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Protein
Submitted name:

Extracellular Cu/Zn superoxide dismutase

Gene

OvSOD2

Organism
Onchocerca volvulus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Extracellular Cu/Zn superoxide dismutaseImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:OvSOD2Imported
Synonyms:WBGene00248325Imported
OrganismiOnchocerca volvulusImported
Taxonomic identifieri6282 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeOnchocerca
ProteomesiUP000024404 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliO18483.
SMRiO18483. Positions 44-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18483-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINSFIVIFL SFLIFINYAN LVYVEATHVY GRRSHSNGMH GNGARRAVAV
60 70 80 90 100
LRGDAGVSGI IYFQQDSGGS ITTISGSVSG LTPGLHGFHV HQYGDQTNGC
110 120 130 140 150
TSAGGHYNPY GKTHGDPNDR IKHIGDLGNI VAGANGVAEV YINSYHIKLR
160 170 180 190 200
GPLSVIGRSL VVHENPDDLG QGTGNMREES LKTGNAGSRL ACAVIGIAAV

S
Length:201
Mass (Da):21,148
Last modified:January 1, 1998 - v1
Checksum:i9BD9E833C71AEE5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13778 Genomic DNA. No translation available.
AF009621 Genomic DNA. Translation: AAB64227.1.

Genome annotation databases

EnsemblMetazoaiOVOC11516; OVOC11516; WBGene00248325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13778 Genomic DNA. No translation available.
AF009621 Genomic DNA. Translation: AAB64227.1.

3D structure databases

ProteinModelPortaliO18483.
SMRiO18483. Positions 44-198.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiOVOC11516; OVOC11516; WBGene00248325.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Tawe W., Eschbach M.-L., Walter R.D., Henkle-Duehrsen K.J.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Genome sequencing of Onchocerca volvulus."
    Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S., Berriman M.
    Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. EnsemblMetazoa
    Submitted (APR-2014) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiO18483_ONCVO
AccessioniPrimary (citable) accession number: O18483
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: April 1, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.