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Protein

Tubulin alpha chain

Gene

tba-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: WormBase
  • establishment of mitotic spindle orientation Source: WormBase
  • regulation of cytokinesis Source: WormBase

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin alpha chainUniRule annotation
Gene namesi
Name:tba-1Imported
ORF Names:CELE_F26E4.8Imported, F26E4.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF26E4.8a ; CE09692 ; WBGene00006528 ; tba-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonSAAS annotation, MicrotubuleUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

EPDiO18688

Expressioni

Gene expression databases

BgeeiWBGene00006528
ExpressionAtlasiO18688 baseline and differential

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotationSAAS annotation

Protein-protein interaction databases

DIPiDIP-25114N
IntActiO18688, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliO18688
SMRiO18688
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 244TubulinInterPro annotationAdd BLAST198
Domaini246 – 391Tubulin_CInterPro annotationAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili416 – 436Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1376 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00760000119060
HOGENOMiHOG000165711
PhylomeDBiO18688

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002452 Alpha_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01162 ALPHATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

O18688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREVISIHVG QAGVQIGNAC WELYCLEHGI QPDGTMPSDQ QADGESFTTF
60 70 80 90 100
FSDTGNGRYV PRSIFVDLEP TVVDEIRTGT YKKLFHPEQM ITGKEDAANN
110 120 130 140 150
YARGHYTVGK ELIDTVLDRI RRLADNCSGL QGFFVFHSFG GGTGSGFTSL
160 170 180 190 200
LMERLSVDYG KKSKLEFSIY PAPQVSTAVV EPYNSILTTH TTLEHSDCAF
210 220 230 240 250
MVDNEAIYDI CRRNLSVDRP SYTNLNRIIS QVVSSITASL RFDGALNVDL
260 270 280 290 300
NEFQTNLVPY PRIHFPLAAY TPLISADKAY HEALSVNDIT NSCFEPANQM
310 320 330 340 350
VKCDPRHGKY MAVCLLYRGD VVPKDVNTAI AAIKTKRTIQ FVDWCPTGFK
360 370 380 390 400
VGINYQPPTV VPGGDLAKVP RAVCMLSNTT AIAEAWSRLD YKFDLMYAKR
410 420 430 440
AFVHWYVGEG MEEGEFTEAR EDLAALEKDY EEVGADSNEG GNEEEGEEY
Length:449
Mass (Da):50,009
Last modified:January 1, 1998 - v1
Checksum:i991D292EDC04BDB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB03001.1
PIRiT21415
RefSeqiNP_001251213.1, NM_001264284.1
UniGeneiCel.38859

Genome annotation databases

EnsemblMetazoaiF26E4.8a; F26E4.8a; WBGene00006528
GeneIDi172831

Similar proteinsi

Entry informationi

Entry nameiO18688_CAEEL
AccessioniPrimary (citable) accession number: O18688
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health