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Protein

C-C chemokine receptor type 2

Gene

CCR2

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 2
Short name:
C-C CKR-2
Short name:
CC-CKR-2
Short name:
CCR-2
Short name:
CCR2
Alternative name(s):
Monocyte chemoattractant protein 1 receptor
Short name:
MCP-1-R
CD_antigen: CD192
Gene namesi
Name:CCR2
Synonyms:CMKBR2
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242ExtracellularSequence analysisAdd
BLAST
Transmembranei43 – 7028Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini71 – 8010CytoplasmicSequence analysis
Transmembranei81 – 10020Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini101 – 11414ExtracellularSequence analysisAdd
BLAST
Transmembranei115 – 13622Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini137 – 15317CytoplasmicSequence analysisAdd
BLAST
Transmembranei154 – 17825Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini179 – 20628ExtracellularSequence analysisAdd
BLAST
Transmembranei207 – 22620Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini227 – 24317CytoplasmicSequence analysisAdd
BLAST
Transmembranei244 – 26825Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini269 – 28517ExtracellularSequence analysisAdd
BLAST
Transmembranei286 – 30924Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini310 – 36051CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360C-C chemokine receptor type 2PRO_0000069233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence analysis
Modified residuei26 – 261SulfotyrosineBy similarity
Disulfide bondi32 ↔ 277PROSITE-ProRule annotation
Disulfide bondi113 ↔ 190PROSITE-ProRule annotation
Modified residuei139 – 1391Phosphotyrosine; by JAK2By similarity

Post-translational modificationi

Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Interactioni

Subunit structurei

Interacts with ARRB1.By similarity

Structurei

3D structure databases

ProteinModelPortaliO18793.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO18793.
KOiK04177.

Family and domain databases

InterProiIPR002237. Chemokine_CCR2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01107. CHEMOKINER2.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: O18793-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSTSRSRFI RNTNGSGEEV TTFFDYDYGA PCHKFDVKQI GAQLLPPLYS
60 70 80 90 100
LVFIFGFVGN MLVVLILINC KKLKSLTDIY LLNLAISDLL FLITLPLWAH
110 120 130 140 150
SAANEWVFGN AMCKLFTGLY HIGYLGGIFF IILLTIDRYL AIVHAVFALK
160 170 180 190 200
ARTVTFGVVT SVITWLVAVF ASVPGIIFTK CQEEDSVYIC GPYFPRGWNN
210 220 230 240 250
FHTIMRNILG LVLPLLIMVI CYSGILKTLL RCRNEKKRHR AVRLIFTIMI
260 270 280 290 300
VYFLFWTPYN IVILLNTFQE FFGLSNCEST RQLDQATQVT ETLGMTHCCI
310 320 330 340 350
NPIIYAFVGE KFRRYLSMFF RKYITKRFCK QCPVFYRETV DGVTSTNTPS
360
TAEQEVSVGL
Length:360
Mass (Da):41,140
Last modified:May 1, 1999 - v2
Checksum:i4B2552BCE913FE9F
GO
Isoform A (identifier: O18793-2)

Sequence is not available
Length:
Mass (Da):

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013958 mRNA. Translation: AAD11572.1.
RefSeqiNP_001027978.1. NM_001032806.1. [O18793-1]
UniGeneiMmu.3460.

Genome annotation databases

GeneIDi574098.
KEGGimcc:574098.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013958 mRNA. Translation: AAD11572.1.
RefSeqiNP_001027978.1. NM_001032806.1. [O18793-1]
UniGeneiMmu.3460.

3D structure databases

ProteinModelPortaliO18793.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574098.
KEGGimcc:574098.

Organism-specific databases

CTDi729230.

Phylogenomic databases

HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO18793.
KOiK04177.

Miscellaneous databases

NextBioi19985567.

Family and domain databases

InterProiIPR002237. Chemokine_CCR2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01107. CHEMOKINER2.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and comparison of eleven rhesus macaque chemokine receptors."
    Margulies B.J., Hauer D.A., Clements J.E.
    AIDS Res. Hum. Retroviruses 17:981-986(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCR2_MACMU
AccessioniPrimary (citable) accession number: O18793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.