Reviewed,
UniProtKB/Swiss-Prot O18778 (PAHX_BOVIN)
Last modified
June 16, 2009.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Phytanoyl-CoA dioxygenase, peroxisomal EC=1.14.11.18 Alternative name(s): Phytanoyl-CoA alpha-hydroxylase Short name=PhyH Phytanic acid oxidase | ||||
| Gene names |
| ||||
| Organism | Bos taurus (Bovine) | ||||
| Taxonomic identifier | 9913 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 337 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. |
| Catalytic activity | Phytanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyphytanoyl-CoA + succinate + CO2. |
| Cofactor | Iron. Ascorbate. |
| Pathway | |
| Subunit structure | Interacts specifically with the immunophilin FKBP52 and PHYHIP By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the PhyH family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Peroxisome |
| Domain | Transit peptide |
| Ligand | Iron Metal-binding Vitamin C |
| Molecular function | Dioxygenase Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | L-ascorbic acid binding Inferred from electronic annotation. Source: UniProtKB-KW iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenInferred from electronic annotation. Source: UniProtKB-KW phytanoyl-CoA dioxygenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 30 | 30 | Peroxisome By similarity | ||||||
| Chain | 31 – 337 | 307 | Phytanoyl-CoA dioxygenase, peroxisomal | PRO_0000024052 | |||||
Regions | |||||||||
| Region | 175 – 177 | 3 | Alpha-ketoglutarate binding By similarity | ||||||
Sites | |||||||||
| Metal binding | 175 | 1 | Iron By similarity | ||||||
| Metal binding | 177 | 1 | Iron By similarity | ||||||
| Metal binding | 264 | 1 | Iron By similarity | ||||||
| Binding site | 120 | 1 | Alpha-ketoglutarate By similarity | ||||||
| Binding site | 157 | 1 | Alpha-ketoglutarate By similarity | ||||||
| Binding site | 193 | 1 | Alpha-ketoglutarate By similarity | ||||||
| Binding site | 266 | 1 | Alpha-ketoglutarate By similarity | ||||||
| Binding site | 275 | 1 | Alpha-ketoglutarate By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | Oshikawa Y., Carlson S.G., Lee J., Yoshizawa N., Ballermann B.J. Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum. |
Cross-references
Sequence databases | |
|---|---|
| AF011925 mRNA. Translation: AAB65800.1. BC102460 mRNA. Translation: AAI02461.1. | |
| IPI | IPI00713584. |
| RefSeq | NP_776567.1. |
| UniGene | Bt.35697 |
3D structure databases | |
| SMR | O18778. Positions 44-322. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAG00000007700. Bos taurus. [Contig view] |
| GeneID | 281400. |
| KEGG | bta:281400. |
Phylogenomic databases | |
| HOVERGEN | O18778. |
| OMA | O18778. NIMFHGI. |
Enzyme and pathway databases | |
| BRENDA | 1.14.11.18. 251. |
Family and domain databases | |
| InterPro | IPR008775. Phytyl_CoA_dOase. [Graphical view] |
| Pfam | PF05721. PhyH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PAHX_BOVIN | ||||||||
| Accession | Primary (citable) accession number: O18778 Secondary accession number(s): Q3T0C0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


