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O18696

- PDE1_CAEEL

UniProt

O18696 - PDE1_CAEEL

Protein

Probable 3',5'-cyclic phosphodiesterase pde-1

Gene

pde-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei333 – 3331Proton donorBy similarity
    Metal bindingi337 – 3371Divalent metal cation 1By similarity
    Metal bindingi373 – 3731Divalent metal cation 1By similarity
    Metal bindingi374 – 3741Divalent metal cation 1By similarity
    Metal bindingi374 – 3741Divalent metal cation 2By similarity
    Metal bindingi480 – 4801Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-nucleotide phosphodiesterase activity Source: UniProtKB-EC
    2. calmodulin binding Source: WormBase
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of protein kinase C signaling Source: WormBase
    2. regulation of establishment of cell polarity Source: WormBase
    3. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cGMP, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 3',5'-cyclic phosphodiesterase pde-1 (EC:3.1.4.17)
    Gene namesi
    Name:pde-1
    ORF Names:T04D3.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiT04D3.3a; CE16340; WBGene00011433; pde-1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 664664Probable 3',5'-cyclic phosphodiesterase pde-1PRO_0000198844Add
    BLAST

    Proteomic databases

    PaxDbiO18696.

    Structurei

    3D structure databases

    ProteinModelPortaliO18696.
    SMRiO18696. Positions 268-632.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG139098.
    GeneTreeiENSGT00660000095451.
    HOGENOMiHOG000231888.
    InParanoidiO18696.
    KOiK13755.
    OMAiSTAVHNC.
    OrthoDBiEOG7X9G6J.
    PhylomeDBiO18696.

    Family and domain databases

    Gene3Di1.10.1300.10. 2 hits.
    InterProiIPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    IPR013706. PDEase_N.
    [Graphical view]
    PfamiPF00233. PDEase_I. 1 hit.
    PF08499. PDEase_I_N. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O18696-1 [UniParc]FASTAAdd to Basket

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    MNRARKTSSC GCFRSAFCLL KPSTSSASEE HGDSDKKLLS VQLITPRDEE    50
    EQTSSRSIKI PPLDLNGLDC KKNAVAARRA GRRRTSEGGG VRGKGHFAEV 100
    VLDGLQRPVS LLRNQKEKSN SDDNCQEKEP TSPSSSRKKS YDNAPALESL 150
    EKLRYILHQL NSGQLPLEDL KRNIEYAALV LETAYMDETR RICDEDDDLA 200
    EVTPETVPDE VREWLAATFT RQNAGKKRDK PKFKSVANAI RTGIFFEKLF 250
    RKQQVVQCPI PPEIAELMKE VCTWSFSPFQ LNEVSEGHAL KYVGFELFNR 300
    YGFMDRFKVP LTALENYLSA LEVGYSKHNN PYHNVVHAAD VTQSSHFMLS 350
    QTGLANSLGD LELLAVLFGA LIHDYEHTGH TNNFHIQSQS QFAMLYNDRS 400
    VLENHHVSSC FRLMKEDDKN ILTHLTRDEY KELRNMVIEI VLATDMSTHF 450
    MQIKTMKSML SLPEGIDKNK ALCLIVHACD ISHPAKPWNL HERWTEGVLE 500
    EFFRQGDLEA SMGLPYSPLC DRHTVHVADS QIGFIDFIVE PTMVVCGELL 550
    VKMVEPLVSL PPTDSLFPPS VDGGDDKSPS NALSPLPDLR NSSTSPSSIR 600
    RIPLNYAGKL DIPTPWMKFL HENKAHWKER AAKEEEERKI KEAAEAEAAA 650
    KQVEENKENG VTTN 664
    Length:664
    Mass (Da):74,855
    Last modified:July 15, 1998 - v2
    Checksum:i33436A301328201E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81114 Genomic DNA. Translation: CAB03289.1.
    PIRiT24459.
    RefSeqiNP_493343.1. NM_060942.3.
    UniGeneiCel.16823.

    Genome annotation databases

    EnsemblMetazoaiT04D3.3a; T04D3.3a; WBGene00011433.
    GeneIDi173200.
    KEGGicel:CELE_T04D3.3.
    UCSCiT04D3.3. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81114 Genomic DNA. Translation: CAB03289.1 .
    PIRi T24459.
    RefSeqi NP_493343.1. NM_060942.3.
    UniGenei Cel.16823.

    3D structure databases

    ProteinModelPortali O18696.
    SMRi O18696. Positions 268-632.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi O18696.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T04D3.3a ; T04D3.3a ; WBGene00011433 .
    GeneIDi 173200.
    KEGGi cel:CELE_T04D3.3.
    UCSCi T04D3.3. c. elegans.

    Organism-specific databases

    CTDi 173200.
    WormBasei T04D3.3a ; CE16340 ; WBGene00011433 ; pde-1.

    Phylogenomic databases

    eggNOGi NOG139098.
    GeneTreei ENSGT00660000095451.
    HOGENOMi HOG000231888.
    InParanoidi O18696.
    KOi K13755.
    OMAi STAVHNC.
    OrthoDBi EOG7X9G6J.
    PhylomeDBi O18696.

    Miscellaneous databases

    NextBioi 878687.
    PROi O18696.

    Family and domain databases

    Gene3Di 1.10.1300.10. 2 hits.
    InterProi IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    IPR013706. PDEase_N.
    [Graphical view ]
    Pfami PF00233. PDEase_I. 1 hit.
    PF08499. PDEase_I_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPDE1_CAEEL
    AccessioniPrimary (citable) accession number: O18696
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3