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Reviewed, UniProtKB/Swiss-Prot O18596 (C4D10_DROMT)

Last modified June 16, 2009. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 4d10
    EC=1.14.-.-
Alternative name(s):
    CYPIVD10
Gene names
Name: Cyp4d10
OrganismDrosophila mettleri (Fruit fly)
Taxonomic identifier7228 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila

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Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May play an important role in the maintenance of specific insect-host plant relationships. May be involved in xenobiotic metabolism.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein Potential. Microsome membrane; Peripheral membrane protein Potential.

Induction

By isoquinoline alkaloids and phenobarbital.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

microsome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionelectron carrier activity

Inferred from electronic annotation. Source: InterPro

heme binding

Inferred from electronic annotation. Source: InterPro

monooxygenase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Cytochrome P450 4d10
PRO_0000051836

Sites

Metal binding4571Iron (heme axial ligand) By similarity
Binding site3171Heme (covalent; via 1 link) By similarity

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Sequences

Sequence LengthMass (Da)Tools
O18596-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 294931CC398B5759

FASTA51358,731
        10         20         30         40         50         60 
MSLSLPPLIA VACLVVALAR ISWLPLRSWL RRRRRTHQLA AQLPGPRNLP LLGNFHMFFG 

        70         80         90        100        110        120 
LEPWQVPHLI NQLAKKYDGT FKLKMGSNFS LMMFQPRDIE VVLGSSQLLD KAVEYSFLRG 

       130        140        150        160        170        180 
WLNDGLLLSG GRKWHRRRKI ITPAFHFRIL ESYDEIFDRQ TRLLIHKWQQ TLGHSFDLGH 

       190        200        210        220        230        240 
DVHLFTLDVI CETAMGVSTN AQTNADSDYV RAVKTISTVL HKRMFNIFYR FDLTYMLTPL 

       250        260        270        280        290        300 
AWAERRALNV LHKFTEKIIV QRREELLRGG VTQTTDGADV GAKSKMVFLD ILLQSNIDDK 

       310        320        330        340        350        360 
PLTNLDIREE VDTFMFEGHD TTSSGITFFF YNIALYPECQ RKCVEEIVSV LGKDTETPVT 

       370        380        390        400        410        420 
YDLLNNLNYM DLCIKETLRM YPSVPLLGRK VLQECEINGK IIPAGTNIGI SPLFLGRSED 

       430        440        450        460        470        480 
ISSEPNTFKP ERFDVVTSAE KLNPHAYIPF SAGPRNCIGQ KFAMLEIKAI AANVLRHYEI 

       490        500        510 
EFVGNAEESP VLIAELILRT KDPLMFKLKK RVI

« Hide

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References

[1]"Induction by alkaloids and phenobarbital of family 4 cytochrome P450s in Drosophila: evidence for involvement in host plant utilization."
Danielson P.B., Foster J.L., McMahill M.M., Smith M.K., Fogleman J.C.
Mol. Gen. Genet. 259:54-59(1998) [PubMed: 9738880] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Tissue: Larva.

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Cross-references

Sequence databases

U91634 mRNA. Translation: AAB68664.1.

3D structure databases

ModBaseSearch...

Organism-specific databases

FlyBaseFBgn0021345. Dmet\Cyp4d10.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR017973. Cyt_P450_C.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameC4D10_DROMT
AccessionPrimary (citable) accession number: O18596
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents