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O18739

- CTGF_BOVIN

UniProt

O18739 - CTGF_BOVIN

Protein

Connective tissue growth factor

Gene

CTGF

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (11 Feb 2002)
      Previous versions | rss
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    Functioni

    Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes By similarity. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells By similarity. Enhances fibroblast growth factor-induced DNA synthesis By similarity.By similarity

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. cartilage condensation Source: Ensembl
    3. cell differentiation Source: Ensembl
    4. cell-matrix adhesion Source: Ensembl
    5. cell migration Source: Ensembl
    6. chondrocyte proliferation Source: Ensembl
    7. DNA replication Source: UniProtKB-KW
    8. fibroblast growth factor receptor signaling pathway Source: Ensembl
    9. integrin-mediated signaling pathway Source: Ensembl
    10. lung development Source: Ensembl
    11. negative regulation of gene expression Source: Ensembl
    12. ossification Source: Ensembl
    13. positive regulation of cell differentiation Source: Ensembl
    14. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    15. positive regulation of JNK cascade Source: Ensembl
    16. positive regulation of stress fiber assembly Source: Ensembl
    17. reactive oxygen species metabolic process Source: Ensembl
    18. regulation of cell growth Source: InterPro
    19. regulation of chondrocyte differentiation Source: Ensembl

    Keywords - Biological processi

    Cell adhesion, DNA synthesis

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_207237. PPARA activates gene expression.
    REACT_223100. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Connective tissue growth factor
    Alternative name(s):
    CCN family member 2
    Gene namesi
    Name:CTGF
    Synonyms:CCN2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 9

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix By similarity. Secreted By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 349323Connective tissue growth factorPRO_0000014401Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi256 ↔ 293By similarity
    Disulfide bondi273 ↔ 307By similarity
    Disulfide bondi284 ↔ 323By similarity
    Disulfide bondi287 ↔ 325By similarity
    Disulfide bondi292 ↔ 329By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiO18739.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO18739.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 9872IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini101 – 16767VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini198 – 24346TSP type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini256 – 33075CTCKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni247 – 349103Heparin-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG72934.
    GeneTreeiENSGT00750000117442.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiO18739.
    KOiK06827.
    OMAiKTYRAKF.
    OrthoDBiEOG7N8ZXB.
    TreeFamiTF326070.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O18739-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSATGLGPVR CAFVLLLALC SRPASSQDCS APCQCPAGPA PRCPAGVSLV    50
    LDGCGCCRVC AKQLSELCTE RDPCDPHKGL FCDFGSPANR KIGVCTAKDG 100
    APCVFGGTVY QSGESFQSSC KYQCTCLDGS VGCVPLCSVD VRLPSPDCPF 150
    PRRVKLPGKC CEEWVCDEPK EHTVVGPALA AYRPEDTFGP DPTMIRANCL 200
    VQTTEWSACS KTCGMGISTR VTNDNAFCRL EKQSRLCMVR PCEADLEENI 250
    KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 300
    LPVEFKCPDG EVMKKSMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA 349
    Length:349
    Mass (Da):37,924
    Last modified:February 11, 2002 - v2
    Checksum:i5FFC8EE83EFB4F99
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281D → DC in AAB66596. 1 PublicationCurated
    Sequence conflicti58 – 581Missing in AAB66596. 1 PublicationCurated
    Sequence conflicti88 – 881A → T in AAB66596. 1 PublicationCurated
    Sequence conflicti103 – 1042CV → YI in AAB66596. 1 PublicationCurated
    Sequence conflicti166 – 1694CDEP → SRDE in AAB66596. 1 PublicationCurated
    Sequence conflicti184 – 1841P → L in AAB66596. 1 PublicationCurated
    Sequence conflicti200 – 2001L → Q in AAB66596. 1 PublicationCurated
    Sequence conflicti209 – 2091C → Y in AAB66596. 1 PublicationCurated
    Sequence conflicti269 – 2691E → Q in AAB66596. 1 PublicationCurated
    Sequence conflicti284 – 2841C → F in AAB66596. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000137 mRNA. Translation: AAB66596.1.
    AF309555 Genomic DNA. Translation: AAG30290.1.
    BC113279 mRNA. Translation: AAI13280.1.
    RefSeqiNP_776455.1. NM_174030.2.
    UniGeneiBt.5240.

    Genome annotation databases

    EnsembliENSBTAT00000008357; ENSBTAP00000008357; ENSBTAG00000006367.
    GeneIDi281103.
    KEGGibta:281103.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000137 mRNA. Translation: AAB66596.1 .
    AF309555 Genomic DNA. Translation: AAG30290.1 .
    BC113279 mRNA. Translation: AAI13280.1 .
    RefSeqi NP_776455.1. NM_174030.2.
    UniGenei Bt.5240.

    3D structure databases

    ProteinModelPortali O18739.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O18739.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000008357 ; ENSBTAP00000008357 ; ENSBTAG00000006367 .
    GeneIDi 281103.
    KEGGi bta:281103.

    Organism-specific databases

    CTDi 1490.

    Phylogenomic databases

    eggNOGi NOG72934.
    GeneTreei ENSGT00750000117442.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi O18739.
    KOi K06827.
    OMAi KTYRAKF.
    OrthoDBi EOG7N8ZXB.
    TreeFami TF326070.

    Enzyme and pathway databases

    Reactomei REACT_207237. PPARA activates gene expression.
    REACT_223100. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

    Miscellaneous databases

    NextBioi 20805175.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bos taurus connective tissue growth factor."
      Liliensiek B., Lin Z., Fotsis T., Schimanski M., Bierhaus A., Kanitz M., Kauffmann G., Schweigerer L., Ziegler R., Nawroth P.P.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Aorta.
    2. "Bovine connective tissue growth factor, organization of the chromosomal gene and demonstration of promoter activity."
      Mathahs M., Schwitters C., Hove M., Rupp S., Erondu N.E.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Uterus.

    Entry informationi

    Entry nameiCTGF_BOVIN
    AccessioniPrimary (citable) accession number: O18739
    Secondary accession number(s): Q2HJ71, Q9GL71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 11, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3