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Protein
Submitted name:

Testis-specific RNP-type RNA binding protein

Gene

aret

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: FlyBase
  • mRNA binding Source: FlyBase
  • nucleotide binding Source: InterPro
  • RNA binding Source: FlyBase

GO - Biological processi

  • female germ-line stem cell population maintenance Source: FlyBase
  • germarium-derived female germ-line cyst formation Source: FlyBase
  • germ cell development Source: FlyBase
  • germ-line stem cell division Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • inter-male aggressive behavior Source: FlyBase
  • mRNA polyadenylation Source: FlyBase
  • negative regulation of oskar mRNA translation Source: FlyBase
  • negative regulation of translation Source: FlyBase
  • oogenesis Source: FlyBase
  • positive regulation of exit from mitosis Source: FlyBase
  • positive regulation of stem cell differentiation Source: FlyBase
  • regulation of alternative mRNA splicing, via spliceosome Source: FlyBase
  • regulation of myofibril size Source: FlyBase
  • regulation of oskar mRNA translation Source: FlyBase
  • sarcomere organization Source: FlyBase
  • spermatid development Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Testis-specific RNP-type RNA binding proteinImported
Gene namesi
Name:aretImported
Synonyms:brunoImported
ORF Names:CG31762Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0000114. aret.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • nuclear body Source: FlyBase
  • nuclear membrane Source: FlyBase
  • nucleus Source: FlyBase
  • P granule Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO18409.
PRIDEiO18409.

Expressioni

Gene expression databases

BgeeiO18409.
ExpressionAtlasiO18409. differential.

Interactioni

Protein-protein interaction databases

IntActiO18409. 4 interactions.
STRINGi7227.FBpp0079926.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KHCNMR-A684-801[»]
ProteinModelPortaliO18409.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO18409.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini355 – 43682RRM (RNA recognition motif)InterPro annotationAdd
BLAST
Domaini442 – 52382RRM (RNA recognition motif)InterPro annotationAdd
BLAST
Domaini724 – 80279RRM (RNA recognition motif)InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili178 – 21033Sequence analysisAdd
BLAST
Coiled coili518 – 54528Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0144. Eukaryota.
ENOG410XNTW. LUCA.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSLDALAG KIATATPGTG AVTADSKNTQ SLHHHHRLDY DYSAVEIEPP
60 70 80 90 100
AEQLANSPRS ERERLQQAQQ AYEQQAQAEL EFGLAEVDAK LTQLKSSHSL
110 120 130 140 150
QHHHSHHHQL QRHTALHQQQ QQLHHHQPHH NHHHHHPYQR PRPTSPPQQQ
160 170 180 190 200
TSTYQQQLSQ LAALQDHHDL LQTQQELFHK QLATMQEYQR ERERERERER
210 220 230 240 250
ERERERERDR SSFIDNSDYD SQTEFKICLR DSAFGMSDKS SSATNSLPNS
260 270 280 290 300
PIHSNNNNPS LLNNNNNNSN GTSSNNSLNV GNNSSNPSLG GTNSNALVSV
310 320 330 340 350
GSNGIMSAAG LVNNNNNPCS ANRNVVAMVD DDACFRLDTD ATVTYGEKEP
360 370 380 390 400
DPDNIKMFVG QVPKSMDESQ LREMFEEYGA VHSINVLRDK ATGISKGCCF
410 420 430 440 450
VTFYTRRAAL KAQDALHNVK TLNGMYHPIQ MKPADSENRN ERKLFVGMLN
460 470 480 490 500
KKLNENDVRK LFEVHGAIEE CTVLRDQNGQ SKGCAFVTFA TKHAAISAIK
510 520 530 540 550
VTLSQNKIME GCTSPLVVKF ADTQKEKEQK KIQQIQANLW NLASNINIPL
560 570 580 590 600
GQTATSVTTP ILPNPAQQPS PVLGADAITP ASIQLLQQLQ AVGLQHQLLQ
610 620 630 640 650
ALTGLGAQQS SSATDTSAVA AAGLLTPMTV QNLAAIAAMT QPSLSNAAAA
660 670 680 690 700
AARATSPGSA QLTNTAALLW SDPNPMASAY MSTAAGLPQF GSASALSTSP
710 720 730 740 750
LASVALSAAA AAAAGKQIEG PEGCNLFIYH LPQEFTDTDL ASTFLPFGNV
760 770 780 790 800
ISAKVFIDKQ TSLSKCFGFV SFDNPDSAQV AIKAMNGFQV GTKRLKVQLK

KPKDSKPY
Length:808
Mass (Da):88,088
Last modified:January 1, 1998 - v1
Checksum:i55DAD7C50F9BADC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73846 mRNA. Translation: AAB61993.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73846 mRNA. Translation: AAB61993.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KHCNMR-A684-801[»]
ProteinModelPortaliO18409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO18409. 4 interactions.
STRINGi7227.FBpp0079926.

Proteomic databases

PaxDbiO18409.
PRIDEiO18409.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0000114. aret.

Phylogenomic databases

eggNOGiKOG0144. Eukaryota.
ENOG410XNTW. LUCA.

Miscellaneous databases

EvolutionaryTraceiO18409.

Gene expression databases

BgeeiO18409.
ExpressionAtlasiO18409. differential.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and mutant analysis of bruno, a Drosophila translational repressor, reveals multiple roles in development and extensive evolutionary conservation."
    Webster P.J., Liang L., Lasko P., Macdonald P.M.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Bruno protein contains an expanded RNA recognition motif."
    Lyon A.M., Reveal B.S., Macdonald P.M., Hoffman D.W.
    Biochemistry 48:12202-12212(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 684-801.

Entry informationi

Entry nameiO18409_DROME
AccessioniPrimary (citable) accession number: O18409
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: March 16, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.