O18696 (PDE1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 3',5'-cyclic phosphodiesterase pde-1
EC=3.1.4.17

Gene names

Name:	pde-1
ORF Names:	T04D3.3

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	664 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
Cofactor	Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family.

Ontologies

Keywords
Ligand	Metal-binding cGMP
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity Inferred from electronic annotation. Source: EC calmodulin binding Inferred from physical interaction. Source: WormBase metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 664	664	Probable 3',5'-cyclic phosphodiesterase pde-1		PRO_0000198844
Sites
	Active site	333	1	Proton donor By similarity
	Metal binding	337	1	Divalent metal cation 1 By similarity
	Metal binding	373	1	Divalent metal cation 1 By similarity
	Metal binding	374	1	Divalent metal cation 1 By similarity
	Metal binding	374	1	Divalent metal cation 2 By similarity
	Metal binding	480	1	Divalent metal cation 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	O18696 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: 33436A301328201E	FASTA	664	74,855
	10 20 30 40 50 60 MNRARKTSSC GCFRSAFCLL KPSTSSASEE HGDSDKKLLS VQLITPRDEE EQTSSRSIKI 70 80 90 100 110 120 PPLDLNGLDC KKNAVAARRA GRRRTSEGGG VRGKGHFAEV VLDGLQRPVS LLRNQKEKSN 130 140 150 160 170 180 SDDNCQEKEP TSPSSSRKKS YDNAPALESL EKLRYILHQL NSGQLPLEDL KRNIEYAALV 190 200 210 220 230 240 LETAYMDETR RICDEDDDLA EVTPETVPDE VREWLAATFT RQNAGKKRDK PKFKSVANAI 250 260 270 280 290 300 RTGIFFEKLF RKQQVVQCPI PPEIAELMKE VCTWSFSPFQ LNEVSEGHAL KYVGFELFNR 310 320 330 340 350 360 YGFMDRFKVP LTALENYLSA LEVGYSKHNN PYHNVVHAAD VTQSSHFMLS QTGLANSLGD 370 380 390 400 410 420 LELLAVLFGA LIHDYEHTGH TNNFHIQSQS QFAMLYNDRS VLENHHVSSC FRLMKEDDKN 430 440 450 460 470 480 ILTHLTRDEY KELRNMVIEI VLATDMSTHF MQIKTMKSML SLPEGIDKNK ALCLIVHACD 490 500 510 520 530 540 ISHPAKPWNL HERWTEGVLE EFFRQGDLEA SMGLPYSPLC DRHTVHVADS QIGFIDFIVE 550 560 570 580 590 600 PTMVVCGELL VKMVEPLVSL PPTDSLFPPS VDGGDDKSPS NALSPLPDLR NSSTSPSSIR 610 620 630 640 650 660 RIPLNYAGKL DIPTPWMKFL HENKAHWKER AAKEEEERKI KEAAEAEAAA KQVEENKENG VTTN

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z81114 Genomic DNA. Translation: CAB03289.1.
PIR	T24459.
RefSeq	NP_493343.1. NM_060942.3.
UniGene	Cel.16823.
3D structure databases
ProteinModelPortal	O18696.
SMR	O18696. Positions 256-632.
ModBase	Search...
Protein-protein interaction databases
STRING	O18696.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	T04D3.3a; T04D3.3a; T04D3.3.
GeneID	173200.
KEGG	cel:T04D3.3.
NMPDR	fig|6239.3.peg.3508.
UCSC	T04D3.3. c. elegans.
Organism-specific databases
CTD	173200.
WormBase	T04D3.3a; CE16340; WBGene00011433; pde-1.
Phylogenomic databases
eggNOG	meNOG05180.
GeneTree	EMGT00050000002162.
InParanoid	O18696.
OMA	HSLISRF.
PhylomeDB	O18696.
Gene expression databases
ArrayExpress	O18696.
Family and domain databases
InterPro	IPR003607. Metal-dep_PHydrolase_HD_dom. IPR023088. PDEase. IPR002073. PDEase_catalytic_dom. IPR023174. PDEase_CS. IPR013706. PDEase_N. [Graphical view]
Gene3D	G3DSA:1.10.1300.10. PDEase_catalytic_dom. 2 hits.
KO	K13755.
Pfam	PF00233. PDEase_I. 1 hit. PF08499. PDEase_I_N. 1 hit. [Graphical view]
PRINTS	PR00387. PDIESTERASE1.
SMART	SM00471. HDc. 1 hit. [Graphical view]
PROSITE	PS00126. PDEASE_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	878687.

Entry information

Entry name

PDE1_CAEEL

Accession

Primary (citable) accession number: O18696

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	November 16, 2011
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project