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Protein
Submitted name:

CALX

Gene

Calx

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • calcium:sodium antiporter activity Source: FlyBase
  • calcium ion binding Source: FlyBase

GO - Biological processi

  • neuromuscular process controlling posture Source: FlyBase
  • phototransduction Source: FlyBase
  • response to endoplasmic reticulum stress Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-418359. Reduction of cytosolic Ca++ levels.
R-DME-425561. Sodium/Calcium exchangers.
R-DME-5578775. Ion homeostasis.

Protein family/group databases

TCDBi2.A.19.3.2. the ca(2+):cation antiporter (caca) family.

Names & Taxonomyi

Protein namesi
Submitted name:
CALXImported
Gene namesi
Name:CalxImported
ORF Names:CG5685Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0013995. Calx.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei124 – 14219HelicalSequence analysisAdd
BLAST
Transmembranei216 – 23722HelicalSequence analysisAdd
BLAST
Transmembranei249 – 27123HelicalSequence analysisAdd
BLAST
Transmembranei277 – 29822HelicalSequence analysisAdd
BLAST
Transmembranei781 – 80222HelicalSequence analysisAdd
BLAST
Transmembranei814 – 83320HelicalSequence analysisAdd
BLAST
Transmembranei853 – 87220HelicalSequence analysisAdd
BLAST
Transmembranei884 – 90421HelicalSequence analysisAdd
BLAST
Transmembranei924 – 94522HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 950928Sequence analysisPRO_5004157524Add
BLAST

Proteomic databases

PaxDbiO18367.
PRIDEiO18367.

Expressioni

Gene expression databases

BgeeiO18367.
ExpressionAtlasiO18367. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0301144.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini431 – 530100Calx-betaInterPro annotationAdd
BLAST
Domaini544 – 643100Calx-betaInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. [View classification]SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1306. Eukaryota.
ENOG410XPJP. LUCA.
OrthoDBiEOG7S4X56.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR004836. Na_Ca_Ex.
IPR032452. Na_Ca_Ex_C-exten.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
PF16494. Na_Ca_ex_C. 1 hit.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.

Sequencei

Sequence statusi: Complete.

O18367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLLLKSIFT CALFVIFVYA TAQSLLKVQE TEARQAYLNV TSSSSSNLSQ
60 70 80 90 100
DDGHFLSRRL RQVSHGEEGD EGAPSQMDDE LEQMTKVHGE APDAEDVREC
110 120 130 140 150
SEGLVLPLWM PQRNISVGDR LVRGFVYFVL LIYLFVGVSI IADRFMAAIE
160 170 180 190 200
AITSIERAVV VKGPNNTKQV MHVRIWNETV ANLTLMALGS SAPEILLSVI
210 220 230 240 250
EIYAKDFESG DLGPGTIVGS AAYNLFMIIA VCMIWIPAGE VRRIRHLRVF
260 270 280 290 300
FVTALFSVFA YVWLWLILSV FTPGVILVWE AIVTLLFFPL TVLWAYIAER
310 320 330 340 350
RLLVYKYMDK NYRVNKRGTV VAGEHDQVEM DAEKGPKQPM VTSARGNDAE
360 370 380 390 400
AFDEARREYI TLLTELRQKY PDADLEQLEM MAQEQVLARS GRSRAFYRIQ
410 420 430 440 450
ATRKMVGSGN LMRKIQERAH SDLTGVKAQL HAGDDEEADD PIRMYFEPGH
460 470 480 490 500
YTVMENCGEF EVRVVRRGDI STYASVEYET QDGTASAGTD FVGRKGLLSF
510 520 530 540 550
PPGVDEQRFR IEVIDDDVFE EDECFYIRLF NPSEGVKLAV PMIATVMILD
560 570 580 590 600
DDHAGIFAFT DSVFEITESV GRFELKVMRY SGARGTVIVP YWTENDTATE
610 620 630 640 650
SKDYEGARGE LVFENNESEK FIDLFILEES SYEKDVSFKV HIGEPRLAPD
660 670 680 690 700
DELAAKIKEV EKKPVQDLTE LDRILLLSKP RNGELTTAYV RIRESQEFKA
710 720 730 740 750
TVDKLVAKAN VSAVLGTSSW KEQFKDALTV IPADESEFDN DDEEEEVPSC
760 770 780 790 800
FSYVSHFVCL FWKVLFAFVP PTDICGGYVT FVVSIFVIGV ITAIIGDAAS
810 820 830 840 850
YFGCALNIKD SVTAILFVAL GTSIPDTFAS MIAAKHDEGA DNCIGNVTGS
860 870 880 890 900
NAVNVFLGIG LAWTIAAVYH SSHGMTFNVE PGTIGFAVAL FCGEALIAIM
910 920 930 940 950
LIMFRRWHKG IGAELGGPKV SKYISAAILV FLWVFYVVIC ILEAYDVIRV
Length:950
Mass (Da):106,047
Last modified:January 1, 1998 - v1
Checksum:i14A0DEF46360C727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009897 mRNA. Translation: AAB63464.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009897 mRNA. Translation: AAB63464.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0301144.

Protein family/group databases

TCDBi2.A.19.3.2. the ca(2+):cation antiporter (caca) family.

Proteomic databases

PaxDbiO18367.
PRIDEiO18367.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0013995. Calx.

Phylogenomic databases

eggNOGiKOG1306. Eukaryota.
ENOG410XPJP. LUCA.
OrthoDBiEOG7S4X56.

Enzyme and pathway databases

ReactomeiR-DME-418359. Reduction of cytosolic Ca++ levels.
R-DME-425561. Sodium/Calcium exchangers.
R-DME-5578775. Ion homeostasis.

Gene expression databases

BgeeiO18367.
ExpressionAtlasiO18367. differential.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR004836. Na_Ca_Ex.
IPR032452. Na_Ca_Ex_C-exten.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
PF16494. Na_Ca_ex_C. 1 hit.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Anomalous regulation of the Drosophila Na(+)-Ca2+ exchanger by Ca2+."
    Hryshko L.V., Matsuoka S., Nicoll D.A., Weiss J.N., Schwarz E.M., Benzer S., Philipson K.D.
    J. Gen. Physiol. 108:67-74(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Canton-SImported.
  2. Schwarz E.M., Benzer S.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Canton-SImported.

Entry informationi

Entry nameiO18367_DROME
AccessioniPrimary (citable) accession number: O18367
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.