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Protein
Submitted name:

LD42724p

Gene

Pi3K21B

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • insulin receptor substrate binding Source: UniProtKB
  • kinase activity Source: UniProtKB-KW
  • kinase binding Source: FlyBase
  • phosphatidylinositol 3-kinase regulator activity Source: UniProtKB

GO - Biological processi

  • insulin receptor signaling pathway Source: FlyBase
  • lipid phosphorylation Source: FlyBase
  • phosphatidylinositol phosphorylation Source: FlyBase
  • positive regulation of cell size Source: FlyBase
  • positive regulation of growth Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • regulation of cell proliferation Source: FlyBase
  • regulation of cell size Source: FlyBase
  • regulation of organ growth Source: FlyBase
  • regulation of phosphatidylinositol 3-kinase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-DME-109704. PI3K Cascade.
R-DME-114604. GPVI-mediated activation cascade.
R-DME-1257604. PIP3 activates AKT signaling.
R-DME-1660499. Synthesis of PIPs at the plasma membrane.
R-DME-180292. GAB1 signalosome.
R-DME-194840. Rho GTPase cycle.
R-DME-1963642. PI3K events in ERBB2 signaling.
R-DME-198203. PI3K/AKT activation.
R-DME-210993. Tie2 Signaling.
R-DME-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-5654689. PI-3K cascade:FGFR1.
R-DME-5654695. PI-3K cascade:FGFR2.
R-DME-5654710. PI-3K cascade:FGFR3.
R-DME-5654720. PI-3K cascade:FGFR4.
R-DME-912631. Regulation of signaling by CBL.
R-DME-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Submitted name:
LD42724pImported
Submitted name:
P60 proteinImported
Submitted name:
Phosphatidylinositol 3-kinase regulatory subunitImported
Submitted name:
Putative uncharacterized protein Pi3K21BImported
Gene namesi
Name:Pi3K21BImported
Synonyms:droPIK57Imported, p60Imported
ORF Names:CG2699Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0020622. Pi3K21B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO18683.

Expressioni

Gene expression databases

ExpressionAtlasiO18683. differential.

Interactioni

GO - Molecular functioni

  • insulin receptor substrate binding Source: UniProtKB
  • kinase binding Source: FlyBase

Protein-protein interaction databases

IntActiO18683. 13 interactions.
MINTiMINT-752725.
STRINGi7227.FBpp0303635.

Structurei

3D structure databases

ProteinModelPortaliO18683.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 12695SH2InterPro annotationAdd
BLAST
Domaini337 – 43094SH2InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili155 – 17925Sequence analysisAdd
BLAST
Coiled coili231 – 25525Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4637. Eukaryota.
ENOG410XP6R. LUCA.
HOGENOMiHOG000098111.
OrthoDBiEOG7BP831.
PhylomeDBiO18683.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiIPR032498. PI3K_P85_iSH2.
IPR001720. PI3kinase_P85.
IPR000980. SH2.
[Graphical view]
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiPF16454. PI3K_P85_iSH2. 1 hit.
PF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPSPLHYST MRPQAPGSLV DPNEDELRMA PWYWGRISRE EAKSILHGKP
60 70 80 90 100
DGSFLVRDAL SMKGEYTLTL MKDGCEKLIK ICHMDRKYGF IETDLFNSVV
110 120 130 140 150
EMINYYKENS LSMYNKTLDI TLSNPIVRAR EDEESQPHGD LCLLSNEFIR
160 170 180 190 200
TCQLLQNLEQ NLENKRNSFN AIREELQEKK LHQSVFGNTE KIFRNQIKLN
210 220 230 240 250
ESFMKAPADA PSTEAGGAGD GANAAASAAA NANARRSLQE HKQTLLNLLD
260 270 280 290 300
ALQAKGQVLN HYMENKKKEE LLLERQINAL KPELQILQLR KDKYIERLKG
310 320 330 340 350
FNLKDDDLKM ILQMGFDKWQ QLYETVSNQP HSNEALWLLK DAKRRNAEEM
360 370 380 390 400
LKGAPSGTFL IRARDAGHYA LSIACKNIVQ HCLIYETSTG FGFAAPYNIY
410 420 430 440 450
ATLKSLVEHY ANNSLEEHND TLTTTLRWPV LYWKNNPLQV QMIQLQEEMD
460 470 480 490 500
LEYEQAATLR PPPMMGSSAP IPTSRSREHD VVDGTGSLEA EAAPASISPS

