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Protein

Pituitary homeobox homolog Ptx1

Gene

Ptx1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Appears to control physiological cell functions rather than pattern formation during embryogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi262 – 322HomeoboxPROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

  • dendrite morphogenesis Source: FlyBase
  • regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary homeobox homolog Ptx1
Short name:
D-PTX1
Gene namesi
Name:Ptx1
ORF Names:CG1447
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0020912. Ptx1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
  • transcription factor complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492331 – 509Pituitary homeobox homolog Ptx1Add BLAST509

Proteomic databases

PaxDbiO18400.
PRIDEiO18400.

Expressioni

Developmental stagei

First detected in the posterior region of the blastoderm embryo. In later stages of embryonic development, detected in the posterior portion of the midgut, in the developing malpighian tubules, in a subset of ventral somatic muscles, in the developing CNS and in Bolwig's organ.1 Publication

Gene expression databases

BgeeiFBgn0020912.
ExpressionAtlasiO18400. baseline.
GenevisibleiO18400. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0271894.

Structurei

3D structure databases

ProteinModelPortaliO18400.
SMRiO18400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi460 – 473OARPROSITE-ProRule annotationAdd BLAST14
Motifi464 – 470Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 140Ser-richAdd BLAST67

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0486. Eukaryota.
ENOG410ZZ6J. LUCA.
GeneTreeiENSGT00820000126963.
HOGENOMiHOG000079021.
InParanoidiO18400.
OrthoDBiEOG091G0H7U.
PhylomeDBiO18400.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18400-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSSAVGGC GGGGGLGVGV VTSSATALGP GGLTNGGGGV VSGALNGLEA
60 70 80 90 100
MSAESTGLCL QDLVSAGTAN GAGSAGSAES ATTTSTALSS GSTGSSTVNG
110 120 130 140 150
GGSSTSGTEH LHSHHSLHDS SSSVSISPAI SSLMPISSLS HLHHSAGQDL
160 170 180 190 200
VGGYSQHPHH TVVPPHTPKH EPLEKLRIWA ETGDFRDSHS SMTAVANSLD
210 220 230 240 250
STHLNNFQTS STSSISNRSR DRKDGNRSVN ETTIKTENIS SSGHDEPMTT
260 270 280 290 300
SGEEPKNDKK NKRQRRQRTH FTSQQLQELE HTFSRNRYPD MSTREEIAMW
310 320 330 340 350
TNLTEARVRV WFKNRRAKWR KRERNAMNAA VAAADFKSGF GTQFMQPFAD
360 370 380 390 400
DSLYSSYPYN NWTKVPSPLG TKPFPWPVNP LGSMVAGNHH QNSVNCFNTG
410 420 430 440 450
ASGVAVSMNN ASMLPGSMGS SLSNTSNVGA VGAPCPYTTP ANPYMYRSAA
460 470 480 490 500
EPCMSSSMSS SIATLRLKAK QHASAGFGSP YSAPSPVSRS NSAGLSACQY

TGVGVTDVV
Length:509
Mass (Da):53,217
Last modified:October 10, 2003 - v2
Checksum:i6C01616DB9D79C88
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9 – 49GCGGG…LNGLE → LRRGRRSGSGRGHQLGHGLG TGWPDQRGRRSGQWRTQRIG in CAA04801 (PubMed:9431811).CuratedAdd BLAST41
Sequence conflicti108T → A in CAA04801 (PubMed:9431811).Curated1
Sequence conflicti178I → SLFFSV in CAA04801 (PubMed:9431811).Curated1
Sequence conflicti283F → S in CAA04801 (PubMed:9431811).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001519 mRNA. Translation: CAA04801.1.
AE014297 Genomic DNA. Translation: AAF57099.3.
BT009990 mRNA. Translation: AAQ22459.1.
RefSeqiNP_733410.2. NM_170531.4.
UniGeneiDm.7573.

Genome annotation databases

EnsemblMetazoaiFBtr0089389; FBpp0088412; FBgn0020912.
GeneIDi43664.
KEGGidme:Dmel_CG1447.
UCSCiCG1447-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001519 mRNA. Translation: CAA04801.1.
AE014297 Genomic DNA. Translation: AAF57099.3.
BT009990 mRNA. Translation: AAQ22459.1.
RefSeqiNP_733410.2. NM_170531.4.
UniGeneiDm.7573.

3D structure databases

ProteinModelPortaliO18400.
SMRiO18400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0271894.

Proteomic databases

PaxDbiO18400.
PRIDEiO18400.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089389; FBpp0088412; FBgn0020912.
GeneIDi43664.
KEGGidme:Dmel_CG1447.
UCSCiCG1447-RA. d. melanogaster.

Organism-specific databases

CTDi43664.
FlyBaseiFBgn0020912. Ptx1.

Phylogenomic databases

eggNOGiKOG0486. Eukaryota.
ENOG410ZZ6J. LUCA.
GeneTreeiENSGT00820000126963.
HOGENOMiHOG000079021.
InParanoidiO18400.
OrthoDBiEOG091G0H7U.
PhylomeDBiO18400.

Miscellaneous databases

ChiTaRSicrp. fly.
GenomeRNAii43664.
PROiO18400.

Gene expression databases

BgeeiFBgn0020912.
ExpressionAtlasiO18400. baseline.
GenevisibleiO18400. DM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPITX_DROME
AccessioniPrimary (citable) accession number: O18400
Secondary accession number(s): Q9VA26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 10, 2003
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.