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O18739 (CTGF_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Connective tissue growth factor
Alternative name(s):
CCN family member 2
Gene names
Name:CTGF
Synonyms:CCN2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes By similarity. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells By similarity. Enhances fibroblast growth factor-induced DNA synthesis By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity. Secreted By similarity.

Sequence similarities

Belongs to the CCN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Biological processCell adhesion
DNA synthesis
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   LigandHeparin-binding
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

angiogenesis

Inferred from electronic annotation. Source: Ensembl

cartilage condensation

Inferred from electronic annotation. Source: Ensembl

cell differentiation

Inferred from electronic annotation. Source: Ensembl

cell migration

Inferred from electronic annotation. Source: Ensembl

cell-matrix adhesion

Inferred from electronic annotation. Source: Ensembl

chondrocyte proliferation

Inferred from electronic annotation. Source: Ensembl

fibroblast growth factor receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

integrin-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

lung development

Inferred from electronic annotation. Source: Ensembl

negative regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

ossification

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of JNK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of stress fiber assembly

Inferred from electronic annotation. Source: Ensembl

reactive oxygen species metabolic process

Inferred from electronic annotation. Source: Ensembl

regulation of cell growth

Inferred from electronic annotation. Source: InterPro

regulation of chondrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 349323Connective tissue growth factor
PRO_0000014401

Regions

Domain27 – 9872IGFBP N-terminal
Domain101 – 16767VWFC
Domain198 – 24346TSP type-1
Domain256 – 33075CTCK
Region247 – 349103Heparin-binding By similarity

Amino acid modifications

Disulfide bond256 ↔ 293 By similarity
Disulfide bond273 ↔ 307 By similarity
Disulfide bond284 ↔ 323 By similarity
Disulfide bond287 ↔ 325 By similarity
Disulfide bond292 ↔ 329 By similarity

Experimental info

Sequence conflict281D → DC in AAB66596. Ref.1
Sequence conflict581Missing in AAB66596. Ref.1
Sequence conflict881A → T in AAB66596. Ref.1
Sequence conflict103 – 1042CV → YI in AAB66596. Ref.1
Sequence conflict166 – 1694CDEP → SRDE in AAB66596. Ref.1
Sequence conflict1841P → L in AAB66596. Ref.1
Sequence conflict2001L → Q in AAB66596. Ref.1
Sequence conflict2091C → Y in AAB66596. Ref.1
Sequence conflict2691E → Q in AAB66596. Ref.1
Sequence conflict2841C → F in AAB66596. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O18739 [UniParc].

Last modified February 11, 2002. Version 2.
Checksum: 5FFC8EE83EFB4F99

FASTA34937,924
        10         20         30         40         50         60 
MSATGLGPVR CAFVLLLALC SRPASSQDCS APCQCPAGPA PRCPAGVSLV LDGCGCCRVC 

        70         80         90        100        110        120 
AKQLSELCTE RDPCDPHKGL FCDFGSPANR KIGVCTAKDG APCVFGGTVY QSGESFQSSC 

       130        140        150        160        170        180 
KYQCTCLDGS VGCVPLCSVD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK EHTVVGPALA 

       190        200        210        220        230        240 
AYRPEDTFGP DPTMIRANCL VQTTEWSACS KTCGMGISTR VTNDNAFCRL EKQSRLCMVR 

       250        260        270        280        290        300 
PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 

       310        320        330        340 
LPVEFKCPDG EVMKKSMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA 

« Hide

References

« Hide 'large scale' references
[1]"Bos taurus connective tissue growth factor."
Liliensiek B., Lin Z., Fotsis T., Schimanski M., Bierhaus A., Kanitz M., Kauffmann G., Schweigerer L., Ziegler R., Nawroth P.P.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Aorta.
[2]"Bovine connective tissue growth factor, organization of the chromosomal gene and demonstration of promoter activity."
Mathahs M., Schwitters C., Hove M., Rupp S., Erondu N.E.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF000137 mRNA. Translation: AAB66596.1.
AF309555 Genomic DNA. Translation: AAG30290.1.
BC113279 mRNA. Translation: AAI13280.1.
RefSeqNP_776455.1. NM_174030.2.
UniGeneBt.5240.

3D structure databases

ProteinModelPortalO18739.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO18739.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000008357; ENSBTAP00000008357; ENSBTAG00000006367.
GeneID281103.
KEGGbta:281103.

Organism-specific databases

CTD1490.

Phylogenomic databases

eggNOGNOG72934.
GeneTreeENSGT00750000117442.
HOGENOMHOG000231462.
HOVERGENHBG000635.
InParanoidO18739.
KOK06827.
OMAKTYRAKF.
OrthoDBEOG7N8ZXB.
TreeFamTF326070.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805175.

Entry information

Entry nameCTGF_BOVIN
AccessionPrimary (citable) accession number: O18739
Secondary accession number(s): Q2HJ71, Q9GL71
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 11, 2002
Last modified: April 16, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families