NFSTSQ
Length:506
Mass (Da):57,428
Last modified:July 5, 2004 - v3
Checksum:iA9DE8879EED07738
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY060429 mRNA. Translation: AAL25468.1.
Y11143 mRNA. Translation: CAA72030.1.
Y12498 mRNA. Translation: CAA73100.1.
FR870212 Genomic DNA. Translation: CCB63170.1.
FR870213 Genomic DNA. Translation: CCB63171.1.
FR870214 Genomic DNA. Translation: CCB63172.1.
FR870215 Genomic DNA. Translation: CCB63173.1.
FR870216 Genomic DNA. Translation: CCB63174.1.
FR870217 Genomic DNA. Translation: CCB63175.1.
FR870218 Genomic DNA. Translation: CCB63176.1.
FR870219 Genomic DNA. Translation: CCB63177.1.
FR870220 Genomic DNA. Translation: CCB63178.1.
FR870221 Genomic DNA. Translation: CCB63179.1.
FR870222 Genomic DNA. Translation: CCB63180.1.
FR870223 Genomic DNA. Translation: CCB63181.1.

Genome annotation databases

UCSCiCG2699-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY060429 mRNA. Translation: AAL25468.1.
Y11143 mRNA. Translation: CAA72030.1.
Y12498 mRNA. Translation: CAA73100.1.
FR870212 Genomic DNA. Translation: CCB63170.1.
FR870213 Genomic DNA. Translation: CCB63171.1.
FR870214 Genomic DNA. Translation: CCB63172.1.
FR870215 Genomic DNA. Translation: CCB63173.1.
FR870216 Genomic DNA. Translation: CCB63174.1.
FR870217 Genomic DNA. Translation: CCB63175.1.
FR870218 Genomic DNA. Translation: CCB63176.1.
FR870219 Genomic DNA. Translation: CCB63177.1.
FR870220 Genomic DNA. Translation: CCB63178.1.
FR870221 Genomic DNA. Translation: CCB63179.1.
FR870222 Genomic DNA. Translation: CCB63180.1.
FR870223 Genomic DNA. Translation: CCB63181.1.

3D structure databases

ProteinModelPortaliO18683.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO18683. 13 interactions.
MINTiMINT-752725.
STRINGi7227.FBpp0303635.

Proteomic databases

PaxDbiO18683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiCG2699-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0020622. Pi3K21B.

Phylogenomic databases

eggNOGiKOG4637. Eukaryota.
ENOG410XP6R. LUCA.
HOGENOMiHOG000098111.
OrthoDBiEOG7BP831.
PhylomeDBiO18683.

Enzyme and pathway databases

ReactomeiR-DME-109704. PI3K Cascade.
R-DME-114604. GPVI-mediated activation cascade.
R-DME-1257604. PIP3 activates AKT signaling.
R-DME-1660499. Synthesis of PIPs at the plasma membrane.
R-DME-180292. GAB1 signalosome.
R-DME-194840. Rho GTPase cycle.
R-DME-1963642. PI3K events in ERBB2 signaling.
R-DME-198203. PI3K/AKT activation.
R-DME-210993. Tie2 Signaling.
R-DME-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-5654689. PI-3K cascade:FGFR1.
R-DME-5654695. PI-3K cascade:FGFR2.
R-DME-5654710. PI-3K cascade:FGFR3.
R-DME-5654720. PI-3K cascade:FGFR4.
R-DME-912631. Regulation of signaling by CBL.
R-DME-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Miscellaneous databases

NextBioi782404.

Gene expression databases

ExpressionAtlasiO18683. differential.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiIPR032498. PI3K_P85_iSH2.
IPR001720. PI3kinase_P85.
IPR000980. SH2.
[Graphical view]
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiPF16454. PI3K_P85_iSH2. 1 hit.
PF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of the droPIK57 gene encoding a new regulatory subunit of phosphatidylinositol 3-kinase from Drosophila melanogaster."
    Albert S., Twardzik T., Heisenberg M., Schneuwly S.
    Gene 198:181-189(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeadImported.
  2. "p60 is an adaptor for the Drosophila phosphoinositide 3-kinase, Dp110."
    Weinkove D., Leevers S.J., MacDougall L.K., Waterfield M.D.
    J. Biol. Chem. 272:14606-14610(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Eye imaginal discImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  4. "Molecular population genetics of the insulin/TOR signal transduction pathway: A network-level analysis in Drosophila melanogaster."
    Alvarez-Ponce D., Guirao-Rico S., Orengo D.J., Segarra C., Rozas J., Aguade M.
    Mol. Biol. Evol. 29:123-132(2012)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CN01_10IIImported, CN03_2IIImported, CN13_2IIImported, CN14_8IIImported, CN18_3IIImported, CN21_9IIImported, CN28_6IIImported, CN29_3IIImported, CN41_4IIImported, CN43_1IIImported, CN45_7IIImported and CN46_2IIImported.

Entry informationi

Entry nameiO18683_DROME
AccessioniPrimary (citable) accession number: O18683
Secondary accession number(s): Q95SY4, Q9VPN6
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.