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Protein

Short transient receptor potential channel 1

Gene

TRPC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 1
Short name:
TrpC1
Alternative name(s):
Transient receptor protein 1
Short name:
TRP-1
Gene namesi
Name:TRPC1
Synonyms:TRP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 386386CytoplasmicSequence analysisAdd
BLAST
Transmembranei387 – 40721HelicalSequence analysisAdd
BLAST
Topological domaini408 – 4158ExtracellularSequence analysis
Transmembranei416 – 43621HelicalSequence analysisAdd
BLAST
Topological domaini437 – 49054CytoplasmicSequence analysisAdd
BLAST
Transmembranei491 – 51121HelicalSequence analysisAdd
BLAST
Topological domaini512 – 53928ExtracellularSequence analysisAdd
BLAST
Transmembranei540 – 56021HelicalSequence analysisAdd
BLAST
Topological domaini561 – 58626CytoplasmicSequence analysisAdd
BLAST
Transmembranei587 – 60721HelicalSequence analysisAdd
BLAST
Topological domaini608 – 6169ExtracellularSequence analysis
Transmembranei617 – 63721HelicalSequence analysisAdd
BLAST
Topological domaini638 – 793156CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 793793Short transient receptor potential channel 1PRO_0000215302Add
BLAST

Post-translational modificationi

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO18784.
PRIDEiO18784.

Interactioni

Subunit structurei

Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4. Interacts with TRPC4AP.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002887.

Structurei

3D structure databases

ProteinModelPortaliO18784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati46 – 7530ANK 1Add
BLAST
Repeati83 – 11129ANK 2Add
BLAST
Repeati112 – 13827ANK 3Add
BLAST
Repeati158 – 18730ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
HOVERGENiHBG068337.
InParanoidiO18784.
KOiK04964.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: O18784-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAALYPSTD LSGASSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL
60 70 80 90 100
FLLACDKGDY YMVKEILEEN SSGDLNINCV DVLGRNAVTI TIENENLDIL
110 120 130 140 150
QLLLDYGCQS ADALLVAIDS EVVGAVDILL NHRPKRSSRP TIVKLMERIQ
160 170 180 190 200
NPEYSTTMDV APVILAAHRN NYEILTMLLK QDVSLPKPHA VGCECTLCSA
210 220 230 240 250
KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILGAFEL SADLKELSLV
260 270 280 290 300
EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS NDEPLDKRGL
310 320 330 340 350
LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK
360 370 380 390 400
IMTVLTVGIF WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL
410 420 430 440 450
LNLYSLVYHE DKKNTMGPAL ERIDYLLILW IIGMIWSDIK RLWYEGLEDF
460 470 480 490 500
LEESRNQLSF VMNSLYLATF ALKEEAHNKF HDFADRKDWD AFHPTLVAEG
510 520 530 540 550
LFAFANVLSY LRLFFYVYTS SILGPLQISM GRMLQDFGKF LGMFLLVLFS
560 570 580 590 600
FTIGLTQLYD KGYTPKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS
610 620 630 640 650
LAHVAILCTR FSYGEELQSF VGAFIVGTYN VVVVIVLTKL LVAMLHKSFQ
660 670 680 690 700
LIANHEDKEW KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK
710 720 730 740 750
WICSHTSKGK VKRQNSLKEW RHLNEKRDEN YQKVMCCLVR RYLTSMRQKM
760 770 780 790
QSTDQATVEN LNELRQDLSK FRNEIRDLLG FRTSKYAMFY PRN
Length:793
Mass (Da):91,339
Last modified:January 1, 1998 - v1
Checksum:i4A790FA203C0365B
GO
Isoform Short (identifier: O18784-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-143: Missing.

Show »
Length:759
Mass (Da):87,744
Checksum:i5838C29EF2197AF2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei110 – 14334Missing in isoform Short. 1 PublicationVSP_006559Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012900 mRNA. Translation: AAC48771.1.
AF012901 mRNA. Translation: AAC48772.1.
RefSeqiNP_776901.1. NM_174476.2. [O18784-1]
UniGeneiBt.49745.

Genome annotation databases

GeneIDi282100.
KEGGibta:282100.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012900 mRNA. Translation: AAC48771.1.
AF012901 mRNA. Translation: AAC48772.1.
RefSeqiNP_776901.1. NM_174476.2. [O18784-1]
UniGeneiBt.49745.

3D structure databases

ProteinModelPortaliO18784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002887.

Proteomic databases

PaxDbiO18784.
PRIDEiO18784.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282100.
KEGGibta:282100.

Organism-specific databases

CTDi7220.

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
HOVERGENiHBG068337.
InParanoidiO18784.
KOiK04964.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC1_BOVIN
AccessioniPrimary (citable) accession number: O18784
Secondary accession number(s): O18785
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.