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Protein

Surfeit locus protein 4 homolog

Gene

Surf4

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • lateral inhibition Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 4 homolog
Gene namesi
Name:Surf4
Synonyms:Surf-4
ORF Names:CG6202
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0019925. Surf4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence analysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endomembrane system Source: FlyBase
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • fusome Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Surfeit locus protein 4 homologPRO_0000127667Add
BLAST

Proteomic databases

PaxDbiO18405.
PRIDEiO18405.

Expressioni

Gene expression databases

BgeeiO18405.
GenevisibleiO18405. DM.

Interactioni

Protein-protein interaction databases

BioGridi66927. 38 interactions.
DIPiDIP-19105N.
MINTiMINT-831374.
STRINGi7227.FBpp0082571.

Structurei

3D structure databases

ProteinModelPortaliO18405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi267 – 2704Di-lysine motifSequence analysis

Domaini

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Sequence similaritiesi

Belongs to the SURF4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3998. Eukaryota.
COG2259. LUCA.
GeneTreeiENSGT00530000064123.
InParanoidiO18405.
OMAiDQLWYLQ.
OrthoDBiEOG7GTT4K.
PhylomeDBiO18405.

Family and domain databases

InterProiIPR002995. Surf4.
[Graphical view]
PfamiPF02077. SURF4. 1 hit.
[Graphical view]
PROSITEiPS01339. SURF4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPNEYIAK TEDVAEQVIK RGKNVLPTVA RLCLIATFFE DGLRMYIQWN
60 70 80 90 100
EQREYMDMSW GCGKFLATVF VLVNLLGQLG GCGMVMARFK VDIAVGLLFF
110 120 130 140 150
IVVLQTVAYS ILWDFQFLLR NFALIGALLL VLAEARIEGR SLFAGVPSMG
160 170 180 190 200
ENKPKNFMQL AGRILLAFMF ITLIRFELSV WQVIQDIIGS ILMVLVVLGY
210 220 230 240 250
KTKLSALILV ALLTILNLYH NAWWTIPSYK PLRDFLKYDF FQTLSVIGGL
260 270
LMIVSLGPGG VSMDEHKKKW
Length:270
Mass (Da):30,546
Last modified:January 1, 1998 - v1
Checksum:iFEFA7D525A83C890
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14823 Genomic DNA. Translation: CAA75100.1.
AE014297 Genomic DNA. Translation: AAF55176.1.
AY118406 mRNA. Translation: AAM48435.1.
RefSeqiNP_477222.1. NM_057874.5.
UniGeneiDm.4798.

Genome annotation databases

EnsemblMetazoaiFBtr0083117; FBpp0082571; FBgn0019925.
GeneIDi41864.
KEGGidme:Dmel_CG6202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14823 Genomic DNA. Translation: CAA75100.1.
AE014297 Genomic DNA. Translation: AAF55176.1.
AY118406 mRNA. Translation: AAM48435.1.
RefSeqiNP_477222.1. NM_057874.5.
UniGeneiDm.4798.

3D structure databases

ProteinModelPortaliO18405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66927. 38 interactions.
DIPiDIP-19105N.
MINTiMINT-831374.
STRINGi7227.FBpp0082571.

Proteomic databases

PaxDbiO18405.
PRIDEiO18405.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083117; FBpp0082571; FBgn0019925.
GeneIDi41864.
KEGGidme:Dmel_CG6202.

Organism-specific databases

CTDi6836.
FlyBaseiFBgn0019925. Surf4.

Phylogenomic databases

eggNOGiKOG3998. Eukaryota.
COG2259. LUCA.
GeneTreeiENSGT00530000064123.
InParanoidiO18405.
OMAiDQLWYLQ.
OrthoDBiEOG7GTT4K.
PhylomeDBiO18405.

Enzyme and pathway databases

ReactomeiR-DME-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

ChiTaRSiSurf4. fly.
GenomeRNAii41864.
PROiO18405.

Gene expression databases

BgeeiO18405.
GenevisibleiO18405. DM.

Family and domain databases

InterProiIPR002995. Surf4.
[Graphical view]
PfamiPF02077. SURF4. 1 hit.
[Graphical view]
PROSITEiPS01339. SURF4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Surfeit locus gene homologs are widely distributed in invertebrate genomes."
    Armes N., Fried M.
    Mol. Cell. Biol. 16:5591-5596(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "A Drosophila full-length cDNA resource."
    Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
    Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiSURF4_DROME
AccessioniPrimary (citable) accession number: O18405
Secondary accession number(s): A4V2Y8, Q9VF84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.