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O18598 (GST1_BLAGE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase

EC=2.5.1.18
Alternative name(s):
GST class-sigma
Major allergen Bla g 5
Allergen=Bla g 5
OrganismBlattella germanica (German cockroach) (Blatta germanica)
Taxonomic identifier6973 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Allergenic properties

Causes an allergic reaction in human. Causes positive immediate skin tests in cockroach-allergic patients using as little as 3 pg of recombinant protein. Associated with asthma.

Sequence similarities

Belongs to the GST superfamily. Sigma family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   DiseaseAllergen
   Molecular functionTransferase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 204203Glutathione S-transferase
PRO_0000185916

Regions

Domain3 – 8078GST N-terminal
Domain82 – 204123GST C-terminal
Region64 – 652Glutathione binding By similarity

Sites

Binding site91Glutathione By similarity
Binding site401Glutathione By similarity
Binding site441Glutathione By similarity

Experimental info

Sequence conflict101C → F AA sequence Ref.1

Sequences

Sequence LengthMass (Da)Tools
O18598 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 4CBE9339C913551C

FASTA20423,334
        10         20         30         40         50         60 
MAPSYKLTYC PVKALGEPIR FLLSYGEKDF EDYRFQEGDW PNLKPSMPFG KTPVLEIDGK 

        70         80         90        100        110        120 
QTHQSVAISR YLGKQFGLSG KDDWENLEID MIVDTISDFR AAIANYHYDA DENSKQKKWD 

       130        140        150        160        170        180 
PLKKETIPYY TKKFDEVVKA NGGYLAAGKL TWADFYFVAI LDYLNHMAKE DLVANQPNLK 

       190        200 
ALREKVLGLP AIKAWVAKRP PTDL 

« Hide

References

[1]"Induction of IgE antibody responses by glutathione S-transferase from the German cockroach (Blattella germanica)."
Arruda L.K., Vailes L.D., Platts-Mills T.A.E., Hayden M.L., Chapman M.D.
J. Biol. Chem. 272:20907-20912(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-204, PROTEIN SEQUENCE OF 2-39.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U92412 mRNA. Translation: AAB72147.1.

3D structure databases

ProteinModelPortalO18598.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome144. Bla g 5.
3142. Bla g 5.0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGST1_BLAGE
AccessionPrimary (citable) accession number: O18598
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries