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Protein

Beta-defensin 1

Gene

DEFB1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 1
Short name:
BD-1
Alternative name(s):
Defensin, beta 1
RhBD-1
Gene namesi
Name:DEFB1
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000000690922 – 32By similarityAdd BLAST11
PeptideiPRO_000000691033 – 68Beta-defensin 1Add BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 66By similarity
Disulfide bondi44 ↔ 59By similarity
Disulfide bondi49 ↔ 67By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

BgeeiENSMMUG00000003796.

Interactioni

Subunit structurei

Monomer. Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000005058.

Structurei

3D structure databases

ProteinModelPortaliO18794.
SMRiO18794.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7H1. Eukaryota.
ENOG41119QC. LUCA.
HOGENOMiHOG000112188.
HOVERGENiHBG084156.
InParanoidiO18794.
OMAiKIQGTCY.
OrthoDBiEOG091G18L0.

Family and domain databases

InterProiView protein in InterPro
IPR001855. Defensin_beta-typ.
PfamiView protein in Pfam
PF00711. Defensin_beta. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O18794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTSYLLLFT LCLLLSEMAS GDNFLTGLGH RSDHYNCVRS GGQCLYSACP
60
IYTRIQGTCY HGKAKCCK
Length:68
Mass (Da):7,572
Last modified:January 1, 1998 - v1
Checksum:i997336DEC3B0435E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014016 mRNA. Translation: AAB66344.1.
AF288285 mRNA. Translation: AAK26258.1.
RefSeqiNP_001028029.1. NM_001032857.1.
UniGeneiMmu.2163.

Genome annotation databases

GeneIDi574187.
KEGGimcc:574187.

Similar proteinsi

Entry informationi

Entry nameiDEFB1_MACMU
AccessioniPrimary (citable) accession number: O18794
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families