O18680 (O18680_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Aminolevulinate synthase EMBL AAF47119.1
EC=2.3.1.37 EMBL AAF47119.1
EC=2.6.-.- EMBL AAF47119.1

Submitted name:
Delta-aminolevulinate synthase EMBL CAA74914.1
EC=2.3.1.37 EMBL CAA74914.1
Submitted name:
FI09607p EMBL ACH92497.1

Gene names

Name:	Alas EMBL AAF47119.1 FlyBase FBgn0020764
Synonyms:	alas EMBL CAA74914.1, Alas-RA EMBL ACH92497.1
ORF Names:	CG3017 FlyBase FBgn0020764, Dmel_CG3017 EMBL AAF47119.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	539 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Acyltransferase EMBL AAF47119.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tetrapyrrole biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	5-aminolevulinate synthase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring nitrogenous groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O18680 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: FED46ADBED225D9A	FASTA	539	58,752
	10 20 30 40 50 60 MQCPFLNRFT ASFIRNYAET LCQSYGSHCP VVGKTLVSGE KKLSLVAASV TRSHSTGANA 70 80 90 100 110 120 HANAGGPATA NATAPVSAPA SADPGKASAK ETFPYERFFN EQIMKKKRDH SYRVFKKVNR 130 140 150 160 170 180 LAGDGLFPHA LEYSERTEKP ITVWCSNDYL GMSAHPGVKR AVQDALNRHG SGAGGTRNIS 190 200 210 220 230 240 GNSLHHERLE SKLAELHQKE AALLFTSCFV ANDSTLFTLA KLLPGCEIFS DAGNHASMIM 250 260 270 280 290 300 GIRNSGVPKH IFRHNDVDHL HQLLKQTDKS VPKIVAFETV HSMTGAICPL EELLDVAHEH 310 320 330 340 350 360 GAITFIDEVH AVGLYGDHGA GVGERDGVLH KMDIISGTLG KAFGNIGGYI AGTHNLVDMI 370 380 390 400 410 420 RSYAAGFIFT TSLPPTVLCG ALEAVNILAS EEGRQLRHLH QRNVSYLKSL LKREGFPVEE 430 440 450 460 470 480 TPSHIIPIKI GDPLKSSQIS NVLIEQFGHY LQSINYPTVA RGQEKLRLAP TPFHTFEMMN 490 500 510 520 530 ALVTDLKKVW EMVDLSTNVP LSPNACMFCN SESCWHQDTS PDLECGIPNC PRLEISLAA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Structure and regulated expression of the delta-aminolevulinate synthase gene from Drosophila melanogaster." Ruiz de Mena I., Fernandez-Moreno M.A., Bornstein B., Kaguni L.S., Garesse R. J. Biol. Chem. 274:37321-37328(1999) [PubMed: 10601299] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[4]	Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S. Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013599 Genomic DNA. Translation: AAF47119.1. BT044432 mRNA. Translation: ACH92497.1. Y14576 mRNA. Translation: CAA74914.1. Y14577 Genomic DNA. Translation: CAA74915.1.
RefSeq	NP_477281.1. NM_057933.3.
UniGene	Dm.4865.
3D structure databases
HSSP	HSSP built from PDB template 1FC4 based on UniProtKB P07912.
ProteinModelPortal	O18680.
SMR	O18680. Positions 94-492.
ModBase	Search...
Protein-protein interaction databases
IntAct	O18680. 3 interactions.
MINT	MINT-816188.
STRING	O18680.
Proteomic databases
PRIDE	O18680.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0072151; FBpp0072060; FBgn0020764.
GeneID	37815.
KEGG	dme:Dmel_CG3017.
NMPDR	fig|7227.3.peg.7198.
UCSC	CG3017-RA. d. melanogaster.
Organism-specific databases
CTD	37815.
FlyBase	FBgn0020764. Alas.
Phylogenomic databases
eggNOG	inNOG06607.
InParanoid	O18680.
OMA	HLKESNE.
OrthoDB	EOG45HQCK.
PhylomeDB	O18680.
Gene expression databases
Bgee	O18680.
Family and domain databases
InterPro	IPR010961. 4pyrrol_synth_NH2levulA_synth. IPR004839. Aminotransferase_I/II. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00643.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01821. 5aminolev_synth. 1 hit.
ProtoNet	Search...
Other
NextBio	805537.

Entry information

Entry name

O18680_DROME

Accession

Primary (citable) accession number: O18680

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)