTA AGFPVILSAP WYLDWISYGQ
410 420 430 440 450
DWRNYYKVDP LHFDGSQEQK KLVIGGEACL WGEFVDATNL TPRLWPRASA
460 470 480 490
VGERLWSPED ITSVGNAYNR LTVHRCRMVR RGISAEPLLY S
Length:491
Mass (Da):56,283
Last modified:January 1, 1998 - v1
Checksum:iD16717B58471D564
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014805 mRNA. Translation: AAB67612.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014805 mRNA. Translation: AAB67612.1.

3D structure databases

ProteinModelPortaliO18795.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000016100.

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2499. Eukaryota.
COG3525. LUCA.
HOVERGENiHBG005961.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view]
PfamiPF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view]
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO18795_FELCA
AccessioniPrimary (citable) accession number: O18795
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.