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Protein

Connective tissue growth factor

Gene

CTGF

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, DNA synthesis

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Connective tissue growth factor
Alternative name(s):
CCN family member 2
Gene namesi
Name:CTGF
Synonyms:CCN2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001440127 – 349Connective tissue growth factorAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi256 ↔ 293By similarity
Disulfide bondi273 ↔ 307By similarity
Disulfide bondi284 ↔ 323By similarity
Disulfide bondi287 ↔ 325By similarity
Disulfide bondi292 ↔ 329By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO18739.
PRIDEiO18739.

Expressioni

Gene expression databases

BgeeiENSBTAG00000006367.

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008357.

Structurei

3D structure databases

ProteinModelPortaliO18739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 98IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST72
Domaini101 – 167VWFCPROSITE-ProRule annotationAdd BLAST67
Domaini198 – 243TSP type-1PROSITE-ProRule annotationAdd BLAST46
Domaini256 – 330CTCKPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni247 – 349Heparin-bindingBy similarityAdd BLAST103

Sequence similaritiesi

Belongs to the CCN family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH0W. Eukaryota.
ENOG4111F77. LUCA.
GeneTreeiENSGT00760000119225.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiO18739.
KOiK06827.
OMAiKCIRTPR.
OrthoDBiEOG091G0SQP.
TreeFamiTF326070.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. TSP1_rpt.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O18739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATGLGPVR CAFVLLLALC SRPASSQDCS APCQCPAGPA PRCPAGVSLV
60 70 80 90 100
LDGCGCCRVC AKQLSELCTE RDPCDPHKGL FCDFGSPANR KIGVCTAKDG
110 120 130 140 150
APCVFGGTVY QSGESFQSSC KYQCTCLDGS VGCVPLCSVD VRLPSPDCPF
160 170 180 190 200
PRRVKLPGKC CEEWVCDEPK EHTVVGPALA AYRPEDTFGP DPTMIRANCL
210 220 230 240 250
VQTTEWSACS KTCGMGISTR VTNDNAFCRL EKQSRLCMVR PCEADLEENI
260 270 280 290 300
KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT
310 320 330 340
LPVEFKCPDG EVMKKSMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA
Length:349
Mass (Da):37,924
Last modified:February 11, 2002 - v2
Checksum:i5FFC8EE83EFB4F99
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28D → DC in AAB66596 (Ref. 1) Curated1
Sequence conflicti58Missing in AAB66596 (Ref. 1) Curated1
Sequence conflicti88A → T in AAB66596 (Ref. 1) Curated1
Sequence conflicti103 – 104CV → YI in AAB66596 (Ref. 1) Curated2
Sequence conflicti166 – 169CDEP → SRDE in AAB66596 (Ref. 1) Curated4
Sequence conflicti184P → L in AAB66596 (Ref. 1) Curated1
Sequence conflicti200L → Q in AAB66596 (Ref. 1) Curated1
Sequence conflicti209C → Y in AAB66596 (Ref. 1) Curated1
Sequence conflicti269E → Q in AAB66596 (Ref. 1) Curated1
Sequence conflicti284C → F in AAB66596 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000137 mRNA. Translation: AAB66596.1.
AF309555 Genomic DNA. Translation: AAG30290.1.
BC113279 mRNA. Translation: AAI13280.1.
RefSeqiNP_776455.1. NM_174030.2.
UniGeneiBt.5240.

Genome annotation databases

EnsembliENSBTAT00000008357; ENSBTAP00000008357; ENSBTAG00000006367.
GeneIDi281103.
KEGGibta:281103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000137 mRNA. Translation: AAB66596.1.
AF309555 Genomic DNA. Translation: AAG30290.1.
BC113279 mRNA. Translation: AAI13280.1.
RefSeqiNP_776455.1. NM_174030.2.
UniGeneiBt.5240.

3D structure databases

ProteinModelPortaliO18739.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008357.

Proteomic databases

PaxDbiO18739.
PRIDEiO18739.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008357; ENSBTAP00000008357; ENSBTAG00000006367.
GeneIDi281103.
KEGGibta:281103.

Organism-specific databases

CTDi1490.

Phylogenomic databases

eggNOGiENOG410IH0W. Eukaryota.
ENOG4111F77. LUCA.
GeneTreeiENSGT00760000119225.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiO18739.
KOiK06827.
OMAiKCIRTPR.
OrthoDBiEOG091G0SQP.
TreeFamiTF326070.

Gene expression databases

BgeeiENSBTAG00000006367.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. TSP1_rpt.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTGF_BOVIN
AccessioniPrimary (citable) accession number: O18739
Secondary accession number(s): Q2HJ71, Q9GL71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 11, 2002
Last modified: September 7, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.