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Protein

Keratin, type I cytoskeletal 9

Gene

KRT9

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 9
Alternative name(s):
Cytokeratin-9
Short name:
CK-9
Keratin-9
Short name:
K9
Gene namesi
Name:KRT9Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 786786Keratin, type I cytoskeletal 9PRO_0000308371Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO18740.
PRIDEiO18740.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000023465.

Structurei

3D structure databases

ProteinModelPortaliO18740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 136136HeadSequence analysisAdd
BLAST
Regioni137 – 445309RodSequence analysisAdd
BLAST
Regioni137 – 17236Coil 1ASequence analysisAdd
BLAST
Regioni173 – 19119Linker 1Sequence analysisAdd
BLAST
Regioni192 – 28392Coil 1BSequence analysisAdd
BLAST
Regioni284 – 30623Linker 12Sequence analysisAdd
BLAST
Regioni307 – 445139Coil 2Sequence analysisAdd
BLAST
Regioni446 – 760315TailSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 9285Ser-richSequence analysisAdd
BLAST
Compositional biasi17 – 134118Gly-richSequence analysisAdd
BLAST
Compositional biasi451 – 773323Ser-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEYG. Eukaryota.
ENOG4111C5Z. LUCA.
HOVERGENiHBG013015.
InParanoidiO18740.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 2 hits.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18740-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCRQFLSSH CSRDSSGGGG GSKMFSCNRS SFSGASGGGG RFSSSRSFGG
60 70 80 90 100
GSSGACGRGG GGSFGSSYGG GSGGGFSAGS FGGHSRGFSG GSGGGFGGGF
110 120 130 140 150
GGGFGGFSGG SGGGFGGPGG FGSGFDSGAG GILGADEKTT MQDLNSRLAS
160 170 180 190 200
YLDKVQALED ANKELESKIR EWYDKQGSRT FHRDYSPYYD TIEDLKNQIV
210 220 230 240 250
NITADNNKTL LDLDNTRMTL DDIRMKCDIE NNLRLAVNAD INGLRKVLDD
260 270 280 290 300
LTMQKSDLEM HYESLQEELI ALKKNHEDEM SQLTGQNSGD VNVEMNAAPG
310 320 330 340 350
RDLTKILNDM REEYERISAK NRKDIEEQYE TQMSQMEQEV MSSGQEMESN
360 370 380 390 400
HKEVTQLRHS IQEMEIELQS QLSKKSALEK SLEDTKNHYC GQLQQLQEQI
410 420 430 440 450
RSLEGQITEI RGEIECQNQE YSLLLNIKTR LEQEIKTYRS LLEGGQEDFE
460 470 480 490 500
SHESGQSHFG SGGSRQQGGI GGSHGRGSRG GSGGSYGGGS SSGGGSGGSH
510 520 530 540 550
GGGSGGSYGG GSSSGGGSGG RGGSGGSYGG GSGSGGGSSG SYGGGSSSGG
560 570 580 590 600
GSGGSHGGGS GGSYGGGSSS GGGSGGRGGS GGSYGGGSGS GGGRGGGCEE
610 620 630 640 650
GSGSGGRSGG SYGGGSGSGG GSSCSYGGGS SSGGGSGGSY GGGSSSGGGS
660 670 680 690 700
GGKGGSGCSY SGGSSSGGGS GGSYGGGSSS GRGSGGRGGS AGSYGGGSGS
710 720 730 740 750
GGGRGGGCEE GSGSGGRSGG SYGGGSGSGG RSGGSYGGGS GSGGGSGGSY
760 770 780
GGGSGSKGGS GRSSQVQSSS SKSGECDDTQ GYHIQY
Length:786
Mass (Da):76,354
Last modified:January 1, 1998 - v1
Checksum:i272AB5425DD09535
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti308 – 3081N → G.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000949 Genomic DNA. Translation: AAC26971.1.
UniGeneiCfa.38225.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000949 Genomic DNA. Translation: AAC26971.1.
UniGeneiCfa.38225.

3D structure databases

ProteinModelPortaliO18740.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000023465.

Proteomic databases

PaxDbiO18740.
PRIDEiO18740.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IEYG. Eukaryota.
ENOG4111C5Z. LUCA.
HOVERGENiHBG013015.
InParanoidiO18740.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 2 hits.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C9_CANLF
AccessioniPrimary (citable) accession number: O18740
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.