Reviewed, UniProtKB/Swiss-Prot O18778 (PAHX_BOVIN)

Names and origin

Protein names

Recommended name:
    Phytanoyl-CoA dioxygenase, peroxisomal
    EC=1.14.11.18
Alternative name(s):
    Phytanoyl-CoA alpha-hydroxylase
      Short name=PhyH
    Phytanic acid oxidase

Gene names

Name:	PHYH
Synonyms:	LN1, PAHX

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.
Catalytic activity	Phytanoyl-CoA + 2-oxoglutarate + O(2) = 2-hydroxyphytanoyl-CoA + succinate + CO(2).
Cofactor	Iron. Ascorbate.
Pathway	Lipid metabolism; fatty acid metabolism.
Subunit structure	Interacts specifically with the immunophilin FKBP52 and PHYHIP By similarity.
Subcellular location	Peroxisome.
Sequence similarities	Belongs to the PhyH family.

Ontologies

Keywords
Cellular component	Peroxisome
Domain	Transit peptide
Ligand	Iron Vitamin C
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-ascorbic acid binding Inferred from electronic annotation. Source: UniProtKB-KW iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW phytanoyl-CoA dioxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 30	30	Peroxisome By similarity
	Chain	31 – 337	307	Phytanoyl-CoA dioxygenase, peroxisomal		PRO_0000024052

Sequences

	Sequence		Length	Mass (Da)
	O18778-1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: D6A261C1BF6FE76F	FASTA	337	38,770
	10 20 30 40 50 60 MDRNRASARL TVLLRHLGCR SAGTIIAHHT SGVGSLASFH PQQFQYTREN NVLSLEQRKF 70 80 90 100 110 120 YEENGFLVIK NLVSDADIQR FRNEFERICR KEVKPLGLSV MRDVTITKSE YVPSEKVVSK 130 140 150 160 170 180 VQDFQEDEEL FRYCTLPEIL KYVECFTGPN IMAMHTMLIN KPPDSGKKTS RHPLHQDLHY 190 200 210 220 230 240 FPFRPSNSIV CAWTAMEHID RNNGCLVVLP GTHKGPLQPH DYPQWEGGVN IMFHGIQDYD 250 260 270 280 290 300 KNNARVHLVM EKGDTVFFHP LLIHGSGRNK SQGFRKAISC HFADANCHYI DVEGTSQENI 310 320 330 EKEVVDIVRK KYGFKDVTLK DVWTFRGRVV KGERINL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Oshikawa Y., Carlson S.G., Lee J., Yoshizawa N., Ballermann B.J. Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF011925 mRNA. Translation: AAB65800.1. BC102460 mRNA. Translation: AAI02461.1.
RefSeq	NP_776567.1.
UniGene	Bt.35697
3D structure databases
SMR	O18778. Positions 44-322.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000007700. Bos taurus. [Contig view]
GeneID	281400.
KEGG	bta:281400.
Phylogenomic databases
HOVERGEN	O18778.
Family and domain databases
InterPro	IPR008775. Phytyl_CoA_dOase. [Graphical view]
Pfam	PF05721. PhyH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PAHX_BOVIN

Accession

Primary (citable) accession number: O18778
Secondary accession number(s): Q3T0C0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	October 17, 2006
Last modified:	November 4, 2008
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)