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Protein

Guanine nucleotide-binding protein subunit beta-like protein

Gene

Rack1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to starvation Source: FlyBase
  • cuticle development Source: FlyBase
  • IRES-dependent viral translational initiation Source: FlyBase
  • locomotory behavior Source: FlyBase
  • mRNA splicing, via spliceosome Source: FlyBase
  • muscle cell cellular homeostasis Source: FlyBase
  • oogenesis Source: FlyBase
  • oviposition Source: FlyBase
  • positive regulation by host of viral genome replication Source: FlyBase
  • positive regulation of glycogen biosynthetic process Source: FlyBase
  • regulation of autophagosome size Source: FlyBase
  • wing disc development Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiO18640.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-like protein
Alternative name(s):
Receptor of activated protein kinase C homolog
Gene namesi
Name:Rack1
ORF Names:CG7111
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0020618. Rack1.

Subcellular locationi

GO - Cellular componenti

  • autophagosome Source: FlyBase
  • catalytic step 2 spliceosome Source: FlyBase
  • cytoplasm Source: FlyBase
  • cytosol Source: FlyBase
  • microtubule associated complex Source: FlyBase
  • precatalytic spliceosome Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Guanine nucleotide-binding protein subunit beta-like proteinPRO_0000127740Add
BLAST

Proteomic databases

PaxDbiO18640.
PRIDEiO18640.

Expressioni

Tissue specificityi

Highest expression in the mesodermal and endodermal lineages.1 Publication

Gene expression databases

BgeeiFBgn0020618.
ExpressionAtlasiO18640. differential.
GenevisibleiO18640. DM.

Interactioni

Subunit structurei

Interacts with the 80S ribosome.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi60209. 35 interactions.
DIPiDIP-17169N.
IntActiO18640. 29 interactions.
MINTiMINT-795417.
STRINGi7227.FBpp0303680.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00Ag1-318[»]
ProteinModelPortaliO18640.
SMRiO18640. Positions 2-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati13 – 4432WD 1Add
BLAST
Repeati62 – 9231WD 2Add
BLAST
Repeati104 – 13431WD 3Add
BLAST
Repeati147 – 17933WD 4Add
BLAST
Repeati191 – 22131WD 5Add
BLAST
Repeati232 – 26130WD 6Add
BLAST
Repeati282 – 31231WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0279. Eukaryota.
ENOG410XQGZ. LUCA.
GeneTreeiENSGT00840000129847.
InParanoidiO18640.
KOiK14753.
OMAiATSMENP.
OrthoDBiEOG091G0KZQ.
PhylomeDBiO18640.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETLQLRGT LIGHNGWVTQ IATNPKDPDT IISASRDKTL IVWKLTRDED
60 70 80 90 100
TNYGYPQKRL YGHSHFISDV VLSSDGNYAL SGSWDQTLRL WDLAAGKTTR
110 120 130 140 150
RFEGHTKDVL SVAFSADNRQ IVSGSRDKTI KLWNTLAECK FTIQEDGHTD
160 170 180 190 200
WVSCVRFSPN HSNPIIVSCG WDRTVKVWNL ANCKLKNNHH GHNGYLNTVT
210 220 230 240 250
VSPDGSLCTS GGKDSKALLW DLNDGKNLYT LEHNDIINAL CFSPNRYWLC
260 270 280 290 300
VAYGPSIKIW DLACKKTVEE LRPEVVSPTS KADQPQCLSL AWSTDGQTLF
310
AGYSDNTIRV WQVSVSAH
Length:318
Mass (Da):35,618
Last modified:June 1, 2001 - v2
Checksum:i202930BE51AEE822
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041G → R in AAB72148 (PubMed:9296523).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96491 mRNA. Translation: AAB72148.1.
AE014134 Genomic DNA. Translation: AAF52566.1.
AY071661 mRNA. Translation: AAL49283.1.
RefSeqiNP_001260218.1. NM_001273289.1.
NP_001285723.1. NM_001298794.1.
NP_477269.1. NM_057921.4.
UniGeneiDm.6830.

Genome annotation databases

EnsemblMetazoaiFBtr0079565; FBpp0079187; FBgn0020618.
FBtr0331238; FBpp0303680; FBgn0020618.
FBtr0345448; FBpp0311572; FBgn0020618.
GeneIDi34070.
KEGGidme:Dmel_CG7111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96491 mRNA. Translation: AAB72148.1.
AE014134 Genomic DNA. Translation: AAF52566.1.
AY071661 mRNA. Translation: AAL49283.1.
RefSeqiNP_001260218.1. NM_001273289.1.
NP_001285723.1. NM_001298794.1.
NP_477269.1. NM_057921.4.
UniGeneiDm.6830.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00Ag1-318[»]
ProteinModelPortaliO18640.
SMRiO18640. Positions 2-315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60209. 35 interactions.
DIPiDIP-17169N.
IntActiO18640. 29 interactions.
MINTiMINT-795417.
STRINGi7227.FBpp0303680.

Proteomic databases

PaxDbiO18640.
PRIDEiO18640.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079565; FBpp0079187; FBgn0020618.
FBtr0331238; FBpp0303680; FBgn0020618.
FBtr0345448; FBpp0311572; FBgn0020618.
GeneIDi34070.
KEGGidme:Dmel_CG7111.

Organism-specific databases

CTDi10399.
FlyBaseiFBgn0020618. Rack1.

Phylogenomic databases

eggNOGiKOG0279. Eukaryota.
ENOG410XQGZ. LUCA.
GeneTreeiENSGT00840000129847.
InParanoidiO18640.
KOiK14753.
OMAiATSMENP.
OrthoDBiEOG091G0KZQ.
PhylomeDBiO18640.

Enzyme and pathway databases

SignaLinkiO18640.

Miscellaneous databases

GenomeRNAii34070.
PROiO18640.

Gene expression databases

BgeeiFBgn0020618.
ExpressionAtlasiO18640. differential.
GenevisibleiO18640. DM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBLP_DROME
AccessioniPrimary (citable) accession number: O18640
Secondary accession number(s): Q9VLW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.