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Reviewed, UniProtKB/Swiss-Prot O18778 (PAHX_BOVIN)

Last modified June 16, 2009. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Phytanoyl-CoA dioxygenase, peroxisomal
    EC=1.14.11.18
Alternative name(s):
    Phytanoyl-CoA alpha-hydroxylase
      Short name=PhyH
    Phytanic acid oxidase
Gene names
Name: PHYH
Synonyms: LN1, PAHX
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.

Catalytic activity

Phytanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyphytanoyl-CoA + succinate + CO2.

Cofactor

Iron.

Ascorbate.

Pathway

Lipid metabolism; fatty acid metabolism.

Subunit structure

Interacts specifically with the immunophilin FKBP52 and PHYHIP By similarity.

Subcellular location

Peroxisome.

Sequence similarities

Belongs to the PhyH family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3030Peroxisome By similarity
Chain31 – 337307Phytanoyl-CoA dioxygenase, peroxisomal
PRO_0000024052

Regions

Region175 – 1773Alpha-ketoglutarate binding By similarity

Sites

Metal binding1751Iron By similarity
Metal binding1771Iron By similarity
Metal binding2641Iron By similarity
Binding site1201Alpha-ketoglutarate By similarity
Binding site1571Alpha-ketoglutarate By similarity
Binding site1931Alpha-ketoglutarate By similarity
Binding site2661Alpha-ketoglutarate By similarity
Binding site2751Alpha-ketoglutarate By similarity

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Sequences

Sequence LengthMass (Da)Tools
O18778-1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: D6A261C1BF6FE76F

FASTA33738,770
        10         20         30         40         50         60 
MDRNRASARL TVLLRHLGCR SAGTIIAHHT SGVGSLASFH PQQFQYTREN NVLSLEQRKF 

        70         80         90        100        110        120 
YEENGFLVIK NLVSDADIQR FRNEFERICR KEVKPLGLSV MRDVTITKSE YVPSEKVVSK 

       130        140        150        160        170        180 
VQDFQEDEEL FRYCTLPEIL KYVECFTGPN IMAMHTMLIN KPPDSGKKTS RHPLHQDLHY 

       190        200        210        220        230        240 
FPFRPSNSIV CAWTAMEHID RNNGCLVVLP GTHKGPLQPH DYPQWEGGVN IMFHGIQDYD 

       250        260        270        280        290        300 
KNNARVHLVM EKGDTVFFHP LLIHGSGRNK SQGFRKAISC HFADANCHYI DVEGTSQENI 

       310        320        330 
EKEVVDIVRK KYGFKDVTLK DVWTFRGRVV KGERINL

« Hide

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References

« Hide 'large scale' references
[1]Oshikawa Y., Carlson S.G., Lee J., Yoshizawa N., Ballermann B.J.
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

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Cross-references

Sequence databases

AF011925 mRNA. Translation: AAB65800.1.
BC102460 mRNA. Translation: AAI02461.1.
IPIIPI00713584.
RefSeqNP_776567.1.
UniGeneBt.35697

3D structure databases

SMRO18778. Positions 44-322.
ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000007700. Bos taurus. [Contig view]
GeneID281400.
KEGGbta:281400.

Phylogenomic databases

HOVERGENO18778.
OMAO18778. NIMFHGI.

Enzyme and pathway databases

BRENDA1.14.11.18. 251.

Family and domain databases

InterProIPR008775. Phytyl_CoA_dOase.
[Graphical view]
PfamPF05721. PhyH. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePAHX_BOVIN
AccessionPrimary (citable) accession number: O18778
Secondary accession number(s): Q3T0C0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 17, 2006
Last modified: June 16, 2009
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents