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Protein

Calcium-binding mitochondrial carrier protein SCaMC-1

Gene

SLC25A24

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi32 – 431PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi68 – 792PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi99 – 1103PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi135 – 1464PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-1
Alternative name(s):
Peroxisomal Ca(2+)-dependent solute carrier
Small calcium-binding mitochondrial carrier protein 1
Solute carrier family 25 member 24
Gene namesi
Name:SLC25A24
Synonyms:EFINAL, SCAMC1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 197Mitochondrial intermembraneSequence analysisAdd BLAST197
Transmembranei198 – 215Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini216 – 250Mitochondrial matrixSequence analysisAdd BLAST35
Transmembranei251 – 270Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini271 – 293Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei294 – 307Helical; Name=3Sequence analysisAdd BLAST14
Topological domaini308 – 343Mitochondrial matrixSequence analysisAdd BLAST36
Transmembranei344 – 363Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini364 – 386Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei387 – 404Helical; Name=5Sequence analysisAdd BLAST18
Topological domaini405 – 443Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei444 – 463Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini464 – 475Mitochondrial intermembraneSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175961 – 475Calcium-binding mitochondrial carrier protein SCaMC-1Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei318N6-acetyllysine; alternateBy similarity1
Modified residuei318N6-succinyllysine; alternateBy similarity1
Modified residuei334N6-acetyllysineBy similarity1
Modified residuei435N6-acetyllysine; alternateBy similarity1
Modified residuei435N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiO18757

Expressioni

Tissue specificityi

Mainly expressed in colon. Also expressed in the small intestine proximal to the ileum. Weakly expressed in kidney but not in the liver.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000017468

Structurei

3D structure databases

ProteinModelPortaliO18757
SMRiO18757
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 54EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini55 – 88EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini86 – 121EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini122 – 157EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Repeati192 – 276Solcar 1Add BLAST85
Repeati284 – 369Solcar 2Add BLAST86
Repeati381 – 469Solcar 3Add BLAST89

Domaini

The N-terminal domain can bind calcium and regulates the ATP carrier activity of the transmembrane domain. The apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, leading to inhibition of the ATP carrier activity. Calcium binding leads to a major conformation change and abolishes the interaction with the transmembrane domain and the inhibition of the ATP carrier activity (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036 Eukaryota
ENOG410XQ4P LUCA
HOGENOMiHOG000165728
HOVERGENiHBG108464
InParanoidiO18757
KOiK14684

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
PF00153 Mito_carr, 3 hits
PRINTSiPR00928 GRAVESDC
PR00926 MITOCARRIER
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

O18757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWLRGFVL PTAACQGAEP PTRYETLFQA LDRNGDGVVD IRELQEGLKS
60 70 80 90 100
LGIPLGQDAE EKIFTTGDVN KDGKLDFEEF MKYLKDHEKK MKLAFKSLDK
110 120 130 140 150
NNDGKIEASE IVQSLQTLGL TISEQQAELI LQSIDADGTM TVDWNEWRDY
160 170 180 190 200
FLFNPVADIE EIIRFWKHST GIDIGDSLTI PDEFTEEERK SGQWWRQLLA
210 220 230 240 250
GGIAGAVSRT STAPLDRLKV MMQVHGSKSM NIFGGFRQMI KEGGVRSLWR
260 270 280 290 300
GNGTNVIKIA PETAVKFWVY EQYKKLLTEE GQKIGTFERF ISGSMAGATA
310 320 330 340 350
QTFIYPMEVM KTRLAVGKTG QYSGIYDCAK KILKYEGFGA FYKGYVPNLL
360 370 380 390 400
GIIPYAGIDL AVYELLKSHW LDNFAKDSVN PGVLVLLGCG ALSSTCGQLA
410 420 430 440 450
SYPLALVRTR MQAQAMLEGA PQLNMVGLFR RIISKEGLPG LYRGITPNFM
460 470
KVLPAVGISY VVYENMKQTL GVTQK
Length:475
Mass (Da):53,006
Last modified:January 1, 1998 - v1
Checksum:iE779D43F7C758269
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004161 mRNA Translation: AAB69156.1
PIRiT50686
RefSeqiNP_001076246.1, NM_001082777.1
UniGeneiOcu.2170

Genome annotation databases

GeneIDi100009567
KEGGiocu:100009567

Similar proteinsi

Entry informationi

Entry nameiSCMC1_RABIT
AccessioniPrimary (citable) accession number: O18757
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 1, 1998
Last modified: November 22, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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