Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O18696 (PDE1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 3',5'-cyclic phosphodiesterase pde-1

EC=3.1.4.17
Gene names
Name:pde-1
ORF Names:T04D3.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length664 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 664664Probable 3',5'-cyclic phosphodiesterase pde-1
PRO_0000198844

Sites

Active site3331Proton donor By similarity
Metal binding3371Divalent metal cation 1 By similarity
Metal binding3731Divalent metal cation 1 By similarity
Metal binding3741Divalent metal cation 1 By similarity
Metal binding3741Divalent metal cation 2 By similarity
Metal binding4801Divalent metal cation 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
O18696 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 33436A301328201E

FASTA66474,855
        10         20         30         40         50         60 
MNRARKTSSC GCFRSAFCLL KPSTSSASEE HGDSDKKLLS VQLITPRDEE EQTSSRSIKI 

        70         80         90        100        110        120 
PPLDLNGLDC KKNAVAARRA GRRRTSEGGG VRGKGHFAEV VLDGLQRPVS LLRNQKEKSN 

       130        140        150        160        170        180 
SDDNCQEKEP TSPSSSRKKS YDNAPALESL EKLRYILHQL NSGQLPLEDL KRNIEYAALV 

       190        200        210        220        230        240 
LETAYMDETR RICDEDDDLA EVTPETVPDE VREWLAATFT RQNAGKKRDK PKFKSVANAI 

       250        260        270        280        290        300 
RTGIFFEKLF RKQQVVQCPI PPEIAELMKE VCTWSFSPFQ LNEVSEGHAL KYVGFELFNR 

       310        320        330        340        350        360 
YGFMDRFKVP LTALENYLSA LEVGYSKHNN PYHNVVHAAD VTQSSHFMLS QTGLANSLGD 

       370        380        390        400        410        420 
LELLAVLFGA LIHDYEHTGH TNNFHIQSQS QFAMLYNDRS VLENHHVSSC FRLMKEDDKN 

       430        440        450        460        470        480 
ILTHLTRDEY KELRNMVIEI VLATDMSTHF MQIKTMKSML SLPEGIDKNK ALCLIVHACD 

       490        500        510        520        530        540 
ISHPAKPWNL HERWTEGVLE EFFRQGDLEA SMGLPYSPLC DRHTVHVADS QIGFIDFIVE 

       550        560        570        580        590        600 
PTMVVCGELL VKMVEPLVSL PPTDSLFPPS VDGGDDKSPS NALSPLPDLR NSSTSPSSIR 

       610        620        630        640        650        660 
RIPLNYAGKL DIPTPWMKFL HENKAHWKER AAKEEEERKI KEAAEAEAAA KQVEENKENG 


VTTN 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z81114 Genomic DNA. Translation: CAB03289.1.
PIRT24459.
RefSeqNP_493343.1. NM_060942.3.
UniGeneCel.16823.

3D structure databases

ProteinModelPortalO18696.
SMRO18696. Positions 268-632.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbO18696.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaT04D3.3a; T04D3.3a; T04D3.3.
GeneID173200.
KEGGcel:CELE_T04D3.3.
UCSCT04D3.3. c. elegans.

Organism-specific databases

CTD173200.
WormBaseT04D3.3a; CE16340; WBGene00011433; pde-1.

Phylogenomic databases

eggNOGNOG139098.
HOGENOMHOG000231888.
InParanoidO18696.
KOK13755.
OMASTAVHNC.
OrthoDBEOG7X9G6J.
PhylomeDBO18696.

Family and domain databases

Gene3D1.10.1300.10. 2 hits.
InterProIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view]
PfamPF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00471. HDc. 1 hit.
[Graphical view]
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio878687.
PROO18696.

Entry information

Entry namePDE1_CAEEL
AccessionPrimary (citable) accession number: O18696
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 16, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase