O18635 (C12A2_MUSDO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 CYP12A2
EC=1.14.-.-

Alternative name(s):
CYPXIIA2

Gene names

Name:

CYP12A2

Organism

Musca domestica (House fly)

Taxonomic identifier

7370 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Muscoidea › Muscidae › Musca

Protein attributes

Sequence length	537 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor	Heme group By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 537	537	Cytochrome P450 CYP12A2		PRO_0000051923
Sites
	Metal binding	483	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O18635 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 20BFE40CF965A82A	FASTA	537	61,709
	10 20 30 40 50 60 MLKTKQQIIA LNRFRCWTSN LPGLQQQCRN QSTVTAASSE WEQAKPLSEM PTISPFQLLR 70 80 90 100 110 120 HFLPGGKYTN LDTTQLMLAF RRDFGPIVYF KGSLGKPDVV MTNNPHDFEK ALHNQGIWPM 130 140 150 160 170 180 RPGMEYLSYH RQVHRKDIFQ GVEGLLGSQG EAWGSFRSAV NPVLMQPKNV HLYFNKMSEV 190 200 210 220 230 240 NKEFMERIRK IRDPQTLEVP DNFEEEINRW TLESVSVVAL DKQLGLITKN RDDPTPKRLF 250 260 270 280 290 300 KALTDFFEAS GDLEFQPSIW KYIKTPTFKK AIRSLDEITD ITKMYVDEAF ERIEAENKNR 310 320 330 340 350 360 NVEKPENEKS VLEKLVKIDK QIAMVMAMDM LMAGVDTTSS TFTGLLLCLA KNPEKQKKLR 370 380 390 400 410 420 EEIMQLLPQK DSEFNEAVFK NMPYLRACIK ESLRVYPLTV GNARTQANDV VISGYRVPKG 430 440 450 460 470 480 TLISMNSVTL IKDDAHYPRA SEFLPERWLR ASKENEKSAE CPHALKASSP FVYLPFGFGS 490 500 510 520 530 RSCIGRRIAE MELELGIARL IRNFHVEFNY PTDNAFKSLL ISVPNIPLKF KFTDVDN

References

[1]	Guzov V.M., Feyereisen R. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Rutgers.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U94698 mRNA. Translation: AAC98527.1.
3D structure databases
ProteinModelPortal	O18635.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C12A2_MUSDO

Accession

Primary (citable) accession number: O18635

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	June 28, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)