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Protein

Importin subunit beta

Gene

Fs(2)Ket

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins (PubMed:11102382). In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup (PubMed:23885126).2 Publications

GO - Molecular functioni

GO - Biological processi

  • actin filament organization Source: FlyBase
  • chorion-containing eggshell formation Source: FlyBase
  • mitotic nuclear division Source: FlyBase
  • NLS-bearing protein import into nucleus Source: FlyBase
  • positive regulation of NFAT protein import into nucleus Source: FlyBase
  • protein import into nucleus Source: FlyBase
  • protein import into nucleus, docking Source: FlyBase
  • protein import into nucleus, translocation Source: GO_Central
  • regulation of cell shape Source: FlyBase
  • ribosomal protein import into nucleus Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-DME-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-DME-211227. Activation of DNA fragmentation factor.
R-DME-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit beta
Alternative name(s):
Karyopherin subunit beta
Protein ketel
Gene namesi
ORF Names:CG2637
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0262743. Fs(2)Ket.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • lipid particle Source: FlyBase
  • microtubule associated complex Source: FlyBase
  • nuclear envelope Source: FlyBase
  • nuclear membrane Source: GO_Central
  • nuclear periphery Source: GO_Central
  • nuclear pore Source: FlyBase
  • nucleoplasm Source: FlyBase
  • P granule Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207621 – 884Importin subunit betaAdd BLAST884

Proteomic databases

PaxDbiO18388.
PRIDEiO18388.

Expressioni

Tissue specificityi

Ubiquitously expressed in embryos.1 Publication

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

BgeeiFBgn0262743.
ExpressionAtlasiO18388. baseline.
GenevisibleiO18388. DM.

Interactioni

Subunit structurei

Forms a complex with an importin alpha subunit.

Protein-protein interaction databases

BioGridi61299. 10 interactors.
DIPiDIP-23049N.
IntActiO18388. 37 interactors.
MINTiMINT-1589981.
STRINGi7227.FBpp0294035.

Structurei

3D structure databases

ProteinModelPortaliO18388.
SMRiO18388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 37HEAT 1By similarityAdd BLAST30
Domaini27 – 107Importin N-terminalPROSITE-ProRule annotationAdd BLAST81
Repeati39 – 71HEAT 2By similarityAdd BLAST33
Repeati91 – 129HEAT 3By similarityAdd BLAST39
Repeati135 – 166HEAT 4By similarityAdd BLAST32
Repeati176 – 208HEAT 5By similarityAdd BLAST33
Repeati218 – 253HEAT 6By similarityAdd BLAST36
Repeati259 – 308HEAT 7By similarityAdd BLAST50
Repeati320 – 366HEAT 8By similarityAdd BLAST47
Repeati370 – 400HEAT 9By similarityAdd BLAST31
Repeati408 – 444HEAT 10By similarityAdd BLAST37
Repeati455 – 491HEAT 11By similarityAdd BLAST37
Repeati505 – 542HEAT 12By similarityAdd BLAST38
Repeati549 – 597HEAT 13By similarityAdd BLAST49
Repeati605 – 645HEAT 14By similarityAdd BLAST41
Repeati650 – 687HEAT 15By similarityAdd BLAST38
Repeati692 – 730HEAT 16By similarityAdd BLAST39
Repeati738 – 782HEAT 17By similarityAdd BLAST45
Repeati792 – 835HEAT 18By similarityAdd BLAST44
Repeati837 – 878HEAT 19By similarityAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni335 – 348IABBy similarityAdd BLAST14
Regioni340 – 425Ran-GTP bindingBy similarityAdd BLAST86

