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O18416 (TPM_DERPT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tropomyosin
Alternative name(s):
Allergen=Der p 10
OrganismDermatophagoides pteronyssinus (European house dust mite)
Taxonomic identifier6956 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Subunit structure

Homodimer By similarity.

Domain

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Allergenic properties

Causes an allergic reaction in human. Binds to IgE.

Sequence similarities

Belongs to the tropomyosin family.

Ontologies

Keywords
   DiseaseAllergen
   DomainCoiled coil
Repeat
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Tropomyosin
PRO_0000205679

Regions

Coiled coil1 – 284284 By similarity

Experimental info

Sequence conflict61N → K in AAB69424. Ref.2
Sequence conflict2541G → D in AAB69424. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O18416 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 278AAF663E585DB9

FASTA28432,901
        10         20         30         40         50         60 
MEAIKNKMQA MKLEKDNAID RAEIAEQKAR DANLRAEKSE EEVRALQKKI QQIENELDQV 

        70         80         90        100        110        120 
QEQLSAANTK LEEKEKALQT AEGDVAALNR RIQLIEEDLE RSEERLKIAT AKLEEASQSA 

       130        140        150        160        170        180 
DESERMRKML EHRSITDEER MEGLENQLKE ARMMAEDADR KYDEVARKLA MVEADLERAE 

       190        200        210        220        230        240 
ERAETGESKI VELEEELRVV GNNLKSLEVS EEKAQQREEA HEQQIRIMTT KLKEAEARAE 

       250        260        270        280 
FAERSVQKLQ KEVGRLEDEL VHEKEKYKSI SDELDQTFAE LTGY 

« Hide

References

[1]"Sequencing and high level expression in Escherichia coli of the tropomyosin allergen (Der p 10) from Dermatophagoides pteronyssinus."
Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez J., Martinez A., Palacios R.
Biochim. Biophys. Acta 1397:27-30(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Smith W., Mills K.L., Thomas W.R.
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y14906 mRNA. Translation: CAA75141.1.
AF016278 mRNA. Translation: AAB69424.1.

3D structure databases

ProteinModelPortalO18416.
SMRO18416. Positions 1-283.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome311. Der p 10.
3258. Der p 10.0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000533. Tropomyosin.
[Graphical view]
PfamPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSPR00194. TROPOMYOSIN.
PROSITEPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPM_DERPT
AccessionPrimary (citable) accession number: O18416
Secondary accession number(s): O16188
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries