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Protein
Submitted name:

LD42724p

Gene

Pi3K21B

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • insulin receptor substrate binding Source: UniProtKB
  • kinase activity Source: UniProtKB-KW
  • kinase binding Source: FlyBase
  • phosphatidylinositol 3-kinase regulator activity Source: UniProtKB

GO - Biological processi

  • insulin receptor signaling pathway Source: FlyBase
  • lipid phosphorylation Source: FlyBase
  • phosphatidylinositol phosphorylation Source: FlyBase
  • positive regulation of cell size Source: FlyBase
  • positive regulation of growth Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • regulation of cell proliferation Source: FlyBase
  • regulation of cell size Source: FlyBase
  • regulation of organ growth Source: FlyBase

Keywordsi

Molecular functionKinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-DME-109704. PI3K Cascade.
R-DME-114604. GPVI-mediated activation cascade.
R-DME-1250342. PI3K events in ERBB4 signaling.
R-DME-1257604. PIP3 activates AKT signaling.
R-DME-1266695. Interleukin-7 signaling.
R-DME-1433557. Signaling by SCF-KIT.
R-DME-1660499. Synthesis of PIPs at the plasma membrane.
R-DME-180292. GAB1 signalosome.
R-DME-194840. Rho GTPase cycle.
R-DME-1963642. PI3K events in ERBB2 signaling.
R-DME-198203. PI3K/AKT activation.
R-DME-210993. Tie2 Signaling.
R-DME-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-DME-416476. G alpha (q) signalling events.
R-DME-416482. G alpha (12/13) signalling events.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-5654689. PI-3K cascade:FGFR1.
R-DME-5654695. PI-3K cascade:FGFR2.
R-DME-5654710. PI-3K cascade:FGFR3.
R-DME-5654720. PI-3K cascade:FGFR4.
R-DME-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-DME-912631. Regulation of signaling by CBL.
R-DME-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Submitted name:
LD42724pImported
Submitted name:
Phosphatidylinositol 3-kinase regulatory subunitImported
Submitted name:
Uncharacterized protein Pi3K21BImported
Submitted name:
p60 proteinImported
Gene namesi
Name:Pi3K21BImported
Synonyms:droPIK57Imported, p60Imported
ORF Names:CG2699Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0020622. Pi3K21B.

Subcellular locationi

Expressioni

Gene expression databases

BgeeiFBgn0020622.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • insulin receptor substrate binding Source: UniProtKB
  • kinase binding Source: FlyBase

Protein-protein interaction databases

IntActiO18683. 19 interactors.
MINTiMINT-752725.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 126SH2InterPro annotationAdd BLAST95
Domaini337 – 430SH2InterPro annotationAdd BLAST94

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili155 – 179Sequence analysisAdd BLAST25
Coiled coili231 – 255Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4637. Eukaryota.
ENOG410XP6R. LUCA.
HOGENOMiHOG000098111.
OrthoDBiEOG091G07RV.

Family and domain databases

CDDicd09930. SH2_cSH2_p85_like. 1 hit.
cd09942. SH2_nSH2_p85_like. 1 hit.
Gene3Di3.30.505.10. 2 hits.
InterProiView protein in InterPro
IPR032498. PI3K_P85_iSH2.
IPR035020. PI3kinase_P85_cSH2.
IPR035022. PI3kinase_P85_nSH2.
IPR001720. PI3kinase_P85_p55.
IPR000980. SH2.
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiView protein in Pfam
PF16454. PI3K_P85_iSH2. 1 hit.
PF00017. SH2. 2 hits.
PRINTSiPR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 2 hits.
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiView protein in PROSITE
PS50001. SH2. 2 hits.

Sequencei

Sequence statusi: Complete.

O18683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPSPLHYST MRPQAPGSLV DPNEDELRMA PWYWGRISRE EAKSILHGKP
60 70 80 90 100
DGSFLVRDAL SMKGEYTLTL MKDGCEKLIK ICHMDRKYGF IETDLFNSVV
110 120 130 140 150
EMINYYKENS LSMYNKTLDI TLSNPIVRAR EDEESQPHGD LCLLSNEFIR
160 170 180 190 200
TCQLLQNLEQ NLENKRNSFN AIREELQEKK LHQSVFGNTE KIFRNQIKLN
210 220 230 240 250
ESFMKAPADA PSTEAGGAGD GANAAASAAA NANARRSLQE HKQTLLNLLD
260 270 280 290 300
ALQAKGQVLN HYMENKKKEE LLLERQINAL KPELQILQLR KDKYIERLKG
310 320 330 340 350
FNLKDDDLKM ILQMGFDKWQ QLYETVSNQP HSNEALWLLK DAKRRNAEEM
360 370 380 390 400
LKGAPSGTFL IRARDAGHYA LSIACKNIVQ HCLIYETSTG FGFAAPYNIY
410 420 430 440 450
ATLKSLVEHY ANNSLEEHND TLTTTLRWPV LYWKNNPLQV QMIQLQEEMD
460 470 480 490 500
LEYEQAATLR PPPMMGSSAP IPTSRSREHD VVDGTGSLEA EAAPASISPS

NFSTSQ
Length:506
Mass (Da):57,428
Last modified:July 5, 2004 - v3
Checksum:iA9DE8879EED07738
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY060429 mRNA. Translation: AAL25468.1.
Y11143 mRNA. Translation: CAA72030.1.
Y12498 mRNA. Translation: CAA73100.1.
FR870212 Genomic DNA. Translation: CCB63170.1.
FR870213 Genomic DNA. Translation: CCB63171.1.
FR870214 Genomic DNA. Translation: CCB63172.1.
FR870215 Genomic DNA. Translation: CCB63173.1.
FR870216 Genomic DNA. Translation: CCB63174.1.
FR870217 Genomic DNA. Translation: CCB63175.1.
FR870218 Genomic DNA. Translation: CCB63176.1.
FR870219 Genomic DNA. Translation: CCB63177.1.
FR870220 Genomic DNA. Translation: CCB63178.1.
FR870221 Genomic DNA. Translation: CCB63179.1.
FR870222 Genomic DNA. Translation: CCB63180.1.
FR870223 Genomic DNA. Translation: CCB63181.1.

Genome annotation databases

EnsemblMetazoaiFBtr0331208; FBpp0303635; FBgn0020622.
UCSCiCG2699-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiO18683_DROME
AccessioniPrimary (citable) accession number: O18683
Secondary accession number(s): Q95SY4, Q9VPN6
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)