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O18416

- TPM_DERPT

UniProt

O18416 - TPM_DERPT

Protein

Tropomyosin

Gene
N/A
Organism
Dermatophagoides pteronyssinus (European house dust mite)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tropomyosin
    Alternative name(s):
    Allergen: Der p 10
    OrganismiDermatophagoides pteronyssinus (European house dust mite)
    Taxonomic identifieri6956 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Binds to IgE.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei311. Der p 10.
    3258. Der p 10.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284TropomyosinPRO_0000205679Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO18416.
    SMRiO18416. Positions 1-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1 – 284284By similarityAdd
    BLAST

    Domaini

    The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

    Sequence similaritiesi

    Belongs to the tropomyosin family.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Family and domain databases

    InterProiIPR000533. Tropomyosin.
    [Graphical view]
    PfamiPF00261. Tropomyosin. 1 hit.
    [Graphical view]
    PRINTSiPR00194. TROPOMYOSIN.
    PROSITEiPS00326. TROPOMYOSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O18416-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAIKNKMQA MKLEKDNAID RAEIAEQKAR DANLRAEKSE EEVRALQKKI    50
    QQIENELDQV QEQLSAANTK LEEKEKALQT AEGDVAALNR RIQLIEEDLE 100
    RSEERLKIAT AKLEEASQSA DESERMRKML EHRSITDEER MEGLENQLKE 150
    ARMMAEDADR KYDEVARKLA MVEADLERAE ERAETGESKI VELEEELRVV 200
    GNNLKSLEVS EEKAQQREEA HEQQIRIMTT KLKEAEARAE FAERSVQKLQ 250
    KEVGRLEDEL VHEKEKYKSI SDELDQTFAE LTGY 284
    Length:284
    Mass (Da):32,901
    Last modified:January 1, 1998 - v1
    Checksum:i278AAF663E585DB9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61N → K in AAB69424. 1 PublicationCurated
    Sequence conflicti254 – 2541G → D in AAB69424. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14906 mRNA. Translation: CAA75141.1.
    AF016278 mRNA. Translation: AAB69424.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14906 mRNA. Translation: CAA75141.1 .
    AF016278 mRNA. Translation: AAB69424.1 .

    3D structure databases

    ProteinModelPortali O18416.
    SMRi O18416. Positions 1-283.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 311. Der p 10.
    3258. Der p 10.0101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000533. Tropomyosin.
    [Graphical view ]
    Pfami PF00261. Tropomyosin. 1 hit.
    [Graphical view ]
    PRINTSi PR00194. TROPOMYOSIN.
    PROSITEi PS00326. TROPOMYOSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing and high level expression in Escherichia coli of the tropomyosin allergen (Der p 10) from Dermatophagoides pteronyssinus."
      Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez J., Martinez A., Palacios R.
      Biochim. Biophys. Acta 1397:27-30(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Smith W., Mills K.L., Thomas W.R.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTPM_DERPT
    AccessioniPrimary (citable) accession number: O18416
    Secondary accession number(s): O16188
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3