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O18739

- CTGF_BOVIN

UniProt

O18739 - CTGF_BOVIN

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Protein
Connective tissue growth factor
Gene
CTGF, CCN2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes By similarity. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells By similarity. Enhances fibroblast growth factor-induced DNA synthesis By similarity.

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. angiogenesis Source: Ensembl
  3. cartilage condensation Source: Ensembl
  4. cell differentiation Source: Ensembl
  5. cell migration Source: Ensembl
  6. cell-matrix adhesion Source: Ensembl
  7. chondrocyte proliferation Source: Ensembl
  8. fibroblast growth factor receptor signaling pathway Source: Ensembl
  9. integrin-mediated signaling pathway Source: Ensembl
  10. lung development Source: Ensembl
  11. negative regulation of gene expression Source: Ensembl
  12. ossification Source: Ensembl
  13. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  14. positive regulation of JNK cascade Source: Ensembl
  15. positive regulation of cell differentiation Source: Ensembl
  16. positive regulation of stress fiber assembly Source: Ensembl
  17. reactive oxygen species metabolic process Source: Ensembl
  18. regulation of cell growth Source: InterPro
  19. regulation of chondrocyte differentiation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, DNA synthesis

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_207237. PPARA activates gene expression.
REACT_223100. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Connective tissue growth factor
Alternative name(s):
CCN family member 2
Gene namesi
Name:CTGF
Synonyms:CCN2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 9

Subcellular locationi

Secretedextracellular spaceextracellular matrix By similarity. Secreted By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 349323Connective tissue growth factor
PRO_0000014401Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi256 ↔ 293 By similarity
Disulfide bondi273 ↔ 307 By similarity
Disulfide bondi284 ↔ 323 By similarity
Disulfide bondi287 ↔ 325 By similarity
Disulfide bondi292 ↔ 329 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO18739.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliO18739.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 9872IGFBP N-terminal
Add
BLAST
Domaini101 – 16767VWFC
Add
BLAST
Domaini198 – 24346TSP type-1
Add
BLAST
Domaini256 – 33075CTCK
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni247 – 349103Heparin-binding By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the CCN family.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72934.
GeneTreeiENSGT00750000117442.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiO18739.
KOiK06827.
OMAiKTYRAKF.
OrthoDBiEOG7N8ZXB.
TreeFamiTF326070.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O18739-1 [UniParc]FASTAAdd to Basket

« Hide

MSATGLGPVR CAFVLLLALC SRPASSQDCS APCQCPAGPA PRCPAGVSLV    50
LDGCGCCRVC AKQLSELCTE RDPCDPHKGL FCDFGSPANR KIGVCTAKDG 100
APCVFGGTVY QSGESFQSSC KYQCTCLDGS VGCVPLCSVD VRLPSPDCPF 150
PRRVKLPGKC CEEWVCDEPK EHTVVGPALA AYRPEDTFGP DPTMIRANCL 200
VQTTEWSACS KTCGMGISTR VTNDNAFCRL EKQSRLCMVR PCEADLEENI 250
KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 300
LPVEFKCPDG EVMKKSMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA 349
Length:349
Mass (Da):37,924
Last modified:February 11, 2002 - v2
Checksum:i5FFC8EE83EFB4F99
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281D → DC in AAB66596. 1 Publication
Sequence conflicti58 – 581Missing in AAB66596. 1 Publication
Sequence conflicti88 – 881A → T in AAB66596. 1 Publication
Sequence conflicti103 – 1042CV → YI in AAB66596. 1 Publication
Sequence conflicti166 – 1694CDEP → SRDE in AAB66596. 1 Publication
Sequence conflicti184 – 1841P → L in AAB66596. 1 Publication
Sequence conflicti200 – 2001L → Q in AAB66596. 1 Publication
Sequence conflicti209 – 2091C → Y in AAB66596. 1 Publication
Sequence conflicti269 – 2691E → Q in AAB66596. 1 Publication
Sequence conflicti284 – 2841C → F in AAB66596. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000137 mRNA. Translation: AAB66596.1.
AF309555 Genomic DNA. Translation: AAG30290.1.
BC113279 mRNA. Translation: AAI13280.1.
RefSeqiNP_776455.1. NM_174030.2.
UniGeneiBt.5240.

Genome annotation databases

EnsembliENSBTAT00000008357; ENSBTAP00000008357; ENSBTAG00000006367.
GeneIDi281103.
KEGGibta:281103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000137 mRNA. Translation: AAB66596.1 .
AF309555 Genomic DNA. Translation: AAG30290.1 .
BC113279 mRNA. Translation: AAI13280.1 .
RefSeqi NP_776455.1. NM_174030.2.
UniGenei Bt.5240.

3D structure databases

ProteinModelPortali O18739.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O18739.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000008357 ; ENSBTAP00000008357 ; ENSBTAG00000006367 .
GeneIDi 281103.
KEGGi bta:281103.

Organism-specific databases

CTDi 1490.

Phylogenomic databases

eggNOGi NOG72934.
GeneTreei ENSGT00750000117442.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi O18739.
KOi K06827.
OMAi KTYRAKF.
OrthoDBi EOG7N8ZXB.
TreeFami TF326070.

Enzyme and pathway databases

Reactomei REACT_207237. PPARA activates gene expression.
REACT_223100. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

Miscellaneous databases

NextBioi 20805175.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTi SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bos taurus connective tissue growth factor."
    Liliensiek B., Lin Z., Fotsis T., Schimanski M., Bierhaus A., Kanitz M., Kauffmann G., Schweigerer L., Ziegler R., Nawroth P.P.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aorta.
  2. "Bovine connective tissue growth factor, organization of the chromosomal gene and demonstration of promoter activity."
    Mathahs M., Schwitters C., Hove M., Rupp S., Erondu N.E.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiCTGF_BOVIN
AccessioniPrimary (citable) accession number: O18739
Secondary accession number(s): Q2HJ71, Q9GL71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 11, 2002
Last modified: September 3, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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