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Protein
Submitted name:

Fizzy-related protein

Gene

rap

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of anaphase-promoting complex activity Source: InterPro
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
  • compound eye morphogenesis Source: FlyBase
  • eye-antennal disc morphogenesis Source: FlyBase
  • glial cell differentiation Source: FlyBase
  • glial cell migration Source: FlyBase
  • negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation Source: FlyBase
  • positive regulation of exit from mitosis Source: FlyBase
  • positive regulation of mitotic metaphase/anaphase transition Source: GOC
  • protein catabolic process Source: FlyBase
  • regulation of mitotic nuclear division Source: FlyBase
  • sensory perception of pain Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-DME-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-DME-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-DME-68949. Orc1 removal from chromatin.
R-DME-69656. Cyclin A:Cdk2-associated events at S phase entry.
SignaLinkiO18402.

Names & Taxonomyi

Protein namesi
Submitted name:
Fizzy-related proteinImported
Gene namesi
Name:rapImported
Synonyms:fzrImported
ORF Names:CG3000Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0262699. rap.

Subcellular locationi

GO - Cellular componenti

  • anaphase-promoting complex Source: FlyBase
  • axon Source: FlyBase
  • centriole Source: FlyBase
  • centrosome Source: FlyBase
  • cytoplasm Source: FlyBase
  • spindle Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO18402.
PRIDEiO18402.

Expressioni

Gene expression databases

BgeeiO18402.
ExpressionAtlasiO18402. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0070654.

Structurei

3D structure databases

ProteinModelPortaliO18402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini210 – 465256WD_REPEATS_REGIONInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatUniRule annotationSAAS annotation, WD repeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0305. Eukaryota.
ENOG410XQ8I. LUCA.
HOGENOMiHOG000247776.
OrthoDBiEOG76X602.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR033010. Cdc20/Fizzy.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19918. PTHR19918. 1 hit.
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18402-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSPEYQKRI LKHYSPVARN LFNNFESSTT PTSLDRFIPC RAYNNWQTNF
60 70 80 90 100
ASINKSNDNS PQTSKKQRDC GETARDSLAY SCLLKNELLG SAIDDVKTAG
110 120 130 140 150
EERNENAYTP AAKRSLFKYQ SPTKQDYNGE CPYSLSPVSA KSQKLLRSPR
160 170 180 190 200
KATRKISRIP FKVLDAPELQ DDFYLNLVDW SSQNVLAVGL GSCVYLWSAC
210 220 230 240 250
TSQVTRLCDL SPDANTVTSV SWNERGNTVA VGTHHGYVTV WDVAANKQIN
260 270 280 290 300
KLNGHSARVG ALAWNSDILS SGSRDRWIIQ RDTRTPQLQS ERRLAGHRQE
310 320 330 340 350
VCGLKWSPDN QYLASGGNDN RLYVWNQHSV NPVQSYTEHM AAVKAIAWSP
360 370 380 390 400
HHHGLLASGG GTADRCIRFW NTLTGQPMQC VDTGSQVCNL AWSKHSSELV
410 420 430 440 450
STHGYSQNQI LVWKYPSLTQ VAKLTGHSYR VLYLALSPDG EAIVTGAGDE
460 470
TLRFWNVFSK ARSQKENKSV LNLFANIR
Length:478
Mass (Da):53,507
Last modified:January 1, 1998 - v1
Checksum:i752B799F43762439
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14162 mRNA. Translation: CAA74575.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14162 mRNA. Translation: CAA74575.1.

3D structure databases

ProteinModelPortaliO18402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0070654.

Proteomic databases

PaxDbiO18402.
PRIDEiO18402.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0262699. rap.

Phylogenomic databases

eggNOGiKOG0305. Eukaryota.
ENOG410XQ8I. LUCA.
HOGENOMiHOG000247776.
OrthoDBiEOG76X602.

Enzyme and pathway databases

ReactomeiR-DME-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-DME-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-DME-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-DME-68949. Orc1 removal from chromatin.
R-DME-69656. Cyclin A:Cdk2-associated events at S phase entry.
SignaLinkiO18402.

Miscellaneous databases

ChiTaRSiR. fly.
r. fly.

Gene expression databases

BgeeiO18402.
ExpressionAtlasiO18402. differential.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR033010. Cdc20/Fizzy.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19918. PTHR19918. 1 hit.
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles."
    Sigrist S.J., Lehner C.F.
    Cell 90:671-681(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO18402_DROME
AccessioniPrimary (citable) accession number: O18402
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.