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Protein

Paired box protein Pax-6

Gene

ey

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in eye morphogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi430 – 489HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • RNA polymerase II regulatory region sequence-specific DNA binding Source: FlyBase
  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • adult walking behavior Source: FlyBase
  • brain development Source: FlyBase
  • brain morphogenesis Source: FlyBase
  • central complex development Source: FlyBase
  • compound eye development Source: FlyBase
  • compound eye morphogenesis Source: FlyBase
  • eye-antennal disc morphogenesis Source: FlyBase
  • glial cell migration Source: FlyBase
  • mushroom body development Source: FlyBase
  • neuron differentiation Source: FlyBase
  • photoreceptor cell fate specification Source: FlyBase
  • positive regulation of cell growth Source: FlyBase
  • positive regulation of cell proliferation Source: FlyBase
  • positive regulation of multicellular organism growth Source: FlyBase
  • positive regulation of transcription, DNA-templated Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • regulation of insulin-like growth factor receptor signaling pathway Source: FlyBase
  • regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiO18381.

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-6
Alternative name(s):
Protein eyeless
Gene namesi
Name:ey
Synonyms:pax6
ORF Names:CG1464
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 4

Organism-specific databases

FlyBaseiFBgn0005558. ey.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501931 – 857Paired box protein Pax-6Add BLAST857

Proteomic databases

PaxDbiO18381.
PRIDEiO18381.

Expressioni

Tissue specificityi

Expression is confined to the eye imaginal disks, parts of the brain, the ventral ganglion and the salivary glands.1 Publication

Gene expression databases

BgeeiFBgn0005558.
ExpressionAtlasiO18381. differential.
GenevisibleiO18381. DM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AntpP02833-14EBI-232318,EBI-15726199

Protein-protein interaction databases

BioGridi68643. 51 interactors.
DIPiDIP-46285N.
IntActiO18381. 14 interactors.
MINTiMINT-320712.
STRINGi7227.FBpp0099810.

Structurei

3D structure databases

ProteinModelPortaliO18381.
SMRiO18381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 182PairedPROSITE-ProRule annotationAdd BLAST127

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox, Paired box

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
InParanoidiO18381.
OrthoDBiEOG091G0S4E.
PhylomeDBiO18381.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
cd00131. PAX. 1 hit.
Gene3Di1.10.10.10. 2 hits.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR001523. Paired_dom.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
PRINTSiPR00027. PAIREDBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Larval (identifier: O18381-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRNLPCLGTA GGSGLGGIAG KPSPTMEAVE ASTASHRHST SSYFATTYYH
60 70 80 90 100
LTDDECHSGV NQLGGVFVGG RPLPDSTRQK IVELAHSGAR PCDISRILQV
110 120 130 140 150
SNGCVSKILG RYYETGSIRP RAIGGSKPRV ATAEVVSKIS QYKRECPSIF
160 170 180 190 200
AWEIRDRLLQ ENVCTNDNIP SVSSINRVLR NLAAQKEQQS TGSGSSSTSA
210 220 230 240 250
GNSISAKVSV SIGGNVSNVA SGSRGTLSSS TDLMQTATPL NSSESGGASN
260 270 280 290 300
SGEGSEQEAI YEKLRLLNTQ HAAGPGPLEP ARAAPLVGQS PNHLGTRSSH
310 320 330 340 350
PQLVHGNHQA LQQHQQQSWP PRHYSGSWYP TSLSEIPISS APNIASVTAY
360 370 380 390 400
ASGPSLAHSL SPPNDIESLA SIGHQRNCPV ATEDIHLKKE LDGHQSDETG
410 420 430 440 450
SGEGENSNGG ASNIGNTEDD QARLILKRKL QRNRTSFTND QIDSLEKEFE
460 470 480 490 500
RTHYPDVFAR ERLAGKIGLP EARIQVWFSN RRAKWRREEK LRNQRRTPNS
510 520 530 540 550
TGASATSSST SATASLTDSP NSLSACSSLL SGSAGGPSVS TINGLSSPST
560 570 580 590 600
LSTNVNAPTL GAGIDSSESP TPIPHIRPSC TSDNDNGRQS EDCRRVCSPC
610 620 630 640 650
PLGVGGHQNT HHIQSNGHAQ GHALVPAISP RLNFNSGSFG AMYSNMHHTA
660 670 680 690 700
LSMSDSYGAV TPIPSFNHSA VGPLAPPSPI PQQGDLTPSS LYPCHMTLRP
710 720 730 740 750
PPMAPAHHHI VPGDGGRPAG VGLGSGQSAN LGASCSGSGY EVLSAYALPP
760 770 780 790 800
PPMASSSAAD SSFSAASSAS ANVTPHHTIA QESCPSPCSS ASHFGVAHSS
810 820 830 840 850
GFSSDPISPA VSSYAHMSYN YASSANTMTP SSASGTSAHV APGKQQFFAS

CFYSPWV
Length:857
Mass (Da):89,492
Last modified:December 1, 2000 - v3
Checksum:i8EC3BA2F4C066269
GO
Isoform Embryonic (identifier: O18381-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MRNLPCLGTA...TYYHLTDDEC → MFTLQPTPTA...PSLEDMAHKG

Show »
Length:838
Mass (Da):87,650
Checksum:i8F7DEA4F14BC6393
GO
Isoform B (identifier: O18381-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.

Note: No experimental confirmation available.
Show »
Length:624
Mass (Da):65,106
Checksum:iCD39177789AA8EA7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249S → T in CAA56038 (PubMed:7914031).Curated1
Sequence conflicti367E → K in CAA56038 (PubMed:7914031).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti641A → T in strain: 253.27 and closs19. 1
Natural varianti697T → S in strain: 253.27 and closs19. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0023681 – 233Missing in isoform B. CuratedAdd BLAST233
Alternative sequenceiVSP_0023691 – 56MRNLP…TDDEC → MFTLQPTPTAIGTVVPPWSA GTLIERLPSLEDMAHKG in isoform Embryonic. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79492 mRNA. Translation: CAA56037.1.
X79493 mRNA. Translation: CAA56038.1.
AE014135 Genomic DNA. Translation: AAF59318.1.
AE014135 Genomic DNA. Translation: AAN06513.1.
AF433696 Genomic DNA. Translation: AAM17959.1.
AF433697 Genomic DNA. Translation: AAM17960.1.
AF433698 Genomic DNA. Translation: AAM17961.1.
AF433699 Genomic DNA. Translation: AAM17962.1.
AF433700 Genomic DNA. Translation: AAM17963.1.
AF433701 Genomic DNA. Translation: AAM17964.1.
AF433702 Genomic DNA. Translation: AAM17965.1.
AF433703 Genomic DNA. Translation: AAM17966.1.
AF433704 Genomic DNA. Translation: AAM17967.1.
AF433705 Genomic DNA. Translation: AAM17968.1.
PIRiI45557.
RefSeqiNP_524628.2. NM_079889.3. [O18381-2]
NP_726607.1. NM_166789.2. [O18381-3]
UniGeneiDm.6503.

Genome annotation databases

EnsemblMetazoaiFBtr0089235; FBpp0088299; FBgn0005558. [O18381-3]
FBtr0089236; FBpp0088300; FBgn0005558. [O18381-2]
GeneIDi43812.
KEGGidme:Dmel_CG1464.
UCSCiCG1464-RA. d. melanogaster. [O18381-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPAX6_DROME
AccessioniPrimary (citable) accession number: O18381
Secondary accession number(s): Q8ST91, Q8ST92, Q9V4F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 22, 2017
This is version 172 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families