Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Surfeit locus protein 4 homolog

Gene

Surf4

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • lateral inhibition Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.
R-DME-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 4 homolog
Gene namesi
Name:Surf4
Synonyms:Surf-4
ORF Names:CG6202
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0019925. Surf4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001276671 – 270Surfeit locus protein 4 homologAdd BLAST270

Proteomic databases

PaxDbiO18405.
PRIDEiO18405.

Expressioni

Gene expression databases

BgeeiFBgn0019925.
GenevisibleiO18405. DM.

Interactioni

Protein-protein interaction databases

BioGridi66927. 39 interactors.
DIPiDIP-19105N.
MINTiMINT-831374.
STRINGi7227.FBpp0082571.

Structurei

3D structure databases

ProteinModelPortaliO18405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi267 – 270Di-lysine motifSequence analysis4

Domaini

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Sequence similaritiesi

Belongs to the SURF4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3998. Eukaryota.
COG2259. LUCA.
GeneTreeiENSGT00530000064123.
InParanoidiO18405.
KOiK20369.
OMAiDRKMYFQ.
OrthoDBiEOG091G0H3P.
PhylomeDBiO18405.

Family and domain databases

InterProiView protein in InterPro
IPR002995. Surf4.
PfamiView protein in Pfam
PF02077. SURF4. 1 hit.
PROSITEiView protein in PROSITE
PS01339. SURF4. 1 hit.

Sequencei

Sequence statusi: Complete.

O18405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPNEYIAK TEDVAEQVIK RGKNVLPTVA RLCLIATFFE DGLRMYIQWN
60 70 80 90 100
EQREYMDMSW GCGKFLATVF VLVNLLGQLG GCGMVMARFK VDIAVGLLFF
110 120 130 140 150
IVVLQTVAYS ILWDFQFLLR NFALIGALLL VLAEARIEGR SLFAGVPSMG
160 170 180 190 200
ENKPKNFMQL AGRILLAFMF ITLIRFELSV WQVIQDIIGS ILMVLVVLGY
210 220 230 240 250
KTKLSALILV ALLTILNLYH NAWWTIPSYK PLRDFLKYDF FQTLSVIGGL
260 270
LMIVSLGPGG VSMDEHKKKW
Length:270
Mass (Da):30,546
Last modified:January 1, 1998 - v1
Checksum:iFEFA7D525A83C890
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14823 Genomic DNA. Translation: CAA75100.1.
AE014297 Genomic DNA. Translation: AAF55176.1.
AY118406 mRNA. Translation: AAM48435.1.
RefSeqiNP_477222.1. NM_057874.5.
UniGeneiDm.4798.

Genome annotation databases

EnsemblMetazoaiFBtr0083117; FBpp0082571; FBgn0019925.
GeneIDi41864.
KEGGidme:Dmel_CG6202.

Similar proteinsi

Entry informationi

Entry nameiSURF4_DROME
AccessioniPrimary (citable) accession number: O18405
Secondary accession number(s): A4V2Y8, Q9VF84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families