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O18416

- TPM_DERPT

UniProt

O18416 - TPM_DERPT

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Protein
Tropomyosin
Gene
N/A
Organism
Dermatophagoides pteronyssinus (European house dust mite)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin
Alternative name(s):
Allergen: Der p 10
OrganismiDermatophagoides pteronyssinus (European house dust mite)
Taxonomic identifieri6956 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei311. Der p 10.
3258. Der p 10.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Tropomyosin
PRO_0000205679Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliO18416.
SMRiO18416. Positions 1-283.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 284284 By similarity
Add
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18416-1 [UniParc]FASTAAdd to Basket

« Hide

MEAIKNKMQA MKLEKDNAID RAEIAEQKAR DANLRAEKSE EEVRALQKKI    50
QQIENELDQV QEQLSAANTK LEEKEKALQT AEGDVAALNR RIQLIEEDLE 100
RSEERLKIAT AKLEEASQSA DESERMRKML EHRSITDEER MEGLENQLKE 150
ARMMAEDADR KYDEVARKLA MVEADLERAE ERAETGESKI VELEEELRVV 200
GNNLKSLEVS EEKAQQREEA HEQQIRIMTT KLKEAEARAE FAERSVQKLQ 250
KEVGRLEDEL VHEKEKYKSI SDELDQTFAE LTGY 284
Length:284
Mass (Da):32,901
Last modified:January 1, 1998 - v1
Checksum:i278AAF663E585DB9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61N → K in AAB69424. 1 Publication
Sequence conflicti254 – 2541G → D in AAB69424. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14906 mRNA. Translation: CAA75141.1.
AF016278 mRNA. Translation: AAB69424.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14906 mRNA. Translation: CAA75141.1 .
AF016278 mRNA. Translation: AAB69424.1 .

3D structure databases

ProteinModelPortali O18416.
SMRi O18416. Positions 1-283.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 311. Der p 10.
3258. Der p 10.0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR000533. Tropomyosin.
[Graphical view ]
Pfami PF00261. Tropomyosin. 1 hit.
[Graphical view ]
PRINTSi PR00194. TROPOMYOSIN.
PROSITEi PS00326. TROPOMYOSIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing and high level expression in Escherichia coli of the tropomyosin allergen (Der p 10) from Dermatophagoides pteronyssinus."
    Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez J., Martinez A., Palacios R.
    Biochim. Biophys. Acta 1397:27-30(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Smith W., Mills K.L., Thomas W.R.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTPM_DERPT
AccessioniPrimary (citable) accession number: O18416
Secondary accession number(s): O16188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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