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Protein

Ecdysone receptor

Gene

EcR

Organism
Heliothis virescens (Tobacco budworm moth)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ecdysone. Binds to ecdysone response elements (ECRES) (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi163 – 23573Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri163 – 18321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22325NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ecdysone receptor
Alternative name(s):
20-hydroxy-ecdysone receptor
Short name:
20E receptor
EcRH
Ecdysteroid receptor
HvEcR
Nuclear receptor subfamily 1 group H member 1
Gene namesi
Name:EcR
Synonyms:NR1H1
OrganismiHeliothis virescens (Tobacco budworm moth)
Taxonomic identifieri7102 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHeliothis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2366582.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Ecdysone receptorPRO_0000053528Add
BLAST

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q7SIF62EBI-1037411,EBI-1037399

Protein-protein interaction databases

IntActiO18473. 1 interaction.

Structurei

Secondary structure

1
576
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi313 – 32816Combined sources
Helixi334 – 3418Combined sources
Helixi352 – 37423Combined sources
Helixi378 – 3803Combined sources
Helixi383 – 40321Combined sources
Turni408 – 4114Combined sources
Beta strandi412 – 4143Combined sources
Turni416 – 4183Combined sources
Beta strandi419 – 4213Combined sources
Helixi423 – 4286Combined sources
Turni429 – 4313Combined sources
Helixi432 – 44615Combined sources
Turni447 – 4493Combined sources
Helixi452 – 46312Combined sources
Helixi473 – 49422Combined sources
Turni495 – 4973Combined sources
Helixi501 – 53131Combined sources
Helixi538 – 5436Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R1KX-ray2.90D305-550[»]
1R20X-ray3.00D306-550[»]
2R40X-ray2.40D305-550[»]
4UMMelectron microscopy11.60E157-243[»]
G305-550[»]
ProteinModelPortaliO18473.
SMRiO18473. Positions 157-243, 308-547.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO18473.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 162162ModulatingSequence analysisAdd
BLAST
Regioni326 – 545220Hormone-bindingSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri163 – 18321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22325NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003069. Ecdystd_rcpt.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01283. ECDYSTEROIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGARGYRR CDTLADMRRR WYNNGPFQTL RMLEESSSEV TSSSALGLPP
60 70 80 90 100
AMVMSPESLA SPEIGGLELW GYDDGITYSM AQSLGTCTME QQQPQPQQQP
110 120 130 140 150
QQTQPLPSMP LPMPPTTPKS ENESMSSGRE ELSPASSVNG CSTDGEARRQ
160 170 180 190 200
KKGPAPRQQE ELCLVCGDRA SGYHYNALTC EGCKGFFRRS VTKNAVYICK
210 220 230 240 250
FGHACEMDIY MRRKCQECRL KKCLAVGMRP ECVVPENQCA MKRKEKKAQR
260 270 280 290 300
EKDKLPVSTT TVDDHMPPIM QCDPPPPEAA RILECVQHEV VPRFLNEKLM
310 320 330 340 350
EQNRLKNVPP LTANQKSLIA RLVWYQEGYE QPSEEDLKRV TQSDEDDEDS
360 370 380 390 400
DMPFRQITEM TILTVQLIVE FAKGLPGFAK ISQSDQITLL KACSSEVMML
410 420 430 440 450
RVARRYDAAT DSVLFANNQA YTRDNYRKAG MAYVIEDLLH FCRCMYSMMM
460 470 480 490 500
DNVHYALLTA IVIFSDRPGL EQPLLVEEIQ RYYLNTLRVY ILNQNSASPR
510 520 530 540 550
GAVIFGEILG ILTEIRTLGM QNSNMCISLK LKNRKLPPFL EEIWDVADVA
560 570
TTATPVAAEA PAPLAPAPPA RPPATV
Length:576
Mass (Da):64,638
Last modified:January 1, 1998 - v1
Checksum:iD13EF7877BF263A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09009 mRNA. Translation: CAA70212.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09009 mRNA. Translation: CAA70212.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R1KX-ray2.90D305-550[»]
1R20X-ray3.00D306-550[»]
2R40X-ray2.40D305-550[»]
4UMMelectron microscopy11.60E157-243[»]
G305-550[»]
ProteinModelPortaliO18473.
SMRiO18473. Positions 157-243, 308-547.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO18473. 1 interaction.

Chemistry

ChEMBLiCHEMBL2366582.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO18473.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003069. Ecdystd_rcpt.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01283. ECDYSTEROIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECR_HELVI
AccessioniPrimary (citable) accession number: O18473
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: October 14, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.