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Protein
Submitted name:

LD42724p

Gene

Pi3K21B

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • insulin receptor substrate binding Source: UniProtKB
  • kinase activity Source: UniProtKB-KW
  • kinase binding Source: FlyBase
  • phosphatidylinositol 3-kinase regulator activity Source: UniProtKB

GO - Biological processi

  • phosphatidylinositol phosphorylation Source: FlyBase
  • regulation of cell proliferation Source: FlyBase
  • regulation of cell size Source: FlyBase

Keywordsi

Molecular functionKinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-DME-109704 PI3K Cascade
R-DME-110478 Insulin signaling pathway
R-DME-114604 GPVI-mediated activation cascade
R-DME-1257604 PIP3 activates AKT signaling
R-DME-1433557 Signaling by SCF-KIT
R-DME-1660499 Synthesis of PIPs at the plasma membrane
R-DME-180292 GAB1 signalosome
R-DME-194840 Rho GTPase cycle
R-DME-1963642 PI3K events in ERBB2 signaling
R-DME-198203 PI3K/AKT activation
R-DME-210993 Tie2 Signaling
R-DME-4420097 VEGFA-VEGFR2 Pathway
R-DME-5654689 PI-3K cascade:FGFR1
R-DME-5654695 PI-3K cascade:FGFR2
R-DME-5654710 PI-3K cascade:FGFR3
R-DME-5654720 PI-3K cascade:FGFR4
R-DME-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-912631 Regulation of signaling by CBL
R-DME-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Names & Taxonomyi

Protein namesi
Submitted name:
LD42724pImported
Submitted name:
Phosphatidylinositol 3-kinase regulatory subunitImported
Submitted name:
p60 proteinImported
Gene namesi
Name:Pi3K21BImported
Synonyms:droPIK57Imported, p60Imported
ORF Names:CG2699Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0020622 Pi3K21B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiO18683

Expressioni

Gene expression databases

BgeeiFBgn0020622
ExpressionAtlasiO18683 baseline and differential

Interactioni

GO - Molecular functioni

  • insulin receptor substrate binding Source: UniProtKB
  • kinase binding Source: FlyBase

Protein-protein interaction databases

IntActiO18683, 13 interactors

Structurei

3D structure databases

SMRiO18683
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 126SH2InterPro annotationAdd BLAST95
Domaini337 – 430SH2InterPro annotationAdd BLAST94

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili155 – 179Sequence analysisAdd BLAST25
Coiled coili231 – 255Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4637 Eukaryota
ENOG410XP6R LUCA
HOGENOMiHOG000098111
OrthoDBiEOG091G07RV

Family and domain databases

CDDicd09930 SH2_cSH2_p85_like, 1 hit
cd09942 SH2_nSH2_p85_like, 1 hit
Gene3Di3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR032498 PI3K_P85_iSH2
IPR035020 PI3kinase_P85_cSH2
IPR035022 PI3kinase_P85_nSH2
IPR001720 PI3kinase_P85_p55
IPR000980 SH2
IPR036860 SH2_dom_sf
PANTHERiPTHR10155 PTHR10155, 1 hit
PfamiView protein in Pfam
PF16454 PI3K_P85_iSH2, 1 hit
PF00017 SH2, 2 hits
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 2 hits
SUPFAMiSSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50001 SH2, 2 hits

Sequencei

Sequence statusi: Complete.

O18683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPSPLHYST MRPQAPGSLV DPNEDELRMA PWYWGRISRE EAKSILHGKP
60 70 80 90 100
DGSFLVRDAL SMKGEYTLTL MKDGCEKLIK ICHMDRKYGF IETDLFNSVV
110 120 130 140 150
EMINYYKENS LSMYNKTLDI TLSNPIVRAR EDEESQPHGD LCLLSNEFIR
160 170 180 190 200
TCQLLQNLEQ NLENKRNSFN AIREELQEKK LHQSVFGNTE KIFRNQIKLN
210 220 230 240 250
ESFMKAPADA PSTEAGGAGD GANAAASAAA NANARRSLQE HKQTLLNLLD
260 270 280 290 300
ALQAKGQVLN HYMENKKKEE LLLERQINAL KPELQILQLR KDKYIERLKG
310 320 330 340 350
FNLKDDDLKM ILQMGFDKWQ QLYETVSNQP HSNEALWLLK DAKRRNAEEM
360 370 380 390 400
LKGAPSGTFL IRARDAGHYA LSIACKNIVQ HCLIYETSTG FGFAAPYNIY
410 420 430 440 450
ATLKSLVEHY ANNSLEEHND TLTTTLRWPV LYWKNNPLQV QMIQLQEEMD
460 470 480 490 500
LEYEQAATLR PPPMMGSSAP IPTSRSREHD VVDGTGSLEA EAAPASISPS

NFSTSQ
Length:506
Mass (Da):57,428
Last modified:July 5, 2004 - v3
Checksum:iA9DE8879EED07738
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY060429 mRNA Translation: AAL25468.1
Y11143 mRNA Translation: CAA72030.1
Y12498 mRNA Translation: CAA73100.1
FR870212 Genomic DNA Translation: CCB63170.1
FR870213 Genomic DNA Translation: CCB63171.1
FR870214 Genomic DNA Translation: CCB63172.1
FR870215 Genomic DNA Translation: CCB63173.1
FR870216 Genomic DNA Translation: CCB63174.1
FR870217 Genomic DNA Translation: CCB63175.1
FR870218 Genomic DNA Translation: CCB63176.1
FR870219 Genomic DNA Translation: CCB63177.1
FR870220 Genomic DNA Translation: CCB63178.1
FR870221 Genomic DNA Translation: CCB63179.1
FR870222 Genomic DNA Translation: CCB63180.1
FR870223 Genomic DNA Translation: CCB63181.1

Genome annotation databases

EnsemblMetazoaiFBtr0331205; FBpp0303632; FBgn0020622
UCSCiCG2699-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiO18683_DROME
AccessioniPrimary (citable) accession number: O18683
Secondary accession number(s): Q95SY4, Q9VPN6
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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