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Protein

Beta-defensin 1

Gene

DEFB1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 1
Short name:
BD-1
Alternative name(s):
Defensin, beta 1
RhBD-1
Gene namesi
Name:DEFB1
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 8

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 3211By similarityPRO_0000006909Add
BLAST
Peptidei33 – 6836Beta-defensin 1PRO_0000006910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 66By similarity
Disulfide bondi44 ↔ 59By similarity
Disulfide bondi49 ↔ 67By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

BgeeiENSMMUG00000003796.
ExpressionAtlasiO18794. baseline.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000005058.

Structurei

3D structure databases

ProteinModelPortaliO18794.
SMRiO18794. Positions 33-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7H1. Eukaryota.
ENOG41119QC. LUCA.
GeneTreeiENSGT00390000017014.
HOGENOMiHOG000112188.
HOVERGENiHBG084156.
InParanoidiO18794.
OMAiKIQGTCY.
OrthoDBiEOG091G18L0.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O18794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTSYLLLFT LCLLLSEMAS GDNFLTGLGH RSDHYNCVRS GGQCLYSACP
60
IYTRIQGTCY HGKAKCCK
Length:68
Mass (Da):7,572
Last modified:January 1, 1998 - v1
Checksum:i997336DEC3B0435E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014016 mRNA. Translation: AAB66344.1.
AF288285 mRNA. Translation: AAK26258.1.
RefSeqiNP_001028029.1. NM_001032857.1.
UniGeneiMmu.2163.

Genome annotation databases

EnsembliENSMMUT00000005370; ENSMMUP00000005058; ENSMMUG00000003796.
GeneIDi574187.
KEGGimcc:574187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014016 mRNA. Translation: AAB66344.1.
AF288285 mRNA. Translation: AAK26258.1.
RefSeqiNP_001028029.1. NM_001032857.1.
UniGeneiMmu.2163.

3D structure databases

ProteinModelPortaliO18794.
SMRiO18794. Positions 33-68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000005058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000005370; ENSMMUP00000005058; ENSMMUG00000003796.
GeneIDi574187.
KEGGimcc:574187.

Organism-specific databases

CTDi1672.

Phylogenomic databases

eggNOGiENOG410J7H1. Eukaryota.
ENOG41119QC. LUCA.
GeneTreeiENSGT00390000017014.
HOGENOMiHOG000112188.
HOVERGENiHBG084156.
InParanoidiO18794.
OMAiKIQGTCY.
OrthoDBiEOG091G18L0.

Gene expression databases

BgeeiENSMMUG00000003796.
ExpressionAtlasiO18794. baseline.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEFB1_MACMU
AccessioniPrimary (citable) accession number: O18794
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.