ID   S5A2_PIG                Reviewed;         254 AA.
AC   O18765;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 2.
DT   16-JUN-2009, entry version 52.
DE   RecName: Full=3-oxo-5-alpha-steroid 4-dehydrogenase 2;
DE            EC=1.3.99.5;
DE   AltName: Full=Steroid 5-alpha-reductase 2;
DE   AltName: Full=5 alpha-SR2;
DE   AltName: Full=SR type 2;
GN   Name=SRD5A2; Synonyms=ST5AR2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Epididymis;
RA   Lacroix D.A., Men T., Houde A., Murphy B.D.;
RL   Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Converts testosterone (T) into 5-alpha-
CC       dihydrotestosterone (DHT) and progesterone or corticosterone into
CC       their corresponding 5-alpha-3-oxosteroids. It plays a central role
CC       in sexual differentiation and androgen physiology (By similarity).
CC   -!- CATALYTIC ACTIVITY: A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-
CC       Delta(4)-steroid + reduced acceptor.
CC   -!- SUBCELLULAR LOCATION: Microsome membrane; Multi-pass membrane
CC       protein (By similarity). Endoplasmic reticulum membrane; Multi-
CC       pass membrane protein (Potential).
CC   -!- SIMILARITY: Belongs to the steroid 5-alpha reductase family.
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DR   EMBL; AF008440; AAB69279.2; -; mRNA.
DR   RefSeq; NP_999153.1; -.
DR   UniGene; Ssc.1; -.
DR   GeneID; 397048; -.
DR   KEGG; ssc:397048; -.
DR   HOVERGEN; O18765; -.
DR   BRENDA; 1.3.99.5; 249.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
DR   GO; GO:0003865; F:3-oxo-5-alpha-steroid 4-dehydrogenase activity; IEA:EC.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0007530; P:sex determination; IEA:UniProtKB-KW.
DR   GO; GO:0008202; P:steroid metabolic process; IEA:InterPro.
DR   InterPro; IPR016636; 3-oxo-5-alpha-steroid_4-DH.
DR   InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR   Pfam; PF02544; Steroid_dh; 1.
DR   PIRSF; PIRSF015596; 5_alpha-SR2; 1.
DR   PROSITE; PS50244; S5A_REDUCTASE; 1.
PE   2: Evidence at transcript level;
KW   Differentiation; Endoplasmic reticulum; Membrane; Microsome;
KW   Oxidoreductase; Sexual differentiation; Transmembrane.
FT   CHAIN         1    254       3-oxo-5-alpha-steroid 4-dehydrogenase 2.
FT                                /FTId=PRO_0000213679.
FT   TRANSMEM      8     28       Potential.
FT   TRANSMEM     72     92       Potential.
FT   TRANSMEM    146    166       Potential.
FT   TRANSMEM    206    226       Potential.
SQ   SEQUENCE   254 AA;  28536 MW;  F647B3D46AB98A29 CRC64;
     MPVRCQQSPV LAGSATLAAL GALALYFAEP SGYGKYTESL TPAAIRLPAR AAWFLQELPS
     FVVPAGILAG QPRSLFGPPA TVLLGLFCAH YFHRTFVYSL LTRGRPFPVV FLFRGFVFCM
     GNGLLQGYYL VYCAEYPAEW YTDIRFSLGV FLFILGMGIN IHSDYILRQL RKPGEVIYKI
     PQGGLFTYVS GANFLGEIIE WIGYALATWS LPALAFAFFS LCFLGLRAFH HHRFYVKMFE
     DYPKSRKALI PFIF
//