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Protein

Probable 3',5'-cyclic phosphodiesterase pde-1

Gene

pde-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei333Proton donorBy similarity1
Metal bindingi337Divalent metal cation 1By similarity1
Metal bindingi373Divalent metal cation 1By similarity1
Metal bindingi374Divalent metal cation 1By similarity1
Metal bindingi374Divalent metal cation 2By similarity1
Metal bindingi480Divalent metal cation 1By similarity1

GO - Molecular functioni

  • 3',5'-cyclic-AMP phosphodiesterase activity Source: WormBase
  • 3',5'-cyclic-GMP phosphodiesterase activity Source: WormBase
  • calmodulin binding Source: WormBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cGMP catabolic process Source: WormBase
  • chemosensory behavior Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • determination of adult lifespan Source: UniProtKB
  • microvillus organization Source: WormBase
  • negative regulation of cGMP biosynthetic process Source: UniProtKB
  • negative regulation of cGMP-mediated signaling Source: WormBase
  • negative regulation of protein kinase C signaling Source: WormBase
  • phototransduction Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • regulation of establishment of cell polarity Source: WormBase
  • response to alkaline pH Source: UniProtKB
  • response to hydrogen peroxide Source: UniProtKB
  • response to oxygen levels Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calmodulin-binding, cGMP, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-111957. Cam-PDE 1 activation.
R-CEL-418457. cGMP effects.
R-CEL-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3',5'-cyclic phosphodiesterase pde-1 (EC:3.1.4.17)
Gene namesi
Name:pde-1
ORF Names:T04D3.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiT04D3.3a; CE16340; WBGene00011433; pde-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988441 – 664Probable 3',5'-cyclic phosphodiesterase pde-1Add BLAST664

Proteomic databases

PaxDbiO18696.

Expressioni

Gene expression databases

BgeeiWBGene00011433.
ExpressionAtlasiO18696. differential.

Interactioni

Subunit structurei

Interacts with cmd-1 in the presence of Ca2+.1 Publication

GO - Molecular functioni

  • calmodulin binding Source: WormBase

Protein-protein interaction databases

STRINGi6239.T04D3.3a.

Structurei

3D structure databases

ProteinModelPortaliO18696.
SMRiO18696.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3688. Eukaryota.
ENOG410XQDD. LUCA.
GeneTreeiENSGT00760000118889.
HOGENOMiHOG000231888.
InParanoidiO18696.
KOiK13755.
OMAiHVADSQI.
OrthoDBiEOG091G04C4.
PhylomeDBiO18696.

Family and domain databases

Gene3Di1.10.1300.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18696-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRARKTSSC GCFRSAFCLL KPSTSSASEE HGDSDKKLLS VQLITPRDEE
60 70 80 90 100
EQTSSRSIKI PPLDLNGLDC KKNAVAARRA GRRRTSEGGG VRGKGHFAEV
110 120 130 140 150
VLDGLQRPVS LLRNQKEKSN SDDNCQEKEP TSPSSSRKKS YDNAPALESL
160 170 180 190 200
EKLRYILHQL NSGQLPLEDL KRNIEYAALV LETAYMDETR RICDEDDDLA
210 220 230 240 250
EVTPETVPDE VREWLAATFT RQNAGKKRDK PKFKSVANAI RTGIFFEKLF
260 270 280 290 300
RKQQVVQCPI PPEIAELMKE VCTWSFSPFQ LNEVSEGHAL KYVGFELFNR
310 320 330 340 350
YGFMDRFKVP LTALENYLSA LEVGYSKHNN PYHNVVHAAD VTQSSHFMLS
360 370 380 390 400
QTGLANSLGD LELLAVLFGA LIHDYEHTGH TNNFHIQSQS QFAMLYNDRS
410 420 430 440 450
VLENHHVSSC FRLMKEDDKN ILTHLTRDEY KELRNMVIEI VLATDMSTHF
460 470 480 490 500
MQIKTMKSML SLPEGIDKNK ALCLIVHACD ISHPAKPWNL HERWTEGVLE
510 520 530 540 550
EFFRQGDLEA SMGLPYSPLC DRHTVHVADS QIGFIDFIVE PTMVVCGELL
560 570 580 590 600
VKMVEPLVSL PPTDSLFPPS VDGGDDKSPS NALSPLPDLR NSSTSPSSIR
610 620 630 640 650
RIPLNYAGKL DIPTPWMKFL HENKAHWKER AAKEEEERKI KEAAEAEAAA
660
KQVEENKENG VTTN
Length:664
Mass (Da):74,855
Last modified:July 15, 1998 - v2
Checksum:i33436A301328201E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81114 Genomic DNA. Translation: CAB03289.1.
PIRiT24459.
RefSeqiNP_493343.1. NM_060942.3.
UniGeneiCel.16823.

Genome annotation databases

EnsemblMetazoaiT04D3.3a; T04D3.3a; WBGene00011433.
GeneIDi173200.
KEGGicel:CELE_T04D3.3.
UCSCiT04D3.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81114 Genomic DNA. Translation: CAB03289.1.
PIRiT24459.
RefSeqiNP_493343.1. NM_060942.3.
UniGeneiCel.16823.

3D structure databases

ProteinModelPortaliO18696.
SMRiO18696.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T04D3.3a.

Proteomic databases

PaxDbiO18696.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT04D3.3a; T04D3.3a; WBGene00011433.
GeneIDi173200.
KEGGicel:CELE_T04D3.3.
UCSCiT04D3.3. c. elegans.

Organism-specific databases

CTDi173200.
WormBaseiT04D3.3a; CE16340; WBGene00011433; pde-1.

Phylogenomic databases

eggNOGiKOG3688. Eukaryota.
ENOG410XQDD. LUCA.
GeneTreeiENSGT00760000118889.
HOGENOMiHOG000231888.
InParanoidiO18696.
KOiK13755.
OMAiHVADSQI.
OrthoDBiEOG091G04C4.
PhylomeDBiO18696.

Enzyme and pathway databases

ReactomeiR-CEL-111957. Cam-PDE 1 activation.
R-CEL-418457. cGMP effects.
R-CEL-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiO18696.

Gene expression databases

BgeeiWBGene00011433.
ExpressionAtlasiO18696. differential.

Family and domain databases

Gene3Di1.10.1300.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDE1_CAEEL
AccessioniPrimary (citable) accession number: O18696
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.