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O18765

- S5A2_PIG

UniProt

O18765 - S5A2_PIG

Protein

3-oxo-5-alpha-steroid 4-dehydrogenase 2

Gene

SRD5A2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology By similarity.By similarity

    Catalytic activityi

    A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + NADPH.

    GO - Molecular functioni

    1. 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: Ensembl
    2. cholestenone 5-alpha-reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. androgen biosynthetic process Source: Ensembl
    2. cell differentiation Source: UniProtKB-KW
    3. male genitalia development Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Differentiation, Sexual differentiation

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC:1.3.1.22)
    Alternative name(s):
    5 alpha-SR2
    SR type 2
    Steroid 5-alpha-reductase 2
    Short name:
    S5AR 2
    Gene namesi
    Name:SRD5A2
    Synonyms:ST5AR2
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2542543-oxo-5-alpha-steroid 4-dehydrogenase 2PRO_0000213679Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000009087.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the steroid 5-alpha reductase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG282706.
    HOGENOMiHOG000050133.
    HOVERGENiHBG003402.
    KOiK12344.

    Family and domain databases

    InterProiIPR016636. 3-oxo-5-alpha-steroid_4-DH.
    IPR001104. 3-oxo-5_a-steroid_4-DH_C.
    [Graphical view]
    PfamiPF02544. Steroid_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015596. 5_alpha-SR2. 1 hit.
    PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O18765-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVRCQQSPV LAGSATLAAL GALALYFAEP SGYGKYTESL TPAAIRLPAR    50
    AAWFLQELPS FVVPAGILAG QPRSLFGPPA TVLLGLFCAH YFHRTFVYSL 100
    LTRGRPFPVV FLFRGFVFCM GNGLLQGYYL VYCAEYPAEW YTDIRFSLGV 150
    FLFILGMGIN IHSDYILRQL RKPGEVIYKI PQGGLFTYVS GANFLGEIIE 200
    WIGYALATWS LPALAFAFFS LCFLGLRAFH HHRFYVKMFE DYPKSRKALI 250
    PFIF 254
    Length:254
    Mass (Da):28,536
    Last modified:October 1, 2001 - v2
    Checksum:iF647B3D46AB98A29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF008440 mRNA. Translation: AAB69279.2.
    RefSeqiNP_999153.1. NM_213988.1.
    UniGeneiSsc.1.

    Genome annotation databases

    GeneIDi397048.
    KEGGissc:397048.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF008440 mRNA. Translation: AAB69279.2 .
    RefSeqi NP_999153.1. NM_213988.1.
    UniGenei Ssc.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000009087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397048.
    KEGGi ssc:397048.

    Organism-specific databases

    CTDi 397048.

    Phylogenomic databases

    eggNOGi NOG282706.
    HOGENOMi HOG000050133.
    HOVERGENi HBG003402.
    KOi K12344.

    Family and domain databases

    InterProi IPR016636. 3-oxo-5-alpha-steroid_4-DH.
    IPR001104. 3-oxo-5_a-steroid_4-DH_C.
    [Graphical view ]
    Pfami PF02544. Steroid_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015596. 5_alpha-SR2. 1 hit.
    PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Lacroix D.A., Men T., Houde A., Murphy B.D.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Epididymis.

    Entry informationi

    Entry nameiS5A2_PIG
    AccessioniPrimary (citable) accession number: O18765
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3