Reviewed, UniProtKB/Swiss-Prot O18765 (S5A2_PIG)

Names and origin

Protein names

Recommended name:
    3-oxo-5-alpha-steroid 4-dehydrogenase 2
    EC=1.3.99.5
Alternative name(s):
    Steroid 5-alpha-reductase 2
    5 alpha-SR2
    SR type 2

Gene names

Name:	SRD5A2
Synonyms:	ST5AR2

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology By similarity.
Catalytic activity	A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor.
Subcellular location	Microsome membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the steroid 5-alpha reductase family.

Ontologies

Keywords
Biological process	Differentiation Sexual differentiation
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Transmembrane
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW sex differentiation Inferred from electronic annotation. Source: UniProtKB-KW steroid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-oxo-5-alpha-steroid 4-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	3-oxo-5-alpha-steroid 4-dehydrogenase 2		PRO_0000213679
Regions
	Transmembrane	8 – 28	21	Potential
	Transmembrane	72 – 92	21	Potential
	Transmembrane	146 – 166	21	Potential
	Transmembrane	206 – 226	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	O18765-1 [UniParc]. Last modified October 1, 2001. Version 2. Checksum: F647B3D46AB98A29	FASTA	254	28,536
	10 20 30 40 50 60 MPVRCQQSPV LAGSATLAAL GALALYFAEP SGYGKYTESL TPAAIRLPAR AAWFLQELPS 70 80 90 100 110 120 FVVPAGILAG QPRSLFGPPA TVLLGLFCAH YFHRTFVYSL LTRGRPFPVV FLFRGFVFCM 130 140 150 160 170 180 GNGLLQGYYL VYCAEYPAEW YTDIRFSLGV FLFILGMGIN IHSDYILRQL RKPGEVIYKI 190 200 210 220 230 240 PQGGLFTYVS GANFLGEIIE WIGYALATWS LPALAFAFFS LCFLGLRAFH HHRFYVKMFE 250 DYPKSRKALI PFIF

References

[1]	Lacroix D.A., Men T., Houde A., Murphy B.D. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Epididymis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF008440 mRNA. Translation: AAB69279.2.
RefSeq	NP_999153.1.
UniGene	Ssc.1
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	397048.
KEGG	ssc:397048.
Organism-specific databases
CTD	397048.
Phylogenomic databases
HOVERGEN	O18765.
Enzyme and pathway databases
BRENDA	1.3.99.5. 249.
Family and domain databases
InterPro	IPR016636. 3-oxo-5-alpha-steroid_4-DH. IPR001104. 3-oxo-5_a-steroid_4-DH_C. [Graphical view]
Pfam	PF02544. Steroid_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015596. 5_alpha-SR2. 1 hit.
PROSITE	PS50244. S5A_REDUCTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

S5A2_PIG

Accession

Primary (citable) accession number: O18765

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	October 1, 2001
Last modified:	October 13, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)