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Protein

C-C chemokine receptor type 2

Gene

CCR2

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 2
Short name:
C-C CKR-2
Short name:
CC-CKR-2
Short name:
CCR-2
Short name:
CCR2
Alternative name(s):
Monocyte chemoattractant protein 1 receptor
Short name:
MCP-1-R
CD_antigen: CD192
Gene namesi
Name:CCR2
Synonyms:CMKBR2
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
Transmembranei43 – 70Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini71 – 80CytoplasmicSequence analysis10
Transmembranei81 – 100Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini101 – 114ExtracellularSequence analysisAdd BLAST14
Transmembranei115 – 136Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini137 – 153CytoplasmicSequence analysisAdd BLAST17
Transmembranei154 – 178Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini179 – 206ExtracellularSequence analysisAdd BLAST28
Transmembranei207 – 226Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini227 – 243CytoplasmicSequence analysisAdd BLAST17
Transmembranei244 – 268Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini269 – 285ExtracellularSequence analysisAdd BLAST17
Transmembranei286 – 309Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini310 – 360CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692331 – 360C-C chemokine receptor type 2Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Modified residuei26SulfotyrosineBy similarity1
Disulfide bondi32 ↔ 277PROSITE-ProRule annotation
Disulfide bondi113 ↔ 190PROSITE-ProRule annotation
Modified residuei139Phosphotyrosine; by JAK2By similarity1

Post-translational modificationi

Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Interactioni

Subunit structurei

Interacts with ARRB1.By similarity

Structurei

3D structure databases

ProteinModelPortaliO18793.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO18793.
KOiK04177.

Family and domain databases

InterProiIPR002237. Chemokine_CCR2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01107. CHEMOKINER2.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: O18793-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSTSRSRFI RNTNGSGEEV TTFFDYDYGA PCHKFDVKQI GAQLLPPLYS
60 70 80 90 100
LVFIFGFVGN MLVVLILINC KKLKSLTDIY LLNLAISDLL FLITLPLWAH
110 120 130 140 150
SAANEWVFGN AMCKLFTGLY HIGYLGGIFF IILLTIDRYL AIVHAVFALK
160 170 180 190 200
ARTVTFGVVT SVITWLVAVF ASVPGIIFTK CQEEDSVYIC GPYFPRGWNN
210 220 230 240 250
FHTIMRNILG LVLPLLIMVI CYSGILKTLL RCRNEKKRHR AVRLIFTIMI
260 270 280 290 300
VYFLFWTPYN IVILLNTFQE FFGLSNCEST RQLDQATQVT ETLGMTHCCI
310 320 330 340 350
NPIIYAFVGE KFRRYLSMFF RKYITKRFCK QCPVFYRETV DGVTSTNTPS
360
TAEQEVSVGL
Length:360
Mass (Da):41,140
Last modified:May 1, 1999 - v2
Checksum:i4B2552BCE913FE9F
GO
Isoform A (identifier: O18793-2)
Sequence is not available
Length:
Mass (Da):

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013958 mRNA. Translation: AAD11572.1.
RefSeqiNP_001027978.1. NM_001032806.1. [O18793-1]
UniGeneiMmu.3460.

Genome annotation databases

GeneIDi574098.
KEGGimcc:574098.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013958 mRNA. Translation: AAD11572.1.
RefSeqiNP_001027978.1. NM_001032806.1. [O18793-1]
UniGeneiMmu.3460.

3D structure databases

ProteinModelPortaliO18793.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574098.
KEGGimcc:574098.

Organism-specific databases

CTDi729230.

Phylogenomic databases

HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO18793.
KOiK04177.

Family and domain databases

InterProiIPR002237. Chemokine_CCR2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01107. CHEMOKINER2.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR2_MACMU
AccessioniPrimary (citable) accession number: O18793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.