O18416 (TPM_DERPT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Tropomyosin Alternative name(s): Allergen=Der p 10
Organism	Dermatophagoides pteronyssinus (European house dust mite)
Taxonomic identifier	6956 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Acari › Acariformes › Sarcoptiformes › Astigmata › Psoroptidia › Analgoidea › Pyroglyphidae › Dermatophagoidinae › Dermatophagoides

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Subunit structure	Homodimer By similarity.
Domain	The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Allergenic properties	Causes an allergic reaction in human. Binds to IgE.
Sequence similarities	Belongs to the tropomyosin family.

Ontologies

Keywords
Disease	Allergen
Domain	Coiled coil Repeat
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Tropomyosin		PRO_0000205679
Regions
	Coiled coil	1 – 284	284	By similarity
Experimental info
	Sequence conflict	6	1	N → K in AAB69424. Ref.2
	Sequence conflict	254	1	G → D in AAB69424. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O18416 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 278AAF663E585DB9	FASTA	284	32,901
	10 20 30 40 50 60 MEAIKNKMQA MKLEKDNAID RAEIAEQKAR DANLRAEKSE EEVRALQKKI QQIENELDQV 70 80 90 100 110 120 QEQLSAANTK LEEKEKALQT AEGDVAALNR RIQLIEEDLE RSEERLKIAT AKLEEASQSA 130 140 150 160 170 180 DESERMRKML EHRSITDEER MEGLENQLKE ARMMAEDADR KYDEVARKLA MVEADLERAE 190 200 210 220 230 240 ERAETGESKI VELEEELRVV GNNLKSLEVS EEKAQQREEA HEQQIRIMTT KLKEAEARAE 250 260 270 280 FAERSVQKLQ KEVGRLEDEL VHEKEKYKSI SDELDQTFAE LTGY

References

[1]	"Sequencing and high level expression in Escherichia coli of the tropomyosin allergen (Der p 10) from Dermatophagoides pteronyssinus." Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez J., Martinez A., Palacios R. Biochim. Biophys. Acta 1397:27-30(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Smith W., Mills K.L., Thomas W.R. Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y14906 mRNA. Translation: CAA75141.1. AF016278 mRNA. Translation: AAB69424.1.
3D structure databases
ProteinModelPortal	O18416.
SMR	O18416. Positions 1-283.
ModBase	Search...
Protein family/group databases
Allergome	311. Der p 10. 3258. Der p 10.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000533. Tropomyosin. [Graphical view]
Pfam	PF00261. Tropomyosin. 1 hit. [Graphical view]
PRINTS	PR00194. TROPOMYOSIN.
PROSITE	PS00326. TROPOMYOSIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPM_DERPT

Accession

Primary (citable) accession number: O18416
Secondary accession number(s): O16188

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)