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O18696

- PDE1_CAEEL

UniProt

O18696 - PDE1_CAEEL

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Protein

Probable 3',5'-cyclic phosphodiesterase pde-1

Gene

pde-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei333 – 3331Proton donorBy similarity
Metal bindingi337 – 3371Divalent metal cation 1By similarity
Metal bindingi373 – 3731Divalent metal cation 1By similarity
Metal bindingi374 – 3741Divalent metal cation 1By similarity
Metal bindingi374 – 3741Divalent metal cation 2By similarity
Metal bindingi480 – 4801Divalent metal cation 1By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-nucleotide phosphodiesterase activity Source: UniProtKB-EC
  2. calmodulin binding Source: WormBase
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of protein kinase C signaling Source: WormBase
  2. regulation of establishment of cell polarity Source: WormBase
  3. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3',5'-cyclic phosphodiesterase pde-1 (EC:3.1.4.17)
Gene namesi
Name:pde-1
ORF Names:T04D3.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiT04D3.3a; CE16340; WBGene00011433; pde-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 664664Probable 3',5'-cyclic phosphodiesterase pde-1PRO_0000198844Add
BLAST

Proteomic databases

PaxDbiO18696.

Expressioni

Gene expression databases

ExpressionAtlasiO18696. baseline.

Structurei

3D structure databases

ProteinModelPortaliO18696.
SMRiO18696. Positions 268-632.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG139098.
GeneTreeiENSGT00760000118889.
HOGENOMiHOG000231888.
InParanoidiO18696.
KOiK13755.
OMAiSTAVHNC.
OrthoDBiEOG7X9G6J.
PhylomeDBiO18696.

Family and domain databases

Gene3Di1.10.1300.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18696-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRARKTSSC GCFRSAFCLL KPSTSSASEE HGDSDKKLLS VQLITPRDEE
60 70 80 90 100
EQTSSRSIKI PPLDLNGLDC KKNAVAARRA GRRRTSEGGG VRGKGHFAEV
110 120 130 140 150
VLDGLQRPVS LLRNQKEKSN SDDNCQEKEP TSPSSSRKKS YDNAPALESL
160 170 180 190 200
EKLRYILHQL NSGQLPLEDL KRNIEYAALV LETAYMDETR RICDEDDDLA
210 220 230 240 250
EVTPETVPDE VREWLAATFT RQNAGKKRDK PKFKSVANAI RTGIFFEKLF
260 270 280 290 300
RKQQVVQCPI PPEIAELMKE VCTWSFSPFQ LNEVSEGHAL KYVGFELFNR
310 320 330 340 350
YGFMDRFKVP LTALENYLSA LEVGYSKHNN PYHNVVHAAD VTQSSHFMLS
360 370 380 390 400
QTGLANSLGD LELLAVLFGA LIHDYEHTGH TNNFHIQSQS QFAMLYNDRS
410 420 430 440 450
VLENHHVSSC FRLMKEDDKN ILTHLTRDEY KELRNMVIEI VLATDMSTHF
460 470 480 490 500
MQIKTMKSML SLPEGIDKNK ALCLIVHACD ISHPAKPWNL HERWTEGVLE
510 520 530 540 550
EFFRQGDLEA SMGLPYSPLC DRHTVHVADS QIGFIDFIVE PTMVVCGELL
560 570 580 590 600
VKMVEPLVSL PPTDSLFPPS VDGGDDKSPS NALSPLPDLR NSSTSPSSIR
610 620 630 640 650
RIPLNYAGKL DIPTPWMKFL HENKAHWKER AAKEEEERKI KEAAEAEAAA
660
KQVEENKENG VTTN
Length:664
Mass (Da):74,855
Last modified:July 15, 1998 - v2
Checksum:i33436A301328201E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z81114 Genomic DNA. Translation: CAB03289.1.
PIRiT24459.
RefSeqiNP_493343.1. NM_060942.3.
UniGeneiCel.16823.

Genome annotation databases

EnsemblMetazoaiT04D3.3a; T04D3.3a; WBGene00011433.
GeneIDi173200.
KEGGicel:CELE_T04D3.3.
UCSCiT04D3.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z81114 Genomic DNA. Translation: CAB03289.1 .
PIRi T24459.
RefSeqi NP_493343.1. NM_060942.3.
UniGenei Cel.16823.

3D structure databases

ProteinModelPortali O18696.
SMRi O18696. Positions 268-632.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi O18696.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T04D3.3a ; T04D3.3a ; WBGene00011433 .
GeneIDi 173200.
KEGGi cel:CELE_T04D3.3.
UCSCi T04D3.3. c. elegans.

Organism-specific databases

CTDi 173200.
WormBasei T04D3.3a ; CE16340 ; WBGene00011433 ; pde-1.

Phylogenomic databases

eggNOGi NOG139098.
GeneTreei ENSGT00760000118889.
HOGENOMi HOG000231888.
InParanoidi O18696.
KOi K13755.
OMAi STAVHNC.
OrthoDBi EOG7X9G6J.
PhylomeDBi O18696.

Miscellaneous databases

NextBioi 878687.
PROi O18696.

Gene expression databases

ExpressionAtlasi O18696. baseline.

Family and domain databases

Gene3Di 1.10.1300.10. 2 hits.
InterProi IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view ]
Pfami PF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPDE1_CAEEL
AccessioniPrimary (citable) accession number: O18696
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3