Sequence similaritiesi

Contains 19 HEAT repeats.By similarity
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1241. Eukaryota.
COG5215. LUCA.
GeneTreeiENSGT00550000074898.
HOGENOMiHOG000140938.
InParanoidiO18388.
KOiK14293.
OMAiMSNILPY.
OrthoDBiEOG091G01XQ.
PhylomeDBiO18388.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSDIAMQLI AILEKTVSPD KNELLSAKNF LEQAAASNLP EFLKALSEIL
60 70 80 90 100
VNTANSAVAR MAAGLQLKNH LTSKDEKVSQ QYQDRWHQFP SEIRELIKNN
110 120 130 140 150
ILAALGTENT RPSCAAQCVA YVAVIELPIN RWPMLIQTLV NKVVSEGSSE
160 170 180 190 200
MHRESALEAI GYICQDIRFG VMENQSNDVL TAIIHGMRKV EPSNHVRLAA
210 220 230 240 250
TTALHNSLEF TKSNFEKDME RNFIMEVVCE ATQCQDSQIC VAALQCLVKI
260 270 280 290 300
MTLYYQYMEP YMAQALFPIT LAAMKSDNDA VALQGIEFWS NVCDEEIDLA
310 320 330 340 350
IESQEATDQG RAPQRVSKHY ARGALQFLTP VLVEKLTKQD ECDDEDTWSP
360 370 380 390 400
AKAASVCLMV LATCCEDEIV PHVLPFIKEN IESPNWRFRD AAVMTFGSVL
410 420 430 440 450
NGLETNTLKP LVEQAMPTLI RLMYDSSVIV RDTIAWTFGR ICDIIPEAAI
460 470 480 490 500
NETYLQTLLE CFVKSLKSEP RVAANVCWAF IGLSDAAWEA AVTNDGETPE
510 520 530 540 550
TYALSPYFEY IITQLLETTD RSDGAQANLR CAAYQALMDM IKNSPLDCYL
560 570 580 590 600
VVQRTTLVIL ERLNQVMQME TQINNHSDRH QFNDLQSLLC ATLQSVLRKV
610 620 630 640 650
HEQDAPQISD AIMTALLTMF NSSAGKSGVV QEEAFLAVST LVELLGAQFA
660 670 680 690 700
KYMPAFKDFL VMGLKNFQEY QVCCAAVGLT GDIFRALKDL MVPYSNEIMT
710 720 730 740 750
VLINNLTEPT IHRTVKPQVL SAFGDIALSI GNHFLPYLSM VLDMLRVASN
760 770 780 790 800
LQTDANNFDM NEYINELRES ILEAYTGIIQ GLKGVDQTAH TDVMHMEPHL
810 820 830 840 850
MHIISFIKRI AQEGDVSDSM LASAAGFIGD LCTSFGPRLY PLLDDAIITQ
860 870 880
FLAEGKRSKA QRTKMLCTWA VKEIKKINTQ VITQ
Length:884
Mass (Da):98,696
Last modified:December 1, 2000 - v2
Checksum:iDE6DACB927B314EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002729 Genomic DNA. Translation: CAA05691.2.
AF222745 mRNA. Translation: AAF34680.1.
AE014134 Genomic DNA. Translation: AAF53918.1.
AY118657 mRNA. Translation: AAM50026.1.
RefSeqiNP_001246108.1. NM_001259179.2.
NP_001246109.1. NM_001259180.2.
NP_001246110.1. NM_001259181.2.
NP_001246111.1. NM_001259182.2.
NP_477496.1. NM_058148.5.
UniGeneiDm.3333.

Genome annotation databases

EnsemblMetazoaiFBtr0081392; FBpp0080922; FBgn0262743.
FBtr0305584; FBpp0294035; FBgn0262743.
FBtr0305585; FBpp0294036; FBgn0262743.
FBtr0305586; FBpp0294037; FBgn0262743.
FBtr0305587; FBpp0294038; FBgn0262743.
GeneIDi35336.
KEGGidme:Dmel_CG2637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002729 Genomic DNA. Translation: CAA05691.2.
AF222745 mRNA. Translation: AAF34680.1.
AE014134 Genomic DNA. Translation: AAF53918.1.
AY118657 mRNA. Translation: AAM50026.1.
RefSeqiNP_001246108.1. NM_001259179.2.
NP_001246109.1. NM_001259180.2.
NP_001246110.1. NM_001259181.2.
NP_001246111.1. NM_001259182.2.
NP_477496.1. NM_058148.5.
UniGeneiDm.3333.

3D structure databases

ProteinModelPortaliO18388.
SMRiO18388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61299. 10 interactors.
DIPiDIP-23049N.
IntActiO18388. 37 interactors.
MINTiMINT-1589981.
STRINGi7227.FBpp0294035.

Proteomic databases

PaxDbiO18388.
PRIDEiO18388.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081392; FBpp0080922; FBgn0262743.
FBtr0305584; FBpp0294035; FBgn0262743.
FBtr0305585; FBpp0294036; FBgn0262743.
FBtr0305586; FBpp0294037; FBgn0262743.
FBtr0305587; FBpp0294038; FBgn0262743.
GeneIDi35336.
KEGGidme:Dmel_CG2637.

Organism-specific databases

CTDi35336.
FlyBaseiFBgn0262743. Fs(2)Ket.

Phylogenomic databases

eggNOGiKOG1241. Eukaryota.
COG5215. LUCA.
GeneTreeiENSGT00550000074898.
HOGENOMiHOG000140938.
InParanoidiO18388.
KOiK14293.
OMAiMSNILPY.
OrthoDBiEOG091G01XQ.
PhylomeDBiO18388.

Enzyme and pathway databases

ReactomeiR-DME-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-DME-211227. Activation of DNA fragmentation factor.
R-DME-6798695. Neutrophil degranulation.

Miscellaneous databases

GenomeRNAii35336.
PROiO18388.

Gene expression databases

BgeeiFBgn0262743.
ExpressionAtlasiO18388. baseline.
GenevisibleiO18388. DM.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMB_DROME
AccessioniPrimary (citable) accession number: O18388
Secondary accession number(s): Q540Y0, Q9V3E